Mechanism of piR-DQ590027/MIR17HG regulating the permeability of glioma conditioned normal BBB

Xue, L.; Ma, Jun; Liu, Yunhui; Shen, Shuyuan; Yu, Hai; Zheng, Jian; Liu, Xiaobai; Li, Libo; Chen, Jiajia; Zhao, Liye; Ruan, Xuelei; Xue, Yixue

doi:10.1186/s13046-018-0886-0

Cited by 47 publications

(32 citation statements)

References 47 publications

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“…Yuze Cao et al reported that lncRNA MIR17HG-mediated ceRNA network was identi ed as a potential prognostic biomarker for glioblastoma [22]. Moreover, Xue Leng et al observed that MIR17HG was highly expressed in glioma and participated in piR-DQ590027/ lncRNA MIR17HG/miR-153(miR-377)/FOXR2 pathway which involved in regulating the permeability of glioma-conditioned normal bloodbrain barrier [23]. These results suggested that lncRNA MIR17HG could be of pathogenic importance in the development and prognosis of glioma.…”

Section: Discussionmentioning

confidence: 99%

Genetic variants in MIR17HG affect the susceptibility and prognosis of glioma in a Chinese Han population

Feng

Ouyang

et al. 2020

Preprint

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Background: lncRNA MIR17HG was upregulated in glioma, and participated in promoting proliferation, migration and invasion of glioma. However, the role of MIR17HG polymorphisms in the occurrence and prognosis of glioma is still unclear.Methods: In the study, 592 glioma patients and 502 control subjects were recruited. Agena MassARRAY platform was used to detect the genotype of MIR17HG polymorphisms. Logistic regression analysis was used to evaluate the relationship between MIR17HG single nucleotide polymorphisms (SNPs) and glioma risk by odds ratio (OR) and 95% confidence intervals (CIs). Kaplan–Meier curves, Cox hazards models were performed for assessing the role of these SNPs in glioma prognosis by hazard ratios (HR) and 95% CIs.Results: We found that rs7318578 (OR = 2.25, p = 3.18´10-5) was significantly associated with glioma susceptibility in the overall participants. In the subgroup with age < 40 years, rs17735387 (OR = 1.53, p = 9.05´10-3) and rs7336610 (OR = 1.35, p = 0.016) were related to the higher glioma susceptibility. More importantly, rs17735387 (HR = 0.82, log-rank p = 0.026) were associated with the longer survival of glioma patients. The GA genotype of rs17735387 had a better overall survival (HR = 0.75, log-rank p = 0.013) and progression free survival (HR = 0.73, log-rank p = 0.032) in patients with Ⅰ-Ⅱ glioma. We also found that rs72640334 was related to the poor prognosis (HR = 1.49, Log-rank p = 0.035) in female patients. In the subgroup of patients with age ³ 40 years, rs17735387 was associated with a better prognosis (HR = 0.036, Log-rank p = 0.002).Conclusion: Our study firstly reported that MIR17HG rs7318578 was a risk factor for glioma susceptibility and rs17735387 was associated with the longer survival of glioma among Chinese Han population, which might help to enhance the understanding of MIR17HG gene in gliomagenesis.

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Section: Discussionmentioning

confidence: 99%

Genetic variants in MIR17HG affect the susceptibility and prognosis of glioma in a Chinese Han population

Feng

Ouyang

et al. 2020

Preprint

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“…Yuze Cao et al reported that lncRNA MIR17HG-mediated ceRNA network was identified as a potential prognostic biomarker for glioblastoma [22]. Moreover, Xue Leng et al observed that MIR17HG was highly expressed in glioma and participated in piR-DQ590027/ lncRNA MIR17HG/ miR-153(miR-377)/FOXR2 pathway which involved in regulating the permeability of glioma-conditioned normal blood-brain barrier [23]. These results suggested that lncRNA MIR17HG could be of pathogenic importance in the development and prognosis of glioma.…”

Section: Discussionmentioning

confidence: 99%

Genetic variants in MIR17HG affect the susceptibility and prognosis of glioma in a Chinese Han population

