Mediatory effect of circulating vaspin on resting metabolic rate in obese individuals

Moradi, Sajjad; Abdurahman, Ahmed Abdulahi; Keshavarz, Seyed Ali; Hossein–Nezhad, Arash

doi:10.1007/s00394-015-0948-4

Cited by 36 publications

(24 citation statements)

References 51 publications

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“…Youn et al also found that patients with obesity or abnormal insulin sensitivity had elevated serum vaspin levels [19]. Additionally, the serum vaspin concentration in obese patients was higher than that in nonobese patients in the same research [17]. Salama et al (2015) found that vaspin levels are increased in obese children and identified correlations between vaspin concentration and WHR; however, they concluded that vaspin was a less sensitive indicator of abdominal obesity and insulin resistance in obese children compared with visfatin [20].…”

Section: Discussionmentioning

confidence: 95%

“…Also, changes in visceral fat are associated with concomitant changes in glucose tolerance and insulin resistance [16]. It was reported that central adiposity bestows enhanced risk of metabolic complications as compared with peripheral adiposity [17]. Previous study has found that vaspin may improve the metabolism of glucose and decrease glucose concentration [18].…”

Section: Discussionmentioning

confidence: 99%

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Serum Vaspin Concentration in Elderly Type 2 Diabetes Mellitus Patients with Differing Body Mass Index: A Cross-Sectional Study

Yang

Tian

et al. 2017

BioMed Research International

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Aims. This study was to evaluate the association of serum vaspin concentrations with body mass index (BMI) among elderly patients (>60 years old). Methods. A total of 227 elderly individuals included 76 healthy with normal glucose tolerance, which divided into normal weight control (BMI < 25, n = 38) and overweight or obese control (BMI ≥ 25, n = 38) subgroups, and 150 T2DM patients, which divided into normal weight diabetes (BMI < 25, n = 55), overweight diabetes (30 > BMI ≥ 25, n = 52), and obese diabetes (BMI ≥ 30, n = 43) subgroups. Relevant parameters were matched for age and gender ratio. Serum vaspin concentrations were measured by enzyme-linked immunosorbent assay. Results. Serum vaspin concentration was significantly higher in the T2DM than the healthy (451.9 ± 32.6 versus 284.2 ± 21.7, P < 0.01). In the diabetic patients, the vaspin concentration was significantly higher in the obese group than the normal weight group (498.2 ± 17.1 versus 382.1 ± 21.3, P < 0.05). In addition, the concentration of vaspin in normal weight T2DM was higher than in healthy control group with normal weight (382.1 ± 21.3 versus 192.5 ± 45.2, P < 0.05). Multiple regression analysis revealed that BMI was independent factors influencing the serum vaspin concentration in all participants. Conclusion. Vaspin may play an important compensatory role in obesity and insulin resistance in elderly people. The clinical trial registration number is ChiCTR-OPC-14005698.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Serum Vaspin Concentration in Elderly Type 2 Diabetes Mellitus Patients with Differing Body Mass Index: A Cross-Sectional Study

Yang

Tian

et al. 2017

BioMed Research International

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“…Complete body composition analysis was explained previously [24]. Body composition analyzer BC-418MA-Tanita (United Kingdom) was used to calculate the participant’s body composition [25] including weight, fat mass, fat-free mass, body fat percentage, muscle mass, visceral fat mass, abdominal fat mass. Total body water basis of data were obtained by dual energy X-ray absorptiometry using Bioelectrical Impedance Analysis.…”

Section: Methodsmentioning

confidence: 99%

Vitamin D Status and Resting Metabolic Rate May Modify through Expression of Vitamin D Receptor and Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene in Overweight and Obese Adults

