Mini Nutritional Assessment Short Form is a morbi-mortality predictor in outpatients with heart failure and mid-range left ventricular ejection fraction

Joaquín, Clara; Alonso, Núria; Lupón, Josep; Antonio, Marta de; Domingo, Mar; Moliner, Pedro; Zamora, Elisabet; Codina, Pau; Ramos, Analía; González, Beatríz; Rivas, Carmen; Cachero, Montserrat; Puig-Domingo, Manel; Bayés‐Genís, Antoni

doi:10.1016/j.clnu.2020.02.031

Cited by 21 publications

(21 citation statements)

References 16 publications

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“…Percent of body weight change and the Mini Nutritional Assessment (MNA) screening tool served as indicators of nutritional status [14]. The MNA screening tool was initially developed for detecting undernutrition in the elderly, but it has subsequently been adopted in several clinical settings and patient populations [15][16][17]. The tool identifies individuals at risk of malnutrition or malnourished based on the presence of reduction in food intake (due to loss of appetite, digestive problems, chewing or swallowing difficulties), disease burden (psychological stress or acute disease in the previous 3 months or presence of neuropsychological problems), weight loss, body mass index or reduced mobility.…”

Section: Follow-up Evaluationmentioning

confidence: 99%

Residual clinical damage after COVID-19: A retrospective and prospective observational cohort study

et al. 2020

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Data on residual clinical damage after Coronavirus disease-2019 (COVID-19) are lacking. The aims of this study were to investigate whether COVID-19 leaves behind residual dysfunction, and identify patients who might benefit from post-discharge monitoring. All patients aged �18 years admitted to the Emergency Department (ED) for COVID-19, and evaluated at post-discharge follow-up between 7 April and 7 May, 2020, were enrolled. Primary outcome was need of follow-up, defined as the presence at follow-up of at least one among: respiratory rate (RR) >20 breaths/min, uncontrolled blood pressure (BP) requiring therapeutic change, moderate to very severe dyspnoea, malnutrition, or new-onset cognitive impairment, according to validated scores. Post-traumatic stress disorder (PTSD) served as secondary outcome. 185 patients were included. Median [interquartile range] time from hospital discharge to follow-up was 23 [20-29] days. 109 (58.9%) patients needed follow-up. At follow-up evaluation, 58 (31.3%) patients were dyspnoeic, 41 (22.2%) tachypnoeic, 10 (5.4%) malnourished, 106 (57.3%) at risk for malnutrition. Forty (21.6%) patients had uncontrolled BP requiring therapeutic change, and 47 (25.4%) new-onset cognitive impairment. PTSD was observed in 41 (22.2%) patients. At regression tree analysis, the ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO 2 /FiO 2) and body mass index (BMI) at ED presentation, and age emerged as independent predictors of the need of followup. Patients with PaO 2 /FiO 2 <324 and BMI �33 Kg/m 2 had the highest odds to require follow-up. Among hospitalised patients, age �63 years, or age <63 plus non-invasive ventilation or diabetes identified those with the highest probability to need follow-up. PTSD was independently predicted by female gender and hospitalisation, the latter being protective (odds ratio, OR, 4.03, 95% confidence interval, CI, 1.76 to 9.47, p 0.0011; OR 0.37, 95% CI

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Section: Follow-up Evaluationmentioning

confidence: 99%

Residual clinical damage after COVID-19: A retrospective and prospective observational cohort study

et al. 2020

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“…The included studies utilized different types of malnutrition screening and diagnostic tools, including nutritional risk screening (NRS2000); nutritional status control (CONUT); mini nutritional assessment (MNA); Geriatric Nutritional Risk Index (GNRI); nutritional risk index (NRI); prognostic nutritional index (PNI); anthropometry (body mass index, upper arm circumference, Skinfold thickness); and biomarkers (albumin, lymphocyte count). Only two studies [ 33 , 36 ], had all-cause mortality or rehospitalization as outcome indicators for HF, while the rest only had all-cause mortality. There were three articles [ 9 , 27 , 35 ] including two methods of malnutrition assessment for assessment of prognosis.…”

