Modulation of Host Immune Responses by Fasciola hepatica: Responses of Peripheral Lymphocytes to Mitogens during Liver Fluke Infections of Sheep

Zimmerman, Gary L.; Kerkvliet, Nancy I.; Brauner, Julie A.; Cerro, Jan E.

doi:10.2307/3281356

Cited by 43 publications

(15 citation statements)

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“…This finding is indicative of a persistent immune suppression. All the above findings are in agreement with the findings of other studies of different host species that have included infected rats but that have been performed at earlier stages of infection [19][20][21][22][23][24][25][26]. The reason for this unresponsiveness is not yet known.…”

Section: Discussionsupporting

confidence: 82%

Immune Suppression in Advanced Chronic Fascioliasis: An Experimental Study in a Rat Model

et al. 2007

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Today, fascioliasis is considered to be an important human disease caused by 2 liver fluke species, Fasciola hepatica and Fasciola gigantica (Fasciolidae), infecting the liver of a wide range of mammals [1] that show a marked variability in their immune response against infection [2]. There are several geographic regions that have been reported to be areas of hypoendemicity, mesoendemicity, and hyperendemicity for fascioliasis in

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Section: Discussionsupporting

confidence: 82%

Immune Suppression in Advanced Chronic Fascioliasis: An Experimental Study in a Rat Model

et al. 2007

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“…The decreased responses to mitogens were signi®cant both after primary infection (between 6 and 12 weeks PPI) and after secondary infection (between 2 and 6 weeks PSI). Decreased responses to mitogens have been reported in sheep after primary infections (Zimmerman et al 1983;Chauvin et al 1995), although a short-lived increased response to ConA was observed after secondary infections (Chauvin et al 1995). It has been suggested that parasite products may be responsible for the immunosuppression of PBL responses, and this may explain the failure of the hosts to develop resistance to F. hepatica.…”

Section: Discussionmentioning

confidence: 89%

“…Both humoral and cell-mediated immune responses appear to be important for resistance to F. hepatica, although cellular responses seem to be more relevant. Some mechanisms of immune modulation in F. hepatica infection have also been described in dierent hosts, aecting either antibody activity (Chapman and Mitchell 1982) or lymphocyte response (Zimmerman et al 1983).…”

Section: Introductionmentioning

confidence: 99%

Humoral and cellular immune responses to experimental Fasciola hepatica infections in goats

Martı́nez-Moreno

Martínez-Moreno

Acosta

et al. 1997

Parasitology Research

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Humoral and cellular immune responses to Fasciola hepatica excretory-secretory products (ESPs) in primary and secondary experimental infections in goats were studied. Primary infection induced the development of chronic subclinical fascioliasis that did not affect the establishment of flukes coming from the secondary infection, as the same percentages of recovered flukes were found in both groups. The specific IgG response to F. hepatica ESPs was similar in primary and secondary infections; challenge flukes did not induce any modification in the IgG response. The specific lymphocyte response to F. hepatica ESPs was absent in most of the infected goats, both primarily and secondarily infected. A modulation of the nonspecific cellular responses to mitogens was also observed. All infected goats showed a reduced proliferative response to concanavalin A and phytohemagglutinin. According to our results, humoral and cellular responses to F. hepatica ESPs in goats have no protective effect on the establishment of flukes and the development of disease in either primary or secondary infections.

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“…Food and water were available ad libitum. Sheep and buffaloes were selected for the ability of their lymphocytes to respond to concanavalin A (ConA), as described previously by Zimmerman et al (1983), in order to limit the dispersion of the cellular response.…”

Section: Animalsmentioning

confidence: 99%

Comparison of modulation of sheep, mouse and buffalo lymphocyte responses by Fasciola hepatica and Fasciola gigantica excretory-secretory products

et al. 2005

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In order to explain the difference in susceptibility to Fasciola hepatica and F. gigantica between animal species, the activity of their excretory-secretory products (FhESP and FgESP, respectively) on concanavalin A (ConA)-induced proliferation of different animal species (sheep, mouse and buffalo) lymphocytes was compared. At high doses, FhESP inhibited proliferation of lymphocytes of all the animal species tested, and at low doses they inhibited the proliferation of sheep lymphocytes and increased the proliferation of buffalo and mouse lymphocytes. The effects of FgESP were similar but the intensity of FgESP inhibition was less than FhESP. The immunomodulatory effects of FhESP or FgESP could not alone explain the susceptibility level of hosts to Fasciola spp. The immunomodulatory molecules of FhESP and FgESP and their role in the course of Fasciola spp. infection should be further investigated.

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Modulation of Host Immune Responses by Fasciola hepatica: Responses of Peripheral Lymphocytes to Mitogens during Liver Fluke Infections of Sheep

Cited by 43 publications

References 0 publications

Immune Suppression in Advanced Chronic Fascioliasis: An Experimental Study in a Rat Model

Immune Suppression in Advanced Chronic Fascioliasis: An Experimental Study in a Rat Model

Humoral and cellular immune responses to experimental Fasciola hepatica infections in goats

Comparison of modulation of sheep, mouse and buffalo lymphocyte responses by Fasciola hepatica and Fasciola gigantica excretory-secretory products

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