2022
DOI: 10.3389/fmicb.2022.1050869
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Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review

Abstract: α-Glucosidase and α-amylase are the two main glycosidases that participate in the metabolism of carbohydrates. Inhibitors of these two enzymes are considered an important medical treatment for carbohydrate uptake disorders, such as diabetes and obesity. Microbes are an important source of constituents that have the potential to inhibit glycosidases and can be used as sources of new drugs and dietary supplements. For example, the α-glucosidase inhibitor acarbose, isolated from Actinoplanes sp., has played an im… Show more

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Cited by 8 publications
(1 citation statement)
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“…3 Plants and microorganisms are rich sources of α-glucosidase and αamylase inhibitors. 3,4 One of the inhibitor agents commonly used in diabetes management is acarbose. However, acarbose has side effects, such as diarrhea, abdominal bloating, and borborygmus.…”
Section: Introductionmentioning
confidence: 99%
“…3 Plants and microorganisms are rich sources of α-glucosidase and αamylase inhibitors. 3,4 One of the inhibitor agents commonly used in diabetes management is acarbose. However, acarbose has side effects, such as diarrhea, abdominal bloating, and borborygmus.…”
Section: Introductionmentioning
confidence: 99%