Sajjadi¹,

Mirzaei

Khorraminezhad

et al. 2017

Ann Nutr Metab

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Background: Resting metabolic rate (RMR) used to prognosticate and measure the amount of energy required. Vitamin D is known as a new predictor of RMR. The aim of this study is to investigate the relationship between vitamin D effects on RMR in connection with the vitamin D receptor (VDR) and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) gene expression. Methods: We enrolled 298 overweight and obese adults in this cross-sectional study. Body mass index (BMI), fat mass, fat-free mass, insulin level, visceral fat, and vitamin D status were assessed. RMR was measured by means of indirect calorimetry. The real-time polymerase chain reaction using specific primer pairs for VDR and PGC-1α was performed. Results: There were significant differences in terms of fat free mass, fat percentage, insulin levels, RMR/kg body weight, and RMR/BMI, VDR, and PGC-1α among participants were categorized based on the vitamin D status. But after using general linear model for adjusting, all significant results missed their effectiveness except RMR/kg body weight and VDR. Linear regression analysis used to show the mediatory role of VDR and PGC-1α on the RMR/kg body weight and vitamin D status relationship. Our results showed that VDR had a mediatory effect on the relationship between RMR/kg body weight and vitamin D status (β = 0.38, 95% CI –0.48 to 1.60; β = –1.24, 95% CI –5.36 to 1.70). However, PGC-1α did not affect the relationship between RMR/kg body weight and vitamin D status (β = 0.50, 95% CI = –0.02 to 3.42; β = 0.59, 95% CI 0.14–3.90). Conclusion: Our study showed the mediatory effect of VDR gene expression in the association of 25(OH)₂D plasma levels and resting metabolic rate among obese individuals.

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“…Vitamin D supplementation had no significant effect on vaspin levels, however, a cross sectional study indicated that serum vaspin and vitamin D have negative correlation (Zorlu et al, ). We could not find any clinical trials in the literature evaluating the effect of vitamin D treatment on vaspin concentrations (Moradi, Mirzaei, Abdurahman, Keshavarz, & Hossein‐nezhad, ).…”

Section: Discussionmentioning

confidence: 98%

The effects of supplementation with vitamin D on inflammatory biomarkers, omentin, and vaspin in women with type 2 diabetes: A randomized double‐blind placebo‐controlled clinical trial

Fazelian

Paknahad

Khajehali³

et al. 2018

J Food Biochem

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Type 2 diabetes (T2DM) is a global problem that increases the risk of inflammation and hormonal dysfunction. The purpose of this study was to determine the effect of vitamin D on inflammatory biomarkers, omentin, and vaspin in diabetic women with anxiety. In this study, 51 women with T2DM were allocated to receive one oral pearl of 50,000 IU vitamin D3 (26) or a placebo (25) fortnightly for 16 weeks. Anthropometric indices, dietary intake, high sensitivity C‐reactive protein (hs‐CRP), Interleukin 10 (IL‐10), vaspin, and omentin were measured at the baseline and after 16‐weeks supplementation. Serum hs‐ CRP was reduced (p = 0.01) and IL‐10 concentrations was increased (p = 0.04) in intervention group. Vitamin D marginally increased serum levels of omentin (p = 0.06), however, vaspin did not change post‐intervention. According to subgroup analysis, omentin levels increased significantly in participants with lower baseline serum vitamin D (p = 0.008). Vitamin D can improve anti‐inflammatory biomarkers in diabetic patients. Practical applications Diabetes is prevalent in the world. Inflammation in diabetic patients causes other chronic diseases such as cardio vascular disease. Adipose tissue contributes to the regulation of metabolism and insulin sensitivity. Two hormones secreted from adipose tissue that play an important role in insulin function and anti‐inflammatory activity. Vitamin D, can improve insulin sensitivity and inflammation via effects on the adipocytokines secretion. For the first time, a trial study conducted to determine the effect of vitamin D on inflammation and the serum levels of omentin and vaspin.

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Mediatory effect of circulating vaspin on resting metabolic rate in obese individuals

Abstract: Circulating vaspin level is higher in women than in men in obese individuals. Moreover, it was found that vaspin had mediator effect between visceral fat and fat mass associations with RMR in obese participants.

Cited by 36 publications

References 51 publications

Serum Vaspin Concentration in Elderly Type 2 Diabetes Mellitus Patients with Differing Body Mass Index: A Cross-Sectional Study

Serum Vaspin Concentration in Elderly Type 2 Diabetes Mellitus Patients with Differing Body Mass Index: A Cross-Sectional Study

Vitamin D Status and Resting Metabolic Rate May Modify through Expression of Vitamin D Receptor and Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene in Overweight and Obese Adults

The effects of supplementation with vitamin D on inflammatory biomarkers, omentin, and vaspin in women with type 2 diabetes: A randomized double‐blind placebo‐controlled clinical trial

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