Mimosa Pudica Exerts Neuroprotection Against Mpp+induced Neurotoxicity in Shsy5y Cell Lines-an in Vitro Model of Anti-Parkinsonism

Mahadevan, M V; Ramaswamy, R S; Banumathi, V.

doi:10.22159/ijpps.2017v9i1.15728

Cited by 5 publications

(1 citation statement)

References 10 publications

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“…7 Mimosa pudica belonging to family Fabaceae is a creeping annual plant that has been investigated for multiple pharmacological activities such as anti-depressant, antianxiety, anti-convulsant, hepatoprotective, diuretics, anti-inflammatory, anti-oxidant, analgesic, anti-epileptic and anti-diabetes including anti-parkinsonian. [12][13][14] However, the interaction of multiple phytoconstituents with their respective targets has not been understood yet. Therefore, the current study intended to investigate the interaction between phytoconstituents from M. pudica with their respective targets including modulated pathways via network pharmacology approach.…”

Section: Introductionmentioning

confidence: 99%

Mimosa pudica Modulates Neuroactive Ligand- Receptor Interaction in Parkinson’s Disease

Duyu¹,

Khanal²,

Khatib³

et al. 2020

IJPER

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Introduction: Mimosa pudica is scientifically reported for the enhancement of memory in multiple animal models including Parkinson's disease (PD); however, the probable molecular mechanism for this effect has not been explained yet. The present study demonstrates the probable molecular mechanism to improve memory via in silico techniques. Materials and Methods: Phytoconstituents present in M. pudica and their targets involved in Parkinson's disease were identified using open-source databases and published literature. Enrichment analysis of targeted proteins was identified using STRING, druglikeness of compounds was assessed using MolSoft and docking was carried using autodock4. Results: Out of twenty-seven phytoconstituents, seventeen modulated the proteins involved in the pathogenesis of PD. Norepinephrine was predicted to have the highest druglikeness score. The ADMET profiles revealed all phytoconstituents to be safe and are suitable for human consumption. Similarly, network analysis identified ADORA1 to be primarily targeted by phytoconstituents and luteolin was predicted to interact with maximum proteins. A docking study predicted quercetin and luteolin to possess the highest binding affinity with highly modulated protein ADORA1. Conclusion: M. pudica could primarily modulate neuroactive ligand receptor interaction followed by dopamine and serotonin synapses by regulating multiple proteins in PD.

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Section: Introductionmentioning

confidence: 99%

Mimosa pudica Modulates Neuroactive Ligand- Receptor Interaction in Parkinson’s Disease

Duyu¹,

Khanal²,

Khatib³

et al. 2020

IJPER

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Medicinal plants used in traditional Mayan medicine for the treatment of central nervous system disorders: An overview

Castañeda

Cáceres²,

Velásquez

et al. 2022

Journal of Ethnopharmacology

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Mimosa pudica up-regulates dat and th proteins expression, in turn, locomotor functions in mouse mptp-1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of parkinsonism

Mv¹,

Rs²,

Banumathi³

2017

Int J Pharm Bio Sci

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Mimosa pudica is a traditional Siddha medicinal plant useful in the treatment of various neurological (vaatham) disorders. The main objective of the study is to demonstrate the neuroprotective effects of Mimosa pudica on against MPTP induced Parkinsonism in mice model. Male C57BL/6J mice (20-25 g bwt) were used for the study. Following acclimatisation the animals were divided into five groups with 6 in each. Group served as I negative control, Group II served as MPTP group, Group III as carbidopa 250 mg/kg IV & V as Mimosa pudica at 100 and 300 mg/kg, respectively. Animals were pretreated with vehicle or drugs (once a day) for five consecutive days. On day 5, one hour after vehicle or drug administration, MPTP was injected intraperitoneally at 80 mg/kg b.wt in two divided doses (2 X 40 mg/kg bwt. at 16 h interval). Forty eight hour after MPTP, animals were assessed for motor functions using horizontal grid test and vertical grid test. Then the animals were euthanised and brains were collected and processed for immunohistochemical analysis of dopamine transporter (DAT), tyrosine hydroxyalse (TH) and α-synuclein (α-syn) expressions. Mimosa pudica improved DAT and TH expressions.α-syn expression was significantly decreased in mimosa treated animals when compared to vehicle treated animals. The results indicate mimosa pudica is a potent neuro-protective agent against MPTP induced Parkinsonism.

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Mimosa Pudica Exerts Neuroprotection Against Mpp+induced Neurotoxicity in Shsy5y Cell Lines-an in Vitro Model of Anti-Parkinsonism

Cited by 5 publications

References 10 publications

Mimosa pudica Modulates Neuroactive Ligand- Receptor Interaction in Parkinson’s Disease

Mimosa pudica Modulates Neuroactive Ligand- Receptor Interaction in Parkinson’s Disease

Medicinal plants used in traditional Mayan medicine for the treatment of central nervous system disorders: An overview

Mimosa pudica up-regulates dat and th proteins expression, in turn, locomotor functions in mouse mptp-1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of parkinsonism

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