Micropipe flow visualization using digital in-line holographic microscopy

Verrier, Nicolas; Remacha, Clément; Brunel, Marc; Lebrun, Denis; Coëtmellec, Sébastien

doi:10.1364/oe.18.007807

Cited by 36 publications

(17 citation statements)

References 29 publications

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“…2). Furthermore, DIH has also been applied to other research fields, such as microfluidics for flow field visualization 22,29,41 and interferometry for measurement of deformation of soft materials. 13,19,20,26 …”

Section: Overview Of Lens-free Imaging Systems and Their Applicationsmentioning

confidence: 99%

Lens-Free Imaging for Biological Applications

et al. 2012

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Lens-free (or lensless) imaging is emerging as a cost-effective, compact, and lightweight detection method that can serve numerous biological applications. Lens-free imaging can generate high-resolution images within a field-portable platform, which is ideal for affordable point-of-care devices aiming at resource-limited settings. In this mini-review, we first describe different modes of operation for lens-free imaging and then highlight several recent biological applications of this emerging platform technology.

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Section: Overview Of Lens-free Imaging Systems and Their Applicationsmentioning

confidence: 99%

Lens-Free Imaging for Biological Applications

et al. 2012

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“…Later improvements in large photosensitive detectors arrays such as CCD (Charge-Coupled Device) and CMOS (Complementary Metal Oxide Semiconductor) cameras, associated to an increase in computing power, made possible its digital and dynamic implementation for many industrial purposes such as deformation measurements and vibrometry [89,90,94], flow visualization [95], removal of wavefront distortions in optical communications [67] and high density data storage [46], among others.…”

Section: Holographic Microscopy For Far-field Optical Mappingmentioning

confidence: 99%

Metallic Nanoparticles

2008

Metallic Nanoparticles

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iii Dans un cadre plus personnel, je remercie mes supercopines du labo: Emilie, Daria, Camille et Anne. Nos activités multiples en dehors du labo ont adouci les coups intrinsèquesà la thèse: des brunchs, des ateliers cuisine, des sessions de PPG et zumba, la piscine, de nombreuses soirées. . . Et bien sûr je remercie aussi mes copains masculins, toujours plus nombreux dans notre domaine, avec lesquels nous avons aussi partagé des très bons moments aussi bienà l'intérieur qu'à l'extérieur du labo: Baptiste, Olivier, Pierre, Nico et Marc. La plupart d'entre eux travaillent et vivent déjà ailleurs; le reste sont, comme moi, en train de dire au revoirà uneépoque importante. Mais mon départ me fait d'autant plus peine car j'ai aussi croisé des gens top sur la fin de cette thèse dont la plupart sont toujoursà Langevin. Heureusement, je suis sûre de revoir François, Fish, Mai, Clément, Nikos, Gautier, Jerôme et Marion sur les pistes de danse! Enfin, je remercie ma famille ainsi que ma famille politique pour leur soutien inconditionnel. Malgré la distance, ils sont restés très près de moi dans les moments les plus importants ces trois dernières années. Un sincère merci aussià mes copains catalans pour leur soutient, compréhension et fidélité de là où ils se trouvent. Cette réussite est aussi grâceà eux et je les porte dans mon coeur partout où je vais. iv AbstractIn this thesis work, we present a novel stochastic microscopy technique based on Digital Holography for the 3D mapping of optical intensity distributions. We show that this far-field, wide-field, 3D microscopy can be turned into both a superresolution and a nearfield imaging technique. To do so, we use metallic nanoparticles undergoing Brownian motion as stochastic local field probes that we localize in three-dimensions in order to overcome the diffraction limit. The random motion of the particles allows for a complete exploration of the sample. Beyond simple localization, the gold markers can actually be envisaged as extremely local electromagnetic field probes, able to scatter light into the far-field. The technique we propose here is therefore a combination of the concepts of superlocalization and NSOM microscopies. The possibilities of the technique are illustrated through the 3D optical mapping of an evanescent and a propagative wave.Fast computation methods allow us to localize hundreds of particles per minute with accuracies as good as 3 × 3 × 10 nm 3 for immobilized particles. In addition to optical intensity mapping, we show a particular application in electrochemistry, by coupling our high resolution images with electrochemical oxidation measurements on silver nanoparticles in solution at the vicinity of an electrode.Our results pave the way for a new subwavelength imaging technique, well adapted to optical characterization in water-based systems (such as in emerging microfluidics studies), which are mostly inaccessible to electron microscopy or local probe microscopies.

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“…This technique now has applications in a large number of domains from investigation of particles in flows [2][3][4][5][6][7], to visualization of cells in biology or medicine, to phase contrast metrology, or to detection of nanoparticles without being exhaustive [8][9][10][11][12][13][14]. Research activities in this field have many orientations: some articles treat the elaboration of models to compute and predict holograms.…”

Section: Introductionmentioning

confidence: 99%

Numerical Models for Exact Description of in-situ Digital In-Line Holography Experiments with Irregularly-Shaped Arbitrarily-Located Particles

et al. 2015

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We present the development of a numerical simulator for digital in-line holography applications. In-line holograms of arbitrarily shaped and arbitrarily located objects are calculated using generalized Huygens-Fresnel integrals. The objects are 2D opaque or phase objects. The optical set-up is described by its optical transfer matrix. A wide variety of optical systems, involving windows, spherical or cylindrical lenses, can thus be taken into account. It makes the simulator applicable for design and description of in situ experiments. We discuss future applications of this simulator for detection of nanoparticles in droplets, or calibration of airborne instruments that detect and measure ice crystals in the atmosphere.

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Micropipe flow visualization using digital in-line holographic microscopy

Cited by 36 publications

References 29 publications

Lens-Free Imaging for Biological Applications

Lens-Free Imaging for Biological Applications

Metallic Nanoparticles

Numerical Models for Exact Description of in-situ Digital In-Line Holography Experiments with Irregularly-Shaped Arbitrarily-Located Particles

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