Melanoma, Growth Factors, Acanthosis Nigricans, the Sign of Leser-Trélat, and Multiple Acrochordons

Ellis, Darrel L.; Kafka, Shelly; Chow, Jim C.; Nanney, Lillian B.; Inman, Wendelyn H.; McCadden, Michael E.; King, Lloyd E.

doi:10.1056/nejm198712173172506

Cited by 213 publications

(55 citation statements)

References 16 publications

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“…TGF-alpha has been found in retina, neural tissues and tumors [71–73]. Abnormal interactions between TGF-alpha and the transcription factor IRF6 (interferon regulatory factor-6) are associated with tooth agenesis and cleft lip-palate development [74].…”

Section: Discussionmentioning

confidence: 99%

Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: Implications for population susceptibility to diseases

Kenney

Chwa

Atilano

et al. 2014

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

145

119

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The geographic origins of populations can be identified by their maternally inherited mitochondrial DNA (mtDNA) haplogroups. This study compared human cybrids (cytoplasmic hybrids), which are cell lines with identical nuclei but mitochondria from different individuals with mtDNA from either the H haplogroup or L haplogroup backgrounds. The most common European haplogroup is H while individuals of maternal African origin are of the L haplogroup. Despite lower mtDNA copy numbers, L cybrids had higher expression levels for nine mtDNA-encoded respiratory complex genes, decreased ATP turnover rates and lower levels of ROS production, parameters which are consistent with more efficient oxidative phosphorylation. Surprisingly, GeneChip arrays showed that the L and H cybrids had major differences in expression of genes of the canonical complement system (5 genes), dermatan/chondroitin sulfate biosynthesis (5 genes) and CCR3 signaling (9 genes). Quantitative nuclear gene expression studies confirmed that L cybrids had (a) lower expression levels of complement pathway and innate immunity genes and (b) increased levels of inflammation-related signaling genes, which are critical in human diseases. Our data support the hypothesis that mtDNA haplogroups representing populations from different geographic origins may play a role in differential susceptibilities to diseases.

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Section: Discussionmentioning

confidence: 99%

Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: Implications for population susceptibility to diseases

Kenney

Chwa

Atilano

et al. 2014

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

145

119

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“…Here, we describe a case of pleural effusion presenting as an first manifestation of metastatic malignant melanoma in association with Leser-Trélat signal. [4][5][6] A 71-year-old non-smoking woman, with a history of diabetes mellitus type 2, arterial hypertension and ischaemic cardiomyopathy with moderate left ventricular dysfunction and coronary disease.…”

Section: Descriptionmentioning

confidence: 99%

Leser-Trélat sign in metastatic melanoma to pleura

2019

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“…Dieses Polypeptid ist strukturell eng mit dem Epidermal Growth Factor (EGF) verwandt, wobei sowohl TGF-α als auch EGF an den EGF-Rezeptor binden. Eine vermehrte Expression des EGF-Rezeptors und von TGF-α ist in Magentumorgewebe nachgewiesen worden [9,17], die Hochregulation des EGF-Rezeptors auch in den papillomatö-sen kutanen Hyperplasien [7,8,9]. Für verschiedene Tumoren wurde zudem der Nachweis erhöhter Urin-oder Serum-TGF-α-Spiegel geführt [7,9].…”

Section: Klinisch-chemische Untersuchungenunclassified

“…Eine vermehrte Expression des EGF-Rezeptors und von TGF-α ist in Magentumorgewebe nachgewiesen worden [9,17], die Hochregulation des EGF-Rezeptors auch in den papillomatö-sen kutanen Hyperplasien [7,8,9]. Für verschiedene Tumoren wurde zudem der Nachweis erhöhter Urin-oder Serum-TGF-α-Spiegel geführt [7,9]. Bei Abfall der Serumspiegel von TGF-α unter Tumorreduktion [9] Acanthosis nigricans, papillomatosis mucosae and tripe palms in a patient with metastasized gastric carcinoma 5 History and clinical findings: A 48-year-old obese man presented with thickening, coarseness and hyperpigmentation of the skin, especially of the intertriginous areas, papillomatous to verrucous lesions of the lips and buccal oral mucosa, and hyperkeratosis of the palms ("tripe palms") and soles.…”

Section: Klinisch-chemische Untersuchungenunclassified

Acanthosis nigricans, Papillomatosis mucosae und „tripe palms” bei einem Patienten mit metastasiertem Magenkarzinom

Kleikamp

Böhm²,

Frosch³

et al. 2006

Dtsch med Wochenschr

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Melanoma, Growth Factors, Acanthosis Nigricans, the Sign of Leser-Trélat, and Multiple Acrochordons

Cited by 213 publications

References 16 publications

Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: Implications for population susceptibility to diseases

Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: Implications for population susceptibility to diseases

Leser-Trélat sign in metastatic melanoma to pleura

Acanthosis nigricans, Papillomatosis mucosae und „tripe palms” bei einem Patienten mit metastasiertem Magenkarzinom

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