Measurement of triclabendazole and its metabolites in liver flukes: method development and full validation

Mottier, L.; Moreno, Laura; Álvarez, Luis Ignacio Ortega; Virkel, G.; Lanusse, Carlos

doi:10.1016/j.jpba.2004.02.038

Cited by 22 publications

(23 citation statements)

References 25 publications

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“…Acetonitrile [11][12][13] and ethyl acetate [15] were found to be an effective solvent for extraction of TCB and its metabolites from biological samples. Acetonitrile was chosen as the extraction solvent because of its high extraction efficiency.…”

Section: Sample Preparationmentioning

confidence: 99%

“…Several methods have been published for the determination of TCB, TCB-SO, and TCB-SO 2 in milk [11,12] and in liver flukes [13]; TCB and TCB-SO 2 have been determined in animal liver as well [14]. Different techniques for analysis are used, such as HPLC-UV [11,13], HPLC-DAD [14], and UHPLC-MS/MS [12].…”

Section: Introductionmentioning

confidence: 99%

“…Different techniques for analysis are used, such as HPLC-UV [11,13], HPLC-DAD [14], and UHPLC-MS/MS [12]. Recently, Jedziniak et al [15] reported a screening method for the simultaneous determination of TCB, TCB-SO, TCB-SO 2 , and KETO, as well as other benzimidazoles in milk by HPLC-MS.…”

Section: Introductionmentioning

confidence: 99%

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Simultaneous determination of triclabendazole and its metabolites in bovine and goat tissues by liquid chromatography–tandem mass spectrometry

Cai

Zhang

Xue

et al. 2010

Journal of Chromatography B

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Section: Sample Preparationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Simultaneous determination of triclabendazole and its metabolites in bovine and goat tissues by liquid chromatography–tandem mass spectrometry

Cai

Zhang

Xue

et al. 2010

Journal of Chromatography B

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“…Other anthelmintics of some importance are triclabendazole (TBC), a benzimidazole effective against adult and immature Fasciola hepatica [50,51]. The active form of the drug the triclabendazole sulfoxide (TBCSO), blocks the movement of tegumental secretions, inhibits mitotic division in the reproductive cells and cause microtubule disruption.…”

Section: Drug Resistance and Anthelminticsmentioning

confidence: 99%

Role of ABC Transporters in Veterinary Drug Research and Parasite Resistance

Alvarez¹,

Merino²,

Molina³

et al. 2006

CDD

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A considerable body of research has been carried out in order to throw light on the pharmacological and toxicological impact of ATP-binding cassette (ABC) drug efflux transporters such as P-glycoprotein and Breast Cancer Resistance Protein (BCRP/ABCG2/MXR). Most studies focus on their role in rendering cancer cells resistant to anticancer drugs. Drug transporters are expressed in many tissues and they are strongly involved in the oral bioavailability, and the hepatobiliary, direct intestinal and renal excretion of many drugs. In veterinary therapy, some anti parasitic drugs and/or their metabolites, such as ivermectin, moxidectin, albendazole sulfoxide, which are widely used, have been shown to be actively transported by efflux pumps. This interaction plays an important role in drug disposition since its inhibition has been shown to increase the drug bioavailability in some domestic species. Moreover, some authors have reported that parasite resistance to anthelmintic drugs may be mediated by parasite P-glycoprotein efflux. In addition, the importance of milk residues for human nutrition has aroused increasing concern about the inadvertent transfer of drugs and other substances into mammary milk of domestic animals, potentially posing a health risk to consumers. Recently, the important role of BCRP in the secretion of its substrates in milk has been demonstrated.

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“…For the effective control of the residues of BZDs in foods, methods capable of detecting the complete range of marker residues should be applied. As to the determination of BZDs residues, liquid chromatography methods based on ultraviolet detection [7][8][9][10] and fluorometric detection [11] were frequently used. However, these detectors have low sensitivity and specificity.…”

Section: Introductionmentioning

confidence: 99%

Development of a liquid chromatography–tandem mass spectrometry with pressurized liquid extraction method for the determination of benzimidazole residues in edible tissues

Chen

Tao

Zhang

et al. 2011

Journal of Chromatography B

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Measurement of triclabendazole and its metabolites in liver flukes: method development and full validation

Cited by 22 publications

References 25 publications

Simultaneous determination of triclabendazole and its metabolites in bovine and goat tissues by liquid chromatography–tandem mass spectrometry

Simultaneous determination of triclabendazole and its metabolites in bovine and goat tissues by liquid chromatography–tandem mass spectrometry

Role of ABC Transporters in Veterinary Drug Research and Parasite Resistance

Development of a liquid chromatography–tandem mass spectrometry with pressurized liquid extraction method for the determination of benzimidazole residues in edible tissues

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