Metastasis of Hepatocellular Carcinoma into the Mandible with Radiographic Findings Mimicking a Radicular Cyst: A Case Report

Fujihara, Hisako; Chikazu, Daichi; Saijo, Hideto; Suenaga, Hideyuki; Mori, Yoshiyuki; Iino, Mitsuyoshi; Hamada, Y.; Takato, Tsuyoshi

doi:10.1016/j.joen.2010.05.009

Cited by 15 publications

(16 citation statements)

References 27 publications

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“…5 Lesions with an appearance mimicking a radicular cyst have also been reported. 6 In our patient, the mandibular HCC metastasis presented as a welldefined lobulated soft tissue mass with bone destruction.…”

Section: Discussionmentioning

confidence: 65%

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Haemorrhagic Complication of Mandibular Metastasis of Hepatocellular Carcinoma Controlled by Endovascular Embolisation

Lee¹,

Chu²,

Leung³

et al. 2014

Hong Kong J Radiol

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Mandibular metastasis in hepatocellular carcinoma is rarely seen. Since the first case reported in 1957, only about 70 cases have been reported. To the best of our knowledge, only two cases presenting with acute haemorrhage episodes have been reported in the literature, despite the fact that hepatocellular carcinoma is a hypervascular tumour. Moreover, only one of the cases was managed with endovascular embolisation, which did not completely control the haemorrhage. We, hereby, present a case of a 65-year-old man with known hepatocellular carcinoma with metastasis to the mandible complicated by uncontrollable haemorrhage from the tumour, which was effectively controlled by endovascular embolisation. Angiographic anatomy and endovascular treatment of this rare site of metastasis are also illustrated.

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Section: Discussionmentioning

confidence: 65%

“…Blood flow slows down in this area, allowing metastatic deposits. 6 There are two postulated pathways of spread from liver to the maxillofacial area. One involves the communication between the hepatic artery and portal vein, in which the lungs are reached first.…”

Section: Discussionmentioning

confidence: 99%

Haemorrhagic Complication of Mandibular Metastasis of Hepatocellular Carcinoma Controlled by Endovascular Embolisation

Lee¹,

Chu²,

Leung³

et al. 2014

Hong Kong J Radiol

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“…HCC occurs most frequently in elderly males with alcoholic liver cirrhosis. In total, >50% of HCC cases result in extrahepatic metastases (6,7), which occur most frequently in the lungs, adrenal glands and regional lymph nodes (8,9), but rarely in the lacrimal gland. Metastases to the lacrimal gland are extremely rare, however, when they do occur, they appear as exophytic tumors, and rarely with bone changes.…”

Section: Discussionmentioning

confidence: 99%

Hepatocellular carcinoma metastasis to the lacrimal gland: A case report

Chen

Wang³

et al. 2014

Oncology Letters

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Hepatocellular carcinoma (HCC) is a globally common neoplasm, with regional metastasis associated with >50% of the tumors. Extrahepatic metastasis is also common, with the lungs, diaphragm, abdominal lymph nodes and bone being the most frequently affected regions. However, to the best of our knowledge, HCC metastasis to the lacrimal gland has not been reported in the literature. Only one case of metastasis to the lacrimal sac from a renal cell carcinoma has been reported. The current study presents the case of a 56-year-old male with ocular symptoms who was eventually diagnosed with HCC. The therapeutic alternatives for such cases are also discussed according to the reviewed literature. Clinicians should be watchful for the appearance of tumors in the lacrimal gland in patients with a history of malignancy.

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“…3 Since then approximately 50 further cases have been reported in the literature. 2 Of the primary tumours known to metastasize to the oral cavity, thyroid, lung and kidney are more frequently encountered than other such primaries. 4 Of these, cancers of both lung and kidney are known to spread more commonly to the maxilla than other solid tumours.…”

Section: Discussionmentioning

confidence: 99%

“…1 However, in hepatocellular carcinoma (HCC) approximately 50% exhibit extrahepatic spread to other organs, such as brain, lungs, diaphragm and adrenal glands. 1,2 The aim of this report is to highlight a rare case of metastatic HCC to the oral cavity.…”

Section: Introductionmentioning

confidence: 99%

Hepatocellular carcinoma metastasis to the maxilla: a rare case

Greenstein¹,

Witherspoon²,

Iqbal³

et al. 2013

Australian Dental Journal

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The manifestation of metastatic malignant disease in the oral cavity can present in a number of ways and may mimic benign conditions. This case reports a rare presentation from a metastasis of a hepatocellular carcinoma that had invaded the attached gingiva of the maxilla and which on initial inspection could have been misdiagnosed as a pyogenic granuloma. With the advent of new classes of drugs to manage this disease it could be expected that this presentation may become more common.

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Metastasis of Hepatocellular Carcinoma into the Mandible with Radiographic Findings Mimicking a Radicular Cyst: A Case Report

Cited by 15 publications

References 27 publications

Haemorrhagic Complication of Mandibular Metastasis of Hepatocellular Carcinoma Controlled by Endovascular Embolisation

Haemorrhagic Complication of Mandibular Metastasis of Hepatocellular Carcinoma Controlled by Endovascular Embolisation

Hepatocellular carcinoma metastasis to the lacrimal gland: A case report

Hepatocellular carcinoma metastasis to the maxilla: a rare case

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