Purpose. The present study aimed to examine the intervening impact of creative self-efficacy amid learning organizations — innovative work behaviors relationships. Also, this study investigates the moderating role of self-leadership amid learning organizations — innovative work behaviors and amid creative self-efficacy — innovative work behaviors relationships. Study design. Three hundred sixty-one employees and one hundred twenty-six immediate supervisors (officers) voluntarily participate in the data collection survey from the manufacturing sector (pharmaceutical and automobile). Using different statistical software (i.e., AMOS v.22, Smart-PLS v.3, SPSS v.25, and PROCESS-macro), the hypothesized relationships (i.e., direct, indirect, moderation, and moderated mediation) were tested. Findings. The present study’s findings reveal that creative self-efficacy partially mediates the learning organizations— innovative work behaviors relationships. Also, results indicate that self-leadership moderates the learning organizations — innovative work behaviors and creative self-efficacy — innovative work behaviors relationships. Implications for practice. The present study enlightens the importance of learning organizations for enhancing innovative work behaviors in the workforce. Rapid worldwide unprecedented changes increase the competition level and require a change in the working structure. Creative self-efficacy of the employees helps the management overcome this uncertain situation through innovative behaviors. Additionally, self-leadership plays a vital role with the support of learning organizational culture and creative self-efficacy for enhancing innovative work behaviors. Value of theresults. The present study will be helpful for management by explaining how to overcome the situation of uncertain change in the business world; also, this study responds to the unanswered questions which occur in the current era, such as how organizations increase the innovative behaviors of their workforce for survival and competitive advantage. Moreover, this study adds knowledge to work psychology and organizational behavior by explaining the intervening role of creative self-efficacy and moderating role of self-leadership.