MiRNA‐Wnt signaling regulatory network in colorectal cancer

Jafarzadeh, Meisam; Soltani, Bahram Mohammad

doi:10.1002/jbt.22883

Cited by 14 publications

(7 citation statements)

References 95 publications

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“…Emerging evidence has suggested that miRNAs can mediate the development of several diseases, such as CRC, through multiple genes and biological pathways (30)(31)(32). It has been reported that miRNAs are abnormally expressed in CRC tissues, thus serving as powerful and promising biomarkers for the early screening and treatment of CRC (33,34).…”

Section: Discussionmentioning

confidence: 99%

miR‑151a‑5p promotes the proliferation and metastasis of colorectal carcinoma cells by targeting AGMAT

et al. 2023

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Colorectal carcinoma (CRC) is one of the most common types of digestive cancer. It has been reported that the ectopic expression of microRNAs (miRs) plays a critical role in the occurrence and progression of CRC. In addition, it has also been suggested that miR-151a-5p may serve as a useful biomarker for the early detection and treatment of different types of cancer and particularly CRC. However, the specific effects and underlying mechanisms of miR-151a-5p in CRC remain elusive. The results of the current study demonstrated that miR-151a-5p was upregulated in CRC cell lines and clinical tissues derived from patients with CRC. Functionally, the results showed that miR-151a-5p significantly promoted CRC cell proliferation, migration and invasion. Additionally, dual luciferase reporter assays verified that agmatinase (AGMAT) was a direct target of miR-151a-5p and it was positively associated with miR-151a-5p expression. Mechanistically, miR-151a-5p could enhance the epithelial-mesenchymal transition of CRC cells. Taken together, the results of the current study revealed a novel molecular mechanism indicating that the miR-151a-5p/AGMAT axis could serve a crucial role in the regulation of CRC and could therefore be considered as a potential therapeutic strategy for CRC.

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Section: Discussionmentioning

confidence: 99%

miR‑151a‑5p promotes the proliferation and metastasis of colorectal carcinoma cells by targeting AGMAT

et al. 2023

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“…Note that HCTT116 cells are colorectal carcinoma-derived cells. Colorectal cancer is one of the common malignancies worldwide and the Wnt signaling pathway is recognized as the main disrupted pathway in this malignancy [42, 43]. Therefore, PS-SNC can detect biologically meaningful complexes in different states effectively.…”

Section: Methodsmentioning

confidence: 99%

A partially shared joint clustering framework for detecting protein complexes from multiple state-specific signed interaction networks

Zhan

Liu

et al. 2023

Preprint

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Detecting protein complexes is critical for studying cellular organizations and functions. The accumulation of protein-protein interaction (PPI) data enables the identification of protein complexes computationally. Although various computational approaches have been proposed to detect protein complexes from PPI networks, most of them ignore the signs of PPIs that reflect the ways proteins interact (activation or inhibition). As not all PPIs imply co-complex relationships, taking into account the signs of PPIs can benefit the detection of protein complexes. Moreover, PPI networks are not static, but vary with the change of cell states or environments. However, existing protein complex identification algorithms are primarily designed for single-network clustering, and rarely consider joint clustering of multiple PPI networks. In this study, we propose a novel partially shared signed network clustering model (PS-SNC) for detecting protein complexes from multiple state specific signed PPI networks jointly. PS-SNC can not only consider the signs of PPIs, but also identify the common and unique protein complexes in different states. Experimental results on synthetic and real datasets show that PS-SNC outperforms other state-of-the-art protein complex detection methods. Extensive analysis on real datasets demonstrate the effectiveness of PS-SNC in revealing novel insights about the underlying patterns of different cell lines.

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“…LncRNAs and circRNAs regulate gene expression by various mechanisms like sponging miRNAs to promote target genes. Recent studies indicate that dysregulated expression of ncRNAs promotes cancer growth and development by epigenetically regulating various oncogene or tumor suppressor genes (Chi et al, 2019[ 6 ]; Wei et al, 2020[ 55 ]; Jafarzadeh and Soltani, 2021[ 23 ]).…”

Section: Role Of Ncrnas In Tumorigenesismentioning

confidence: 99%

The interplay between non-coding RNAs and Wnt/β-catenin signaling pathway in urinary tract cancers: from tumorigenesis to metastasis

Rahmani

Safavi

Fathollahpour

et al. 2022

EXCLI Journal; 21:Doc1273; ISSN 1611-2156

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Non-coding RNAs (ncRNAs) are emerging as important regulators in various pathological conditions including tumorigenesis, metastasis, and drug resistance in human cancers. Oncogenic or tumor suppressor ncRNAs exert prominent effects on cell proliferation, migration and invasion in cancer cells through modulating various signaling pathways including Wnt/β-catenin. Upregulation of the oncogenic Wnt/β-catenin pathway was reported to be implicated in multiple human cancers including breast, liver, colorectal, and urothelial cancers. Therefore, identifying interactions between ncRNAs and canonical Wnt signaling components may represent novel therapeutic targets for better treatment and management of cancer. In this review, we summarized the recent findings about miRNA/lncRNA-dependent mechanisms that regulate Wnt/β-catenin signaling involved in tumorigenesis and metastasis of urinary tract cancers.

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MiRNA‐Wnt signaling regulatory network in colorectal cancer

Cited by 14 publications

References 95 publications

miR‑151a‑5p promotes the proliferation and metastasis of colorectal carcinoma cells by targeting AGMAT

miR‑151a‑5p promotes the proliferation and metastasis of colorectal carcinoma cells by targeting AGMAT

A partially shared joint clustering framework for detecting protein complexes from multiple state-specific signed interaction networks

The interplay between non-coding RNAs and Wnt/β-catenin signaling pathway in urinary tract cancers: from tumorigenesis to metastasis

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