Micropapillary carcinoma of the parotid gland arising in mucinous cystadenoma

Michal, Michael; Skálová, Alena; Mukenšnábl, Petr

doi:10.1007/s004280000274

Cited by 54 publications

(21 citation statements)

References 16 publications

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“…12 Patients with micropapillary patternpositive lung adenocarcinomas have poor prognosis and tend to present with extensive lymph node involvement and metastatic disease, [12][13][14][15] similar to patients with micropapillary carcinomas of the breast, 23 urinary bladder, 24,25 ureter 26,27 and parotid gland. 28,29 However, little is known about the mechanisms involved in micropapillary patternassociated lymph node metastasis. In our study, nodal metastasis, tumor size (41 cm in diameter) and pleural invasion were significantly more frequent in micropapillary pattern-positive cases than in micropapillary pattern-negative cases.…”

Section: Discussionmentioning

confidence: 99%

Micropapillary pattern and grade of stromal invasion in pT1 adenocarcinoma of the lung: usefulness as prognostic factors

et al. 2007

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Recently, the stromal invasion grading system was proposed for small adenocarcinomas of r2.0 cm. The system is based on the presence or absence of a fibrotic focus, and the extent of invasion into the fibrotic focus. Although stromal invasion grading system closely correlated with the prognosis, stromal invasion grade 3, representing stromal invasion into the center of a fibrotic focus, was the largest group of tumors and showed variable prognosis. In this study, we investigated whether stromal invasion grading system could be applied to and validated in pT1 adenocarcinomas as the TNM classification is the most universally used system. Furthermore, we investigated whether stromal invasion grade 3 cases could be subclassified according to the presence and absence of micropapillary pattern. The study included 120 cases of pT1 lung adenocarcinomas, of which 81 (68%) cases were stromal invasion grade 3. Micropapillary pattern was positive in 80% of grade 3 cases. For stromal invasion grade 3 cases, the 5-year survival rate of patients with micropapillary patternpositive carcinomas was 63%, which was significantly worse than 94% of those with micropapillary patternnegative carcinomas (P ¼ 0.0196). The latter was very close to that for patients with stromal invasion grade 0-2 (95%). Moreover, small cluster invasion was observed at sites of stromal invasion significantly more often in micropapillary pattern-positive cases than negative cases. Thus, the stromal invasion grading system is reproducible and correlates with prognosis even in pT1 lung adenocarcinomas. Moreover, among patients with stromal invasion grade 3 carcinomas, favorable prognosis is noted in micropapillary pattern-negative cases. The micropapillary pattern subclassification provides an advantage to the stromal invasion grading system and reconfirms the importance of micropapillary pattern as a prognostic marker. Our study is the first to point to the possible association of micropapillary pattern-positive carcinomas and small cluster invasion.

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Section: Discussionmentioning

confidence: 99%

Micropapillary pattern and grade of stromal invasion in pT1 adenocarcinoma of the lung: usefulness as prognostic factors

et al. 2007

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“…A case of malignant transformation to invasive micro papillary adenocarcinoma in mucinous cystadenoma of parotid gland has been reported [29] but no such case has been reported in minor salivary glands.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case Report of Mucinous Cystadenoma with Immunohistochemical Analysis and Review of Literature

Girotra

Padhye

Mahajan

et al. 2014

J. Maxillofac. Oral Surg.

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Cystadenomas are rare salivary gland tumours characterised by prominent epithelium-lined papillary projections into the cystic spaces. A 37 year-old female, presented with a swelling on the right side of the hard palate. Clinically, the swelling was soft, fluctuant, sessile and non-tender measuring 2.5 9 2 cm in diameter. Excisional biopsy was performed. The histopathological and immunohistochemical features were characteristic of mucinous cystadenoma. There has been no recurrence over a 2-year follow up period. The article highlights its clinical, histopathological, immunohistochemical features and differential diagnosis along with review of literature. Cystadenoma of the palate is rare, papillary variety being more common than mucinous with very few cases reported in literature.

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“…Subsequently, micropapillary carcinoma has been reported and described in the urinary bladder, [3][4][5][6] ureter, 7 and ovary 8 and further in the breast. [9][10][11][12][13][14][15] Micropapillary carcinoma has also been reported in association with a parotid gland mucinous cystadenoma 16 …”

Section: Discussionmentioning

confidence: 99%

Fine Needle Aspiration Cytologic Findings of Micropapillary Carcinoma in the Lung

Duncan¹,

Jacob²,

Atkinson³

2007

Acta Cytologica

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Micropapillary carcinoma of the parotid gland arising in mucinous cystadenoma

Cited by 54 publications

References 16 publications

Micropapillary pattern and grade of stromal invasion in pT1 adenocarcinoma of the lung: usefulness as prognostic factors

Micropapillary pattern and grade of stromal invasion in pT1 adenocarcinoma of the lung: usefulness as prognostic factors

A Rare Case Report of Mucinous Cystadenoma with Immunohistochemical Analysis and Review of Literature

Fine Needle Aspiration Cytologic Findings of Micropapillary Carcinoma in the Lung

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