2021
DOI: 10.1016/j.ejps.2020.105603
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Methylene blue analogues: In vitro antimicrobial minimum inhibitory concentrations and in silico pharmacophore modelling

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Cited by 19 publications
(12 citation statements)
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“…Dark control with free MB treatment also led to substantial inhibition of Chlamydia growth upon reinfection of HeLa cells indicating the anti-chlamydial effect of this dye. Interestingly, the bactericidal effect of MB was reported earlier for different bacterial species in several studies, although its molecular mechanisms remain elusive. It should be noted that we did not detect here a significant reduction of Chlamydia titer in RAW264.7 cells treated with empty nanoMOFs (Figure B–D).…”
Section: Resultsmentioning
confidence: 92%
“…Dark control with free MB treatment also led to substantial inhibition of Chlamydia growth upon reinfection of HeLa cells indicating the anti-chlamydial effect of this dye. Interestingly, the bactericidal effect of MB was reported earlier for different bacterial species in several studies, although its molecular mechanisms remain elusive. It should be noted that we did not detect here a significant reduction of Chlamydia titer in RAW264.7 cells treated with empty nanoMOFs (Figure B–D).…”
Section: Resultsmentioning
confidence: 92%
“…Dark control with free MB treatment also led to substantial inhibition of Chlamydia growth upon reinfection of HeLa cells indicating antichlamydial effect of this dye. Interestingly, bactericidal effect of MB was reported earlier for different bacteria species in several studies, [35][36][37] although its molecular mechanisms remain elusive. It should be noted that we did not detect here a significant reduction of Chlamydia titer in RAW264.7 cells treated with empty nanoMOFs (Figure 7B-D).…”
Section: Photodynamic Effect Of Mil-100(fe)/mb Nanoparticles In Infec...mentioning
confidence: 96%
“…Likewise, the results indicate that ketorolac is strongly retained in the polymeric matrix, due to intermolecular forces, mainly hydrogen bonds, which limits its release under these conditions. Figure 7(b) shows the release profiles of the antimicrobial methylene blue [34], where in all the matrices under study, they present an accelerated release during the first 30 min, and then a slower release (sustained release [35]) during the hours after being in contact with the medium (PBS 1X). The CXG15 and CGX20 hydrogels loaded with this molecule exhibit the highest release within the first hour of being in contact with the medium, 2.13 ± 0.08 µg ml −1 and 2.36 ± 0.07 µg ml −1 , respectively.…”
Section: Encapsulated Drug Release Studymentioning
confidence: 99%