Medical versus surgical termination of the first trimester missed miscarriage

Shuaib, Alia A.; Al-Harazi, Abdelrahman H.

doi:10.1016/j.ajme.2012.08.004

Cited by 21 publications

(14 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For instance, the patients' selection and exclusion criteria in our study were basically different from Zikopoulos et al 15 study, because Zikopoulos excluded women with prior elective abortion and parity more than three, but we only excluded patients with prior infected abortion. 15 Only one study by Shuaib et al 24 in 2013 administered a similar dose of misoprostol (1600µg/day) to our study and showed lower successful rate than our experience. The study compared the success rate and complications of medical abortion by 400µg misoprostol for induction and 200µg every 4 hours with the surgical abortion and showed 21% success rate after 12 hours (1000µg) and 57% success rate after 24 hours (1600µg) of treatment 24 that was lower than our results in group treated with 1600µg daily with 60% success rate.…”

Section: Discussioncontrasting

confidence: 46%

“…15 Only one study by Shuaib et al 24 in 2013 administered a similar dose of misoprostol (1600µg/day) to our study and showed lower successful rate than our experience. The study compared the success rate and complications of medical abortion by 400µg misoprostol for induction and 200µg every 4 hours with the surgical abortion and showed 21% success rate after 12 hours (1000µg) and 57% success rate after 24 hours (1600µg) of treatment 24 that was lower than our results in group treated with 1600µg daily with 60% success rate.…”

Section: Discussioncontrasting

confidence: 46%

See 1 more Smart Citation

Comparison of the effect between two doses of vaginal misoprostol in the termination of first-trimester pregnancy: a double-blinded randomized trial

Farzaneh¹,

Khosravi²,

Hosseini³

et al. 2018

OGIJ

View full text Add to dashboard Cite

Comparison of the effect between two doses of vaginal misoprostol in the termination of firsttrimester pregnancy: a double-blinded randomized trial Submit Manuscript | http://medcraveonline.com IntroductionThe management of pregnancy termination by induced abortion is a prevalent obstetrics and gynecologic operation, however, it is invasive and in some cases risky procedure.1,2 Therefore, some specialists have presented medical abortion as an alternative for surgical abortion especially in mothers with early gestational age less than 7 weeks.3 Mifepristone was the first agent used for medical termination of pregnancy 4 and some years later methotrexate was approved for medical abortion.5 Prostaglandin agents are the most common drugs, to achieve the medical termination in women in the first and second trimester of pregnancy. 4 Misoprostol is a synthetic analog of prostaglandin E1 that firstly was approved by the Food and Drug Administration (FDA) for peptic ulcer 4 and later it has been administered in patients with unwilling pregnancy to induce abortion. 5,6 Bugalho et al. 7 administered vaginal misoprostol for medical abortion and demonstrated that it was effective agent to terminate the pregnancy and the successful rate was about 80%, 7 furthermore, these results repeated in some other trials used misoprostol and revealed it is high efficient agent with low serious side effects in women under medical abortion. 8−12To increase the efficacy of misoprostol, it has been used in combination with other agents such as methotrexate and mifepristone for the termination of pregnancy in the first trimester and reported a highly efficacy ranged from 83-97%.13,14 On the other hand, recent experiences proved that women are more satisfied with medical abortion using misoprostol. In this regard, a study by Zikopoulos revealed that 91.3% of the women are satisfied with medical termination and they were very keen to choose it again and recommended it to other women.15 Some other practices confirmed more efficacies with higher doses of misoprostol.16−20 Therefore, in this randomized double-blinded clinical trial we compared the efficacy of two doses of vaginal misoprostol for elective termination of pregnancies in women with gestational age less than 96 days. Materials and methodsThe study was prospectively conducted at Imam Hussein University Hospital between 2013 and 2014. The research has been approved by the ethic committee of Shahid Beheshti University of Medical Sciences, Tehran, Iran (registration number sbmu. rec.1393.553). Our plan is comparison of the effect between two doses of vaginal misoprostol in the termination of first-trimester pregnancy. The criteria for enrollment were singleton pregnancy, indication for pregnancy termination due to either fetal or maternal causes or gestational age ≤96 days (e.g, missed abortion, blighted ovum, and maternal medical problem). The exclusion criteria were Review Article AbstractBackground and aim: a higher dose of misoprostol may increase its efficacy on the termination of pr...

show abstract

Section: Discussioncontrasting

confidence: 46%

Section: Discussioncontrasting

confidence: 46%

Comparison of the effect between two doses of vaginal misoprostol in the termination of first-trimester pregnancy: a double-blinded randomized trial

Farzaneh¹,

Khosravi²,

Hosseini³

et al. 2018

OGIJ

View full text Add to dashboard Cite

show abstract

“…В двух исследованиях, проведенных относительно недавно [21,22], получены кардинально противоположные результаты. A. Shuaib, A. Alharazi [21] По результатам многоцентрового исследования, проведенного в университетах Колумбии, Майами, Пенсильвании и Питсбурга [24], кровотечение после медикаментозного прерывания беременности обильнее и длительнее, но оно не требует хирургического вмешательства. По результатам представленного исследования статистически значимых различий в объеме визуально теряемой крови не выявлено (p>0,05).…”

Section: Discussionunclassified

Efficiency of various methods for termination of nondeveloping early pregnancy: A randomized clinical trial

Karmyshev¹,

Ryskeldieva²,

Sorokin³

2017

Ross. vestn. akush.-ginekol.

View full text Add to dashboard Cite

“…Nach 14 Tagen lag die Erfolgsrate bereits bei 62 %, nach 21 Tagen bei 76 % und nach vier Wochen bei 84 %. Insgesamt erlebten demnach 71 von 85 Frauen einen spontanen Abort.FazitSowohl die Kürettage als auch die Vaku umaspiration haben eine hohe Erfolgsra te, die in Studien meist zwischen 95 und 100 % liegt[24,8,15].…”

unclassified

Fehlgeburten: Abwarten oder eingreifen?

Wurzer¹

2016

Hebamme

View full text Add to dashboard Cite

?ber 50 Prozent aller biochemisch nachweisbaren Schwangerschaften f?hren ? oft unbemerkt ? zum spontanen Abort. Eine Fehlgeburt erleben Betroffene als Ausnahmezustand mit qu?lenden Fragen: ?Warum wir?? ?Warum unser Kind?? Und: ?Was nun?? Hebammen und ?rzte k?nnen Eltern helfen, die Situation anzunehmen und eine informierte Entscheidung f?r das weitere Vorgehen zu treffen.

show abstract

Medical versus surgical termination of the first trimester missed miscarriage

Cited by 21 publications

References 16 publications

Comparison of the effect between two doses of vaginal misoprostol in the termination of first-trimester pregnancy: a double-blinded randomized trial

Comparison of the effect between two doses of vaginal misoprostol in the termination of first-trimester pregnancy: a double-blinded randomized trial

Efficiency of various methods for termination of nondeveloping early pregnancy: A randomized clinical trial

Fehlgeburten: Abwarten oder eingreifen?

Contact Info

Product

Resources

About