Microbiological Advances in Bioactives from High Altitude

Phulara, Suresh Chandra; Ahmad, Naeem; Mazumdar, Bidyut; Rajput, Vikrant Singh

doi:10.1007/978-981-15-1902-4_17

Cited by 4 publications

(3 citation statements)

References 218 publications

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“…In addition to this, secondary metabolites also i) provide characteristic properties, such as fragrance, flavour, and medicinal values to plants ii) help to attract pollinators, iii) acts as pheromone in insects etc 9 . For example, the plant pigments like capsaicin, beta-carotene, lycopene, and curcumin are secondary metabolites and produced as a result of metabolic pathways in the plant involving a specific set of primary metabolites, such as acetyl-coA, pyruvate, amino acids etc 10 .…”

Section: Fig 1: Schematic Representation Of Central Dogma (Transcription and Translation) And Constituents Of Metabolome (Amino Acids Sugmentioning

confidence: 99%

“…In the above mentioned context, stratified medicine helped to precision medicine, where treatment is specific and predefined for each patient according to their medical history and other clinical features. In this respect, there are a set of plant derived secondary metabolites like vinblastine, peclitaxel, artemisinin, curcumin, carotenoids etc, which are of medicinal importance 10,15 . These metabolites can also be produced using GRAS (generally regarded as safe) status microbes, such as Bacillus subtilis and Corynebacterium glutamicum by modulating their respective metabolic pathways 16,17 so that they can be utilized as live therapeutics.…”

Section: Role Of Metabolites In Precision Medicinementioning

confidence: 99%

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Impact of Metabolic Regulation in Understanding the Status of Human Health and Diseases: A Review

Siddiqui¹,

Bhavana²,

Sarvani³

2022

Int J Life Sci Pharm Res

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The concept of metabolic regulations deals with the varied and innumerable metabolic pathways that are present in the human body. A combination of such metabolic reactions paves the way for the proper functioning of different physiological and biological functions. Dealing with the adversities of a disease, engineering of novel metabolic pathways showcase the potential of metabolic engineering and its applications in the therapeutic treatment of diseases. A proper and deeper understanding of the metabolic functions in the human body can be known from gut-microflora and simulated yeast models. At molecular level, the metabolic regulation works mainly by modulation of the activities of the enzyme. This gives a brief understanding about the interactions between the molecular set of metabolomes and its complexity. The idea of model simulation can help us to draw some possible hypotheses regarding how different the components of a certain pathway are connected. Introduction of engineered microorganisms into the gut might bring about the required variation in the microbiota, thereby inducing them to express certain biomarkers specific to certain microbial groups forming a basis for disease diagnosis and pathogenesis. Since the metabolic homeostasis and observable phenotype are linked to each other, metabolism can be used as a diagnostic of the phenotype. The present review, therefore, focuses on the importance of both the gut-microbiota and yeast model in improving our understanding about the metabolic regulations involved in human health and disease.

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Section: Fig 1: Schematic Representation Of Central Dogma (Transcription and Translation) And Constituents Of Metabolome (Amino Acids Sugmentioning

confidence: 99%

Section: Role Of Metabolites In Precision Medicinementioning

confidence: 99%

Impact of Metabolic Regulation in Understanding the Status of Human Health and Diseases: A Review

Siddiqui¹,

Bhavana²,

Sarvani³

2022

Int J Life Sci Pharm Res

View full text Add to dashboard Cite

show abstract

“…Meanwhile, its leaf extracts have been exploited as an aboriginal remedy for various disorders, including cancer and infectious diseases. − Cocoa ( Theobroma cacao L.) belongs to the Sterculiaceae family and serves as an important economic crop in many African and Asian countries. , Cocoa powder has been used as a curative agent in the pathogenesis of several chronic diseases . For instance, approximately two spoons of cocoa powder in a cup of water or milk was used as a palliative treatment for Parkinson’s disease, mastitis, − liver diseases, sexual dysfunction, fever, cystitis, cold, burns, asthma, bronchitis, diabetes, and obesity. − In combination with other materials, a cocoa drink has been found to decrease the level of cholesterol in rats …”

Section: Introductionmentioning

confidence: 99%

Influence of Extractive Solvents on the Chemical Composition and Antioxidative Properties of Blends from Carica papaya Leaves and Alkalized Cocoa Powder

Oluwajuyitan

Malomo

Badejo

et al. 2020

ACS Food Sci. Technol.

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The demand for low-cost and functional drinks is growing in most of the developing world, where starchy (mainly sugar) foods are the basic staples. In this study, the proximate composition, antioxidant, and phytochemical properties of the extracts from alkalized cocoa powder (ACP) and Carica papaya leaves were determined after blending and mixing them with aqueous and ethanol solvents. The level of crude fiber of the blends was 5-fold higher in 100% C. papaya leaves than in 75% ACP, but the ACP gave a 50% increase in protein content. Notably, C. papaya leaves in the ethanol extract gave higher free DPPH (77.54−85.5%), hydroxyl (83.86−94.16%), and radical scavenging and high metal chelating (32.35−55.82%) activities than the aqueous extract (72.07−83.26%, 71.28−89.83%, and 21.45−56.86%, respectively). On the contrary, ACP increased the phytochemical profiles (total flavonoid, tannin, and total phenols) of the extracts (1.76−2.56%, 12.47−20.58 mg/g, and 11.47−19.01 mg/g, respectively). Hence, the blends are laden with antioxidants that can provide health benefits to consumers.

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The inhibition effect of natural food supplement active ingredients on TP63 carcinoma cell

Gökalp

2020

Med Oncol

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Microbiological Advances in Bioactives from High Altitude

Cited by 4 publications

References 218 publications

Impact of Metabolic Regulation in Understanding the Status of Human Health and Diseases: A Review

Impact of Metabolic Regulation in Understanding the Status of Human Health and Diseases: A Review

Influence of Extractive Solvents on the Chemical Composition and Antioxidative Properties of Blends from Carica papaya Leaves and Alkalized Cocoa Powder

The inhibition effect of natural food supplement active ingredients on TP63 carcinoma cell

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