MicroRNA-497 inhibits thyroid cancer tumor growth and invasion by suppressing BDNF

Wang, Peisong; Meng, Xiangchuan; Huang, Yan; Lv, Zhi Dong; Liu, Jia; Wang, Guimin; Wang, Meng; Xue, Shuai; Zhang, Qiang; Zhang, Pengju; Chen, Guang

doi:10.18632/oncotarget.13747

Cited by 42 publications

(46 citation statements)

References 35 publications

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“…In the context of PTC, accumulating evidence suggested that the abnormal expression of miRNAs play a pivotal role in the development and progression of PTC (Leonardi et al, ; Aragon Han et al, ). For instance, a previous study found that miR‐497 exhibits its anti‐proliferative and anti‐metastatic effects on thyroid cancer by repressing BDNF and its downstream signaling pathways (PI3K/AKT) (Wang et al, ). Wen et al .…”

Section: Discussionmentioning

confidence: 99%

Retracted: MiR‐141‐3p Suppresses Tumor Growth and Metastasis in Papillary Thyroid Cancer via Targeting Yin Yang 1

Fang

Huang

et al. 2018

The Anatomical Record

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has been found to be downregulated in papillary thyroid carcinoma (PTC), while little is known about the cellular functions and precise signals elicited by miR-141-3p in PTC. The results of this study indicated that the expression of miR-141-3p was aberrantly down-regulated in PTC tissues and cell lines, compared with the adjacent normal tissues and normal thyroid epithelial cells. Furthermore, the miR-141-3p expression level was negatively associated with TNM stage and lymph node metastasis in PTC. Expression of miR-141-3p effectively inhibited cell growth, promoted apoptosis, and suppressed invasion in PTC cells. Meanwhile, miR-141-3p knockdown with miR-141-3p inhibitor reversed these effects. Consistent with the in vitro study, miR-141-3p also exhibited anti-neoplastic activity in vivo. Moreover, the results revealed that miR-141-3p directly recognized the 3 0 untranslated region (3 0 UTR) of Yin Yang 1 (YY1) and negatively regulated the expression of YY1 at both protein and mRNA levels. Ectopic expression of YY1 could effectively abrogate the anti-metastatic and proapoptotic effects of miR-141-3p. In summary, the findings suggested that miR-141-3p can act as a tumor suppressor in PTC and may be a potential therapeutic target for PTC treatment. Anat Rec, 302:258-268, 2019. -3p; YY1; tumor growth; metastasis 10%-15% of patients will relapse and develop distant metastases, leading to a poor clinical outcome (Sipos and Mazzaferri, 2010). Thus, further exploring the underlying mechanisms contributing to the occurrence, progression, and metastasis of PTC may provide insight into the novel target therapies. MicroRNAs (miRNAs) belong to a group of small noncoding RNA, and play a pivotal role in various physiological and pathological processes during cancer development

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Section: Discussionmentioning

confidence: 99%

Retracted: MiR‐141‐3p Suppresses Tumor Growth and Metastasis in Papillary Thyroid Cancer via Targeting Yin Yang 1

Fang

Huang

et al. 2018

The Anatomical Record

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“…Study of osteosarcoma cells revealed that the inhibitory impact of miR‐497‐5p on proliferation and invasion of human MG‐63 osteosarcoma cells could be mediated by downregulation of angiomotin (Ruan, Wang, Feng, Xue, & Zhang, 2016). Overexpression of miR‐497‐5p in human thyroid cell line TPC‐1 suppressed a brain‐derived neurotrophic factor expression following inhibition of tumor growth and invasion (Wang et al, 2017). Analysis of miR‐497‐5p in colorectal cancer patients indicated a significant downregulation of miR‐497‐5p in CRC tumors (Guo et al, 2013; Qiu et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Overexpression of miR-497-5p in human thyroid cell line TPC-1 suppressed a brain-derived neurotrophic factor expression following inhibition of tumor growth and invasion (Wang et al, 2017). Analysis of miR-497-5p in colorectal cancer patients indicated a significant downregulation of miR-497-5p in CRC tumors (Guo et al, 2013;Qiu et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

miR‐497‐5p mediates starvation‐induced death in colon cancer cells by targeting acyl‐CoA synthetase‐5 and modulation of lipid metabolism