Feng

Ouyang

et al. 2020

BMC Cancer

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Background lncRNA MIR17HG was upregulated in glioma, and participated in promoting proliferation, migration and invasion of glioma. However, the role of MIR17HG polymorphisms in the occurrence and prognosis of glioma is still unclear. Methods In the study, 592 glioma patients and 502 control subjects were recruited. Agena MassARRAY platform was used to detect the genotype of MIR17HG polymorphisms. Logistic regression analysis was used to evaluate the relationship between MIR17HG single nucleotide polymorphisms (SNPs) and glioma risk by odds ratio (OR) and 95% confidence intervals (CIs). Kaplan–Meier curves, Cox hazards models were performed for assessing the role of these SNPs in glioma prognosis by hazard ratios (HR) and 95% CIs. Results We found that rs7318578 (OR = 2.25, p = 3.18 × 10− 5) was significantly associated with glioma susceptibility in the overall participants. In the subgroup with age < 40 years, rs17735387 (OR = 1.53, p = 9.05 × 10− 3) and rs7336610 (OR = 1.35, p = 0.016) were related to the higher glioma susceptibility. More importantly, rs17735387 (HR = 0.82, log-rank p = 0.026) were associated with the longer survival of glioma patients. The GA genotype of rs17735387 had a better overall survival (HR = 0.75, log-rank p = 0.013) and progression free survival (HR = 0.73, log-rank p = 0.032) in patients with I-II glioma. We also found that rs72640334 was related to the poor prognosis (HR = 1.49, Log-rank p = 0.035) in female patients. In the subgroup of patients with age ≥ 40 years, rs17735387 was associated with a better prognosis (HR = 0.036, Log-rank p = 0.002). Conclusion Our study firstly reported that MIR17HG rs7318578 was a risk factor for glioma susceptibility and rs17735387 was associated with the longer survival of glioma among Chinese Han population, which might help to enhance the understanding of MIR17HG gene in gliomagenesis. In subsequent studies, we will continue to collect samples and follow up to further validate our findings and further explore the function of these MIR17HG SNPs in glioma in a larger sample size.

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“…Das et al found that transient overexpression of piR-39980 can attenuate the proliferation and induce apoptosis of HT1080 fibrosarcoma cells, and has a strong antitumor effect [23]. Glioblastoma has also been linked to piRNA, Leng et al found that overexpression of piR-DQ590027 increased the permeability of the blood-brain barrier under glioma conditions and promoted the transport of anti-glioma drugs to glioma tissue [24].…”

Section: Introductionmentioning

confidence: 99%

SPRDA: a matrix completion approach based on the structural perturbation to infer disease-associated Piwi-Interacting RNAs

Zheng

You

wang

et al. 2020

Preprint

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AbstractEmerging evidence suggests that PIWI-interacting RNAs (piRNAs) are one of the most influential small non-coding RNAs (ncRNAs) that regulate RNA silencing. piRNA and PIWI proteins have been confirmed for disease diagnosis and treatment as novel biomarkers due to its abnormal expression in various cancers. However, the current research is not strong enough to further clarify the functions of piRNA in cancer and its underlying mechanism. Therefore, how to provide large-scale and serious piRNA candidates for biological research has grown up to be a pressing issue. The main motivation of this work is tantamount to fill the gap in research on large-scale prediction of disease-related piRNAs. In this study, a novel computational model based on the structural perturbation method is proposed, called SPRDA. In detail, the duplex network is constructed based on the piRNA similarity network and disease similarity network extracted from piRNA sequence information, Gaussian interaction profile kernel similarity information and gene-disease association information. The structural perturbation method is then used to predict the potential associations on the duplex network, which is more predictive than other network structures in terms of structural consistency. In the five-fold cross-validation, SPRDA shows high performance on the benchmark dataset piRDisease, with an AUC of 0.9529. Furthermore, the predictive performance of SPRDA for 10 diseases shows the robustness of the proposed method. Overall, the proposed approach can provide unique insights into the pathogenesis of the disease and will advance the field of oncology diagnosis and treatment.

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Mechanism of piR-DQ590027/MIR17HG regulating the permeability of glioma conditioned normal BBB

Cited by 47 publications

References 47 publications

Genetic variants in MIR17HG affect the susceptibility and prognosis of glioma in a Chinese Han population

Genetic variants in MIR17HG affect the susceptibility and prognosis of glioma in a Chinese Han population

Genetic variants in MIR17HG affect the susceptibility and prognosis of glioma in a Chinese Han population

SPRDA: a matrix completion approach based on the structural perturbation to infer disease-associated Piwi-Interacting RNAs

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