Mixing in planar spiral microchannel

Duryodhan, V. S.; Chatterjee, Rajeswar; Singh, Shiv Govind; Agrawal, Amit

doi:10.1016/j.expthermflusci.2017.07.024

Cited by 40 publications

(24 citation statements)

References 17 publications

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“…In microfluidic channels with straight planar geometries, mixing occurs purely by diffusion [32]. In curved channels like those used in the mixing experiment, transverse secondary Dean flows arise due to the interaction between centrifugal and inertial forces.…”

Section: Resultsmentioning

confidence: 99%

“…Here, we demonstrate a method which combines rapid prototyping with industrial-scale roll-to-roll manufacture to produce prototype microfluidic channels, permitting rapid, lowcost screening of channel patterns for both functionality and mass-manufacturability. For proof of concept, two-stream passive fluid mixers were chosen as the ability to rapidly mix two or more reagent streams is often a required function in microfluidic setups [28][29][30][31][32]. Four different designs with standardized inlets and outlets were 3D printed from digital files, then either directly molded in PDMS or coated with a thin layer of metal and shipped to Sappi North America, Inc., for roll-to-roll casting in an acrylated coating on their industrial equipment ( Fig 1A).…”

Section: Introductionmentioning

confidence: 99%

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3D printing direct to industrial roll-to-roll casting for fast prototyping of scalable microfluidic systems

et al. 2020

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Microfluidic technologies have enormous potential to offer breakthrough solutions across a wide range of applications. However, the rate of scale-up and commercialization of these technologies has lagged significantly behind promising breakthrough developments in the lab, due at least in part to the problems presented by transitioning from benchtop fabrication methods to mass-manufacturing. In this work, we develop and validate a method to create functional microfluidic prototype devices using 3D printed masters in an industrial-scale roll-to-roll continuous casting process. There were no significant difference in mixing performance between the roll-to-roll cast devices and the PDMS controls in fluidic mixing tests. Furthermore, the casting process provided information on the suitability of the prototype microfluidic patterns for scale-up. This work represents an important step in the realization of high-volume prototyping and manufacturing of microfluidic patterns for use across a broad range of applications.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

3D printing direct to industrial roll-to-roll casting for fast prototyping of scalable microfluidic systems

et al. 2020

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“…This also causes additional mixing due to the Dean flows. Dean vortices occur due to the variation in the centrifugal forces and mixing occurs because of the velocity differences in the channel [30]. Nevertheless, spiral channel micromixing holds limitations at mixing Re ≤ 1 flows due to the weak Dean vortices [31].…”

Section: Micromixing Methodsmentioning

confidence: 99%

Microfluidic Magnetic Mixing at Low Reynolds Numbers and in Stagnant Fluids

et al. 2019

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Microfluidic mixing becomes a necessity when thorough sample homogenization is required in small volumes of fluid, such as in lab-on-a-chip devices. For example, efficient mixing is extraordinarily challenging in capillary-filling microfluidic devices and in microchambers with stagnant fluids. To address this issue, specifically designed geometrical features can enhance the effect of diffusion and provide efficient mixing by inducing chaotic fluid flow. This scheme is known as “passive” mixing. In addition, when rapid and global mixing is essential, “active” mixing can be applied by exploiting an external source. In particular, magnetic mixing (where a magnetic field acts to stimulate mixing) shows great potential for high mixing efficiency. This method generally involves magnetic beads and external (or integrated) magnets for the creation of chaotic motion in the device. However, there is still plenty of room for exploiting the potential of magnetic beads for mixing applications. Therefore, this review article focuses on the advantages of magnetic bead mixing along with recommendations on improving mixing in low Reynolds number flows (Re ≤ 1) and in stagnant fluids.

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“…Microfluidics is one of the rapidly growing areas of research having enormous applications in the fields of biomedical and chemical research. More precisely, the employment of microfluidic devices for the isolation of biological entities, micromixing, manipulation of biological entities, and drug delivery provides precise, fast, low-cost, and point-of-care solutions. − Furthermore, microfluidic-based methods overcome the drawbacks of conventional isolation techniques.…”

Section: Introductionmentioning

confidence: 99%

Biophysical Phenomenon-Based Separation of Platelet-Poor Plasma from Blood

Laxmi

Joshi

Agrawal

2021

Ind. Eng. Chem. Res.

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The extraction or isolation of biological entities on a microfluidic platform has gained considerable attention in disease diagnostics, biomedical research, and point-of-care applications. The isolation of platelet-poor plasma from blood is the first and an essential step for applications in coagulation studies. The widely known clinical methods of platelet-poor plasma separation are based on centrifugation, which require a long processing time, high power, skilled personnel, and are incompatible with point-of-care devices. The microdevice utilized in this study facilitates the employment of various biophysical phenomena, hydrodynamic forces acting on cells, and geometrical features of the microdevice for its operation. The developed microdevice is compact in size, easy to fabricate, reliable, and exhibits clog-free operation. The microdevice isolates platelet-poor plasma with a purity of 94.7 ± 1.90%, having a platelet count of 968 ± 15 per μL plasma, while operating at an inlet flow rate of 0.4 mL/min. Furthermore, biological assessment of the platelet-poor plasma extracted from the microdevice confirms that the sample is completely free from white blood cells and have no impact on the shape and size of the platelets after microfluidic processing.

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Mixing in planar spiral microchannel

Cited by 40 publications

References 17 publications

3D printing direct to industrial roll-to-roll casting for fast prototyping of scalable microfluidic systems

3D printing direct to industrial roll-to-roll casting for fast prototyping of scalable microfluidic systems

Microfluidic Magnetic Mixing at Low Reynolds Numbers and in Stagnant Fluids

Biophysical Phenomenon-Based Separation of Platelet-Poor Plasma from Blood

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