Mechanical stability of custom-made implants: Numerical study of anatomical device and low elastic Young's modulus alloy

Didier, Paul; Piotrowski, Boris; Fischer, Marie; Laheurte, Pascal

doi:10.1016/j.msec.2016.12.031

Cited by 15 publications

(9 citation statements)

References 41 publications

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“…To overcome these complications, the chemical and mechanical characteristics of these devices are being tuned accordingly. For example, several coatings have been exploited to reduce the biofilm formation [18][19][20] and increase the life expectancy of the implants [21][22][23], while tailorable mechanical responses can improve the formation of an optimal interaction with the physiological tissue [24][25][26], reducing the stress-shielding effect at the interface that is responsible for most of the failures of these devices. Among these perspectives, the surface composition and morphology are crucial parameters that influence the primary response of the body to an implant depending on the anatomical region [27].…”

Section: Introductionmentioning

confidence: 99%

Selective Laser Melting and Electron Beam Melting of Ti6Al4V for Orthopedic Applications: A Comparative Study on the Applied Building Direction

et al. 2020

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The 3D printing process offers several advantages to the medical industry by producing complex and bespoke devices that accurately reproduce customized patient geometries. Despite the recent developments that strongly enhanced the dominance of additive manufacturing (AM) techniques over conventional methods, processes need to be continually optimized and controlled to obtain implants that can fulfill all the requirements of the surgical procedure and the anatomical district of interest. The best outcomes of an implant derive from optimal compromise and balance between a good interaction with the surrounding tissue through cell attachment and reduced inflammatory response mainly caused by a weak interface with the native tissue or bacteria colonization of the implant surface. For these reasons, the chemical, morphological, and mechanical properties of a device need to be designed in order to assure the best performances considering the in vivo environment components. In particular, complex 3D geometries can be produced with high dimensional accuracy but inadequate surface properties due to the layer manufacturing process that always entails the use of post-processing techniques to improve the surface quality, increasing the lead times of the whole process despite the reduction of the supply chain. The goal of this work was to provide a comparison between Ti6Al4V samples fabricated by selective laser melting (SLM) and electron beam melting (EBM) with different building directions in relation to the building plate. The results highlighted the influence of the process technique on osteoblast attachment and mineralization compared with the building orientation that showed a limited effect in promoting a proper osseointegration over a long-term period.

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Section: Introductionmentioning

confidence: 99%

Selective Laser Melting and Electron Beam Melting of Ti6Al4V for Orthopedic Applications: A Comparative Study on the Applied Building Direction

et al. 2020

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“…Alginate scaffolds with HA exhibited excellent applications in bone tissue engineering and the delivery of drugs and cells 7. Hydroxyapatite enhanced the strength of the scaffold and bone formation through mimicking the native extracellular matrix of bone and promoted the adhesion of cells to the scaffold 8,9…”

Section: Introductionmentioning

confidence: 99%

<p>Icariin-loaded porous scaffolds for bone regeneration through the regulation of the coupling process of osteogenesis and osteoclastic activity</p>

Xie¹,

Sun²,

Yan³

et al. 2019

IJN

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Objective Icariin (IC) promotes osteogenic differentiation, and it may be a potential small molecule drug for local application in bone regeneration. Icariin-loaded hydroxyapatite/alginate (IC/HAA) porous composite scaffolds were designed in this study for the potential application of the sustainable release of icariin and subsequent bone regeneration. Methods An icariin-loaded hydroxyapatite/alginate porous composite scaffold was prepared and characterized by SEM and HPLC for morphology and release behavior, respectively. The mechanical properties, degradation in PBS and cytotoxicity on BMSCs were also evaluated by MTT assay, compression strength and calculation of weight remaining ratio, respectively. Rabbit BMSCs were cocultured with IC/HAA scaffolds, and ALP activity and Alizarin Red staining were performed to evaluate osteogenic differentiation induction. The mRNA and protein expression level of an osteogenic gene was detected by RT-PCR and Western blotting, respectively. In vivo animal models of critical bone defects in the radius of rabbit were used. Four and 12 weeks after the implantation of IC/HAA scaffolds in the bone defect, radiographic images of the radius were obtained and scored by using the Lane and Sandhu X-ray scoring system. Tissue samples were also evaluated using H&E and Masson staining, and an osteogenic gene and Wnt signaling pathway genes were detected. Results A hydroxyapatite/alginate (HAA) porous composite scaffold-loaded icariin was fabricated using a freeze-drying method. Our data indicated that the icariin was loaded in alginate scaffold without compromising the macro/microstructure or mechanical properties of the scaffold. Notably, the IC/HAA promoted the proliferation of rBMSCs without exerting cytotoxicity on rBMSCs. In vivo, rabbit radius bone defect experiments demonstrated that the IC/HAA scaffold exhibited better capacity for bone regeneration than HAA, and IC/HAA upregulated the relative expression levels of an osteogenic gene and the Wnt signaling pathway genes. Most notably, the IC/HAA scaffold also inhibited osteoclast activity in vivo. Conclusion Our data suggests a promising application for the use of HAA scaffolds to load icariin and promote bone regeneration in situ through mediation of the coupling processes of osteogenesis induction and osteoclast activity inhibition.

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“…The Young's modulus is a ratio of stress to strain (in the elastic zone) , measuring a material's resistance to deformation when a force is placed on it. A material of a low Young's modulus will deform easily, and vice versa [6]. We considered the safety factor and displacement of each material to determine the optimal material for our device.…”

Section: Materials Simulation In Autodesk Fusion 360mentioning

confidence: 99%

Soft Robotics in Body Assistance: An Intelligent Rehabilitation Device with Soft Continuum Actuation

et al. 2021

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In an effort to improve rehabilitation devices, the applications of soft robotics technologies to prosthetics and physical therapy was explored, particularly due to the benefits of the inherent properties of soft materials. A conceptual design for a soft robotics device prototype is proposed to assist with physical therapy for wrist tendonitis and arthritis, carpal tunnel syndrome, fractures and sprains, and compromised motor skills due to chronic stroke. The device assists in four motions that are commonly performed in wrist therapy: flexion, extension, and rotation (clockwise and counterclockwise) using soft pneumatic actuators to guide movements. The distinct directions were achieved by varying the lateral and radial strain limiting layers. The device uses embodied intelligence to make the device dynamically adaptable in real time, allowing for a customizable recovery process. A detailed model of the device was developed and the viability of the design was assessed using a suite of state-of-the-art simulation tools and limited hardware prototyping. Simulations were performed through integration of Rhinoceros 3D, Grasshopper 3D, Firefly, an Arduino microcontroller, biosensors, Python scripting, and visual parametric programming. Pressure and materials were simulated and tested in Simulia Abaqus and Autodesk Fusion 360. Several parametric variations were tried using simulations and the predictions revealed that rubber silicone at a pressure of 10 kiloPascals is the optimal choice.

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Mechanical stability of custom-made implants: Numerical study of anatomical device and low elastic Young's modulus alloy

Cited by 15 publications

References 41 publications

Selective Laser Melting and Electron Beam Melting of Ti6Al4V for Orthopedic Applications: A Comparative Study on the Applied Building Direction

Selective Laser Melting and Electron Beam Melting of Ti6Al4V for Orthopedic Applications: A Comparative Study on the Applied Building Direction

<p>Icariin-loaded porous scaffolds for bone regeneration through the regulation of the coupling process of osteogenesis and osteoclastic activity</p>

Soft Robotics in Body Assistance: An Intelligent Rehabilitation Device with Soft Continuum Actuation

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