Modulation of murine experimental asthma by <i>Ascaris suum</i> components

Itami, Denise M; Oshiro, Telma Miyuki; Araújo, Claudia Andréa Alves de; Perini, Adenir; Martins, Mílton A.; Macedo, Mahasti Sahihi de; Macedo-Soares, Maria Fernanda

doi:10.1111/j.1365-2222.2005.02268.x

Cited by 60 publications

(61 citation statements)

References 32 publications

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“…Indeed, a number of parasite-derived products have shown some protective ability in immunopathology models [