Section: Resultsmentioning

confidence: 99%

The prevalence of malnutrition and its effects on the all-cause mortality among patients with heart failure: A systematic review and meta-analysis

2021

PLoS ONE

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Objective Malnutrition has a high occurrence in patients with chronic heart failure (CHF). The prevalence of malnutrition and its impact on all-cause mortality in patients with CHF were assessed using a meta-analysis. Methods PubMed, Embase, the Cochrane Library, Web of Science, Medline, CBM, CNKI, WANFANG DATA, and VIP databases were searched to collect cross-sectional and cohort studies on malnutrition, and the prevalence and all-cause mortality of patients with CHF were determined. The time of retrieval was from the database establishment to May 2021. Two researchers independently performed screening of the literature, data extraction and assessed the risk of bias in the included studies. Then Stata 16.0 software was used for meta-analysis. Results A total of 10 cross-sectional and 21 cohort studies were included, including 12537 patients with CHF. A meta-analysis demonstrated that the total prevalence of malnutrition in patients with heart failure was 46% (95% confidence interval [CI]: 0.43, 0.49). Compared to patients with non-malnutrition, malnutrition increased the risk of all-cause mortality in patients with CHF (hazard ratio = 2.15, 95% CI [1.89, 2.45], P < 0.05). Discussion Current evidence suggests that the prevalence of malnutrition is high among patients with CHF. The risk of all-cause mortality in such patients can be increased by malnutrition. Therefore, the risk of malnutrition in patients with CHF should be considered to reduce the occurrence of adverse clinical outcomes.

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“…While most nutritional risk index calculators utilize serum albumin to assess the nutritional status of patients, the mini nutritional assessment screening tool may be used to identify elderly people at risk of malnutrition prior to any decline in serum albumin levels [36]. In heart failure patients in the outpatient setting, malnutrition assessed using the Mini Nutritional Assessment screening tool was predictive of mortality [37] and was an independent predictor of all-cause mortality or heart failure-related hospitalizations in outpatients with heart failure with mid-range ejection fraction [38].…”

Section: Nutritional Risk Assessmentmentioning

confidence: 99%

How Can Malnutrition Affect Autophagy in Chronic Heart Failure? Focus and Perspectives

Corsetti

Pasini

Romano

et al. 2021

IJMS

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Chronic heart failure (CHF) is a disease with important clinical and socio-economic ramifications. Malnutrition and severe alteration of the protein components of the body (protein disarrangements), common conditions in CHF patients, are independent correlates of heart dysfunction, disease progression, and mortality. Autophagy, a prominent occurrence in the heart of patients with advanced CHF, is a self-digestive process that prolongs myocardial cell lifespan by the removal of cytosolic components, such as aging organelles and proteins, and recycles the constituent elements for new protein synthesis. However, in specific conditions, excessive activation of autophagy can lead to the destruction of molecules and organelles essential to cell survival, ultimately leading to organ failure and patient death. In this review, we aim to describe the experimental and clinical evidence supporting a pathophysiological role of nutrition and autophagy in the progression of CHF. The understanding of the mechanisms underlying the interplay between nutrition and autophagy may have important clinical implications by providing molecular targets for innovative therapeutic strategies in CHF patients.

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Mini Nutritional Assessment Short Form is a morbi-mortality predictor in outpatients with heart failure and mid-range left ventricular ejection fraction

Cited by 21 publications

References 16 publications

Residual clinical damage after COVID-19: A retrospective and prospective observational cohort study

Residual clinical damage after COVID-19: A retrospective and prospective observational cohort study

The prevalence of malnutrition and its effects on the all-cause mortality among patients with heart failure: A systematic review and meta-analysis

How Can Malnutrition Affect Autophagy in Chronic Heart Failure? Focus and Perspectives

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