Measurement of levofloxacin in human plasma samples for a reliable and accessible drug monitoring

Aragón-Martínez, Othoniel Hugo; Isiordia-Espinoza, Mario Alberto; Galicia-Castillo, Oscar; Aranda‐Romo, Saray; Gómez, Alejandro Gómez; Romano‐Moreno, Silvia; Martinez-Morales, Flavio

doi:10.1016/j.clinbiochem.2016.09.011

Cited by 13 publications

(1 citation statement)

References 28 publications

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“…It has activity to both Gram‐positive and Gram negative bacteria and anaerobes. LEV containing pharmaceuticals are commonly used for the treatment of respiratory tract infections, skin infections and genitourinary tract infections . Quantitative determination of LEV has been studied by several analytical techniques such as spectrofluorimetry , nuclear magnetic resonance spectrometry , high‐performance liquid chromatography coupled with MS/MS , high performance liquid chromatography with photodiode array detector , UV spectrophotometric method and electrochemical technique .…”

Section: Introductionmentioning

confidence: 99%

Poly(Taurine‐Glutathione)/Carbon Nanotube Modified Glassy Carbon Electrode as a New Levofloxacin Sensor

Koçak

2019

Electroanalysis

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A new highly sensitive and selective electrochemical levofloxacin sensor based on co‐polymer‐carbon nanotube composite electrode was developed. Taurine and Glutathione were electrochemically co‐polymerized on multiwalled carbon nanotubes modified glassy carbon electrode (Poly(TAU‐GSH)/CNT/GCE) and used as a levofloxacin sensor in pH 6 phosphate buffer solution. The new composite electrode surfaces were characterized by scanning electron microscopy, atomic force microscopy and electrochemical impedance spectroscopy. Under the optimized conditions, two linear segments were obtained for increasing LEV concentrations between 20 nmol L−1‐1 μmol L−1 and 1.5 μmol L−1‐55 μmol L−1 LEV with a detection limit of 9 nmol L−1 using amperometry. Poly(TAU‐GSH)/CNT/GCE exhibited high sensitivity, selectivity with good stability. The new sensor was employed for real samples of LEV tablets and urine. Promising results were obtained with good accuracy which were also in accordance with LC‐MS/MS analysis.

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