Micro- and nanopatterning of biomaterial surfaces

Sahin, Onur; Ashokkumar, Meiyazhagan; Ajayan, Pulickel M.

doi:10.1016/b978-0-08-102205-4.00003-9

Cited by 24 publications

(19 citation statements)

References 49 publications

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“…However, for submicron resolution across two dimensions, photolithography or e-beam lithography is more adequate. Photolithography was the second most used technique in the review (13.6%) [ 51 , 56 , 57 ], being considered powerful not only to create a master mold but also as a stand-alone method that can offer micron-resolution patterns across a large area of the substrate [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

The Advances in Glioblastoma On-a-Chip for Therapy Approaches

Alves

Nucci

Mamani

et al. 2022

Cancers

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This systematic review aimed to verify the use of microfluidic devices in the process of implementing and evaluating the effectiveness of therapeutic approaches in glioblastoma on-a-chip, providing a broad view of advances to date in the use of this technology and their perspectives. We searched studies with the variations of the keywords “Glioblastoma”, “microfluidic devices”, “organ-on-a-chip” and “therapy” of the last ten years in PubMed and Scopus databases. Of 446 articles identified, only 22 articles were selected for analysis according to the inclusion and exclusion criteria. The microfluidic devices were mainly produced by soft lithography technology, using the PDMS material (72%). In the microenvironment, the main extracellular matrix used was collagen type I. Most studies used U87-MG glioblastoma cells from humans and 31.8% were co-cultivated with HUVEC, hCMEC/D3, and astrocytes. Chemotherapy was the majority of therapeutic approaches, assessing mainly the cellular viability and proliferation. Furthermore, some alternative therapies were reported in a few studies (22.6%). This study identified a diversity of glioblastoma on-a-chip to assess therapeutic approaches, often using intermediate levels of complexity. The most advanced level implemented the intersection between different biological systems (liver–brain or intestine–liver–brain), BBB model, allowing in vitro studies with greater human genetic similarity, reproducibility, and low cost, in a highly customizable platform.

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Section: Discussionmentioning

confidence: 99%

The Advances in Glioblastoma On-a-Chip for Therapy Approaches

Alves

Nucci

Mamani

et al. 2022

Cancers

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“…One of the drawbacks of the soft lithographic method is that it requires another lithography method to fabricate the stamp master. If the process is done once and it can be repeatedly used to patter the surfaces [45]. Scanning probe lithography feels the surface to image and modifies the surface with atomic resolution.…”

Section: Lithographymentioning

confidence: 99%

Nanomaterials: Synthesis and Applications in Theranostics

et al. 2021

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Nanomaterials are endowed with unique features and essential properties suitable for employing in the field of nanomedicine. The nanomaterials can be classified as 0D, 1D, 2D, and 3D based on their dimensions. The nanomaterials can be malleable and ductile and they can be drawn into wires and sheets. Examples of nanomaterials are quantum dots (0D), nanorods, nanowires (1D), nanosheets (2D), and nanocubes (3D). These nanomaterials can be synthesized using top-down and bottom-up approaches. The achievements of 0D and 1D nanomaterials are used to detect trace heavy metal (e.g., Pb2+) and have higher sensitivity with the order of five as compared to conventional sensors. The achievements of 2D and 3D nanomaterials are used as diagnostic and therapeutic agents with multifunctional ability in imaging systems such as PET, SPECT, etc. These imaging modalities can be used to track the drug in living tissues. This review comprises the state-of-the-art of the different dimensions of the nanomaterials employed in theranostics. The nanomaterials with different dimensions have unique physicochemical properties that can be utilized for therapy and diagnosis. The multifunctional ability of the nanomaterials can have a distinct advantage that is used in the field of theranostics. Different dimensions of the nanomaterials would have more scope in the field of nanomedicine.

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“…The polymer PDMS is the standard material to create the stamp due to its elasticity, hydrophobicity, biocompatibility, and optical transparency [ 75 ]. Nonetheless, it is possible to transfer the pattern using other elastomeric materials such as polyurethane, polyamide, phenol-formaldehyde polymers, and specific siloxane polymer formulations for high-resolution applications [ 76 , 77 ].…”

Section: Mimicking the Spatial And Physical Components Of The Stem Cell Microenvironmentmentioning

confidence: 99%

The Use of Microfabrication Techniques for the Design and Manufacture of Artificial Stem Cell Microenvironments for Tissue Regeneration

et al. 2021

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The recapitulation of the stem cell microenvironment is an emerging area of research that has grown significantly in the last 10 to 15 years. Being able to understand the underlying mechanisms that relate stem cell behavior to the physical environment in which stem cells reside is currently a challenge that many groups are trying to unravel. Several approaches have attempted to mimic the biological components that constitute the native stem cell niche, however, this is a very intricate environment and, although promising advances have been made recently, it becomes clear that new strategies need to be explored to ensure a better understanding of the stem cell niche behavior. The second strand in stem cell niche research focuses on the use of manufacturing techniques to build simple but functional models; these models aim to mimic the physical features of the niche environment which have also been demonstrated to play a big role in directing cell responses. This second strand has involved a more engineering approach in which a wide set of microfabrication techniques have been explored in detail. This review aims to summarize the use of these microfabrication techniques and how they have approached the challenge of mimicking the native stem cell niche.

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Micro- and nanopatterning of biomaterial surfaces

Cited by 24 publications

References 49 publications

The Advances in Glioblastoma On-a-Chip for Therapy Approaches

The Advances in Glioblastoma On-a-Chip for Therapy Approaches

Nanomaterials: Synthesis and Applications in Theranostics

The Use of Microfabrication Techniques for the Design and Manufacture of Artificial Stem Cell Microenvironments for Tissue Regeneration

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