Microwave Photochemistry. Applications in Organic Synthesis

Cı́rkva, Vladimı́r; Relich, Stanislav

doi:10.2174/157019311796197472

Cited by 20 publications

(7 citation statements)

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“…The reactions under microwave irradiation take place in few minutes and no solvent is required [22][23][24][25]. In continution to our research for chemistry developments [26][27][28][29], we report here the use of microwave irradiation for the synthesis of 1-(1-hydroxynaphthalen-2-yl)-3-phenyl-propane-1,3-dione 3 in a quantitative yield (91%) from the reaction of α-naphthol and ethyl benzoylacetate in the presence of zinc chloride [30].…”

Section: Resultsmentioning

confidence: 99%

Microwave assisted the short time clean synthesis of 1,3-diketones as building blocks in heterocyclic synthesis: a facile synthesis and antimicrobial evaluation of new dihydropyridine, 4H-pyrane, dihydropyridazine, pyrimidine and pyrazole derivatives

2021

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The compounds bearing naphthalene moiety can be used as medical preparations because of their wide spectrum of biological activity and low toxicity. In this study, a new series of azoles or azines were synthesized from the reaction of the key intermediate 1-(1-hydroxynaphthalen-2-yl)-3-phenylpropane-1,3-dione 3 with a variety of electrophilic and nucleophilic reagents under a variety of mild conditions. The chemical structures of these compounds were confirmed by various spectroscopic methods such as (IR, 1H-NMR, 13C-NMR, mass spectra and elemental analyses). The prepared compounds were screened in vitro for their anti-microbial activity against some species of Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and Gram-negative bacteria (Escherichia coli and Pseudomonas aeuroginosa). Anti-fungal activities of the compounds were tested against yeast and mycelial fungi,Candida albicans and Aspergillus flavus. The antimicrobial activity of this series was showed either weak or moderate activities. Graphic abstract

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Section: Resultsmentioning

confidence: 99%

Microwave assisted the short time clean synthesis of 1,3-diketones as building blocks in heterocyclic synthesis: a facile synthesis and antimicrobial evaluation of new dihydropyridine, 4H-pyrane, dihydropyridazine, pyrimidine and pyrazole derivatives

2021

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“…Organic synthesis by using microwave irradiation (MW) is a new and interesting technique and is becoming popular now. The reactions under microwave irradiation takeplace in few minutes and no solvent is required [22][23][24][25]. In continution to our research for chemistry developments [26][27][28][29], we report here the use of microwave irradiation for the synthesis of 1-(1-hydroxynaphthalen-2-yl)-3phenylpropane-1,3-dione 3 in a quantitative yield (91%) from the reaction of α-naphthol and ethyl benzoylacetate in the presence of zinc chloride [30,33].…”

Section: Results and Discutionmentioning

confidence: 99%

Microwave assisted the short time clean synthesis of 1,3-Diketones as Building Blocks in Heterocyclic Synthesis: A Facile Synthesis and Antimicrobial Evaluation of New Dihydropyridine, 4H-Pyrane, Dihydropyridazine, Pyrimidine and Pyrazole derivatives

AbdElReheim

Hafiz

Rady

2019

Preprint

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Background: According to literature survey, the compounds bearing naphthalene moiety can be used as medical preparations because of their wide spectrum of biological activity and low toxicity. In this study, a new series of azoles or azines were synthesized from the reaction of the key intermediate 1-(1-hydroxynaphthalen-2-yl)-3-phenylpropane-1,3-dione 3 with a variety of electrophilic and nucleophilic reagents under a variety of mild conditions. Results: The chemical structures of these compounds were confirmed by various spectroscopic methods such as (IR, 1H-NMR, 13C-NMR, mass spectral data and elemental analyses). Conclusions: The prepared compounds were screened in vitro for their antimicrobial activity against some species of Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and Gram-negative bacteria (Escherichia coli and Pseudomonas aeuroginosa). Anti-fungal activities of the compounds were tested against yeast and mycelial fungi,Candida albicans and Aspergillus flavus. The antimicrobial activity of this series was showed either weak or moderate activities.

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“…Chemical activation by combining two different types of unconventional energy sources such as microwave‐ultrasound or microwave‐UV‐Visible radiation is the latest green‐hybrid strategy which promise to create a new discipline of chemistry giving an innovative dimension to sustainable synthesis. The deployment of these alternate energy sources has been discussed herein with a few essential and prominent applications to highlight their advantages.…”

Section: Introductionmentioning

confidence: 81%

Alternate Energy Sources for Sustainable Organic Synthesis

Mandal¹

2019

ChemistrySelect

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Organic Chemistry plays an important role in energy, information, materials, population, health, environment and implementation of defence plan. Organic chemists therefore, have the greatest responsibility to devise methods of carrying out organic syntheses, which will reduce or even eliminate the byproducts and solve the problem of environmental pollution from the source. One of the methods to achieve this is using non-conventional energy sources, such as microwave, ultrasound, and photochemical chemistry, in conjugation with nontoxic solvents, which dramatically reduces energy waste and reaction time. Experiments synergising these alternate energy sources like microwave sonication, photosonication or microwave photochemistry, have gained high popularity as costeffective green strategies. Pooling the advantages of alternate energy sources with biocatalysis is another novel avenue of sustainable synthesis. Organic electrosynthesis has also emerged as an environmentally benign technique for the construction of C-C and C-hetero bonds. Highlights of significant developments in these areas define the scope of the present discussion.

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Microwave Photochemistry. Applications in Organic Synthesis

Cited by 20 publications

References 50 publications

Microwave assisted the short time clean synthesis of 1,3-diketones as building blocks in heterocyclic synthesis: a facile synthesis and antimicrobial evaluation of new dihydropyridine, 4H-pyrane, dihydropyridazine, pyrimidine and pyrazole derivatives

Microwave assisted the short time clean synthesis of 1,3-diketones as building blocks in heterocyclic synthesis: a facile synthesis and antimicrobial evaluation of new dihydropyridine, 4H-pyrane, dihydropyridazine, pyrimidine and pyrazole derivatives

Microwave assisted the short time clean synthesis of 1,3-Diketones as Building Blocks in Heterocyclic Synthesis: A Facile Synthesis and Antimicrobial Evaluation of New Dihydropyridine, 4H-Pyrane, Dihydropyridazine, Pyrimidine and Pyrazole derivatives

Alternate Energy Sources for Sustainable Organic Synthesis

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