Matter, energy and information network of a graphene-peptide-based fluorescent sensing system for molecular logic computing, detection and imaging of cancer stem cell marker CD133 in cells and tumor tissues

Abstract

A graphene-peptide-based fluorescent sensing system for molecular logic operations, sensing and imaging of CD133.

Recent advances of graphene–biomacromolecule nanocomposites in medical applications

“…Then, they constructed a fluorescence sensing system using the GO platform and CD133-specific recognition peptide. 97 The interaction of matter, energy and information in the system realized the molecular Boolean logic operation and sensitively detects CD133 (the detection limit is 7.91 nM). This system provided more opportunities for the development and design of molecular-level intelligence, and may facilitate the development of molecularlevel ''internet of things'' and artificial life.…”

Peptide-Based Sensing, Logic Computing, and Information Security on the Antimonene Platform

“…Synthetic combinatorial peptide libraries and random phage display technology can screen and obtain a considerable number of candidate affinity peptides, ,, which can specifically recognize a variety of target substances (metal ions such as Pb 2+ , , Cd 2+ , Hg 2+ ), biomarkers, , and nanomaterials (like perovskites, PbSe quantum dots) . For example, Pb 2+ -binding peptides, DHHTQQHD (DD8) and TNTLSNN ( K d = 3.3 × 10 –11 M), screened by phage display technology were used to develop biosensors for electrochemical and fluorescent detection of Pb 2+ . ,,− Other peptide-based sensing systems ,, were also used for sensing of DNA, biomarkers (matrix metalloproteinase MMP2, alkaline phosphatase), and gas-phase analytes .…”

“…Moreover, peptide-based logic computing recently started to attract the attention of a few researchers, but it is still in a very early stage compared with unconventional computing using other molecules. − For example, some peptide-based molecular recognition processes have also begun to be used to implement peptide logic computing (such as simple Boolean logic gates, , molecular keypad lock). Furthermore, the Boolean logic tree was used to connect and organize the matters and energy (like fluorescence) changes in the peptide-based system for developing complex logic circuits …”

“…58−62 For example, some peptide-based molecular recognition processes have also begun to be used to implement peptide logic computing (such as simple Boolean logic gates, 42,63 molecular keypad lock 47 ). Furthermore, the Boolean logic tree 36 was used to connect and organize the matters and energy (like fluorescence) changes in the peptide-based system for developing complex logic circuits. 64 Due to its extremely high data density (∼10 19 bits per cm 3 ) and long-term stability, DNA-based information storage 65 and security technology attracted the wide interest of researchers.…”

Microwave-Assisted Synthesis of Chromium Oxide Nanoparticles for Fluorescence Biosensing of Mercury Ions and Molecular Logic Computing

“…Due to the high sensitivity and visualization characteristics of fluorescence, exploring the fluorescence properties (fluorescence emission or fluorescence quenching , abilities) of nanomaterials (such as graphene or graphene quantum dots, gold nanoparticles or nanoclusters, and MoS 2 ) and combining biomolecules (such as DNA, peptides, and antibodies) will help to develop fluorescence biosensing and imaging approaches for disease diagnosis and environmental monitoring and to establish fluorescence molecular information technologies (molecular logic gates, molecular authentication, and cryptography). For example, some fluorescence nanoquenchers (graphene, WS 2 , MoS 2 , graphite carbon nitride (g-C 3 N 4 ) nanosheets, and carbon nanotubes) and biomolecular probes are widely used in biosensing, ,, medical diagnosis, and molecular logic computing (like simple logic gates) .…”