Gharib

Nasrabadi

Zali

2020

Journal Cellular Physiology

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Modulation of fatty acids metabolism is an appropriate strategy for starvation‐induced death in tumor cancers. Colon cancer cells express a high level of acyl‐CoA synthetase‐5 (ACSL5), and as yet no therapeutic approach has been achieved. Herein, ACSL5‐related microRNAs (miRNAs) were identified via TargetScan, and their impacts on ACSL5 and lipid content along with metabolic activity, cell cycle, migration, and invasion of colorectal cancer (CRC) cells were examined, and subsequently compared with transcriptome for better visualization of intracellular‐signaling networks. In vivo analysis was performed using BALB/c mice xenograft model of CRC injected with target miRNA. Clinical significances were also evaluated in 80 CRC tumors and matched adjacent normal tissues. There was a reverse correlation between ACSL5 and miR‐497‐5p, which miR‐497‐5p overexpression modulated CRC cell proliferation and development. A similar observation was received from the in vivo examination in which intratumoral injection of miR‐497‐5p reversed the tumor growth in the CRC xenograft model. Downregulation of miR‐497‐5p correlated with tumor differentiation, tumor, node, and metastasis staging, lymph node metastasis, and poor survival in patients with CRC. These results suggested that miR‐497‐5p upregulation could be considered as a therapeutic strategy for modulation of lipid metabolism in colon cancer.

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“…A previous study revealed that miR-141 suppressed TC cell growth and metastasis by suppressing insulin receptor substrate 2, indicating that miR-141 may serve as a potential therapeutic target for the treatment of patients with TC (31). Furthermore, miR-497 is also considered to be a TC tumor suppressor that acts by repressing brain derived neurotrophic factor (32). A previous study also indicated that miR-7 may function as a tumor suppressor by directly targeting serine/threonine protein kinase 1, potentially serving as a novel therapeutic target for TC (30).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‑30a suppresses papillary thyroid cancer cell proliferation, migration and invasion by directly targeting E2F7

Guo

Zhang

2019

Exp Ther Med

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microRNA (miRNA/miR)-30a, a tumor-associated miRNA, has been implicated in the tumorigenesis and progression of different types of human cancer. Thyroid cancer is a common endocrine malignancy, of which papillary thyroid cancer (PTC) accounts for ~80-90% of all TC. However, the effect of miR-30a in PTC is yet to be fully elucidated. The TPC-1 human PTC cell line, as well as the normal human thyroid cell line (HT-ori3), were utilized in the current study. The PTC cell line was transfected with a miR-30a mimic. Subsequently, reverse transcription-quantitative polymerase chain reaction was performed to detect the expression of miR-30a and E2F transcription factor 7 (E2F7). Cell proliferation was assessed via a MTT assay and transwell migration and invasion assays were performed to detect the migration and invasion of PTC cells. A dual-luciferase reporter assay was also utilized to clarify the association between miR-30a and E2F7. The results of the current study revealed that miR-30a was significantly downregulated in TPC-1 cells compared with HT-ori3 cells and that the expression of E2F7 was significantly upregulated in PTC cells. The upregulation of miR-30a also inhibited the proliferation, migration and invasion of PTC cells. Furthermore, the luciferase assay revealed that miR-30a binds to the 3'-UTR of E2F7. Additionally, the overexpression of miR-30a decreased E2F7 levels in TPC-1 cells. These results indicate that miR-30a functions as a tumor suppressor in PTC by direct targeting E2F7 and that miR-30a may be a novel therapeutic target for patients with PTC.

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MicroRNA-497 inhibits thyroid cancer tumor growth and invasion by suppressing BDNF

Cited by 42 publications

References 35 publications

Retracted: MiR‐141‐3p Suppresses Tumor Growth and Metastasis in Papillary Thyroid Cancer via Targeting Yin Yang 1

Retracted: MiR‐141‐3p Suppresses Tumor Growth and Metastasis in Papillary Thyroid Cancer via Targeting Yin Yang 1

miR‐497‐5p mediates starvation‐induced death in colon cancer cells by targeting acyl‐CoA synthetase‐5 and modulation of lipid metabolism

MicroRNA‑30a suppresses papillary thyroid cancer cell proliferation, migration and invasion by directly targeting E2F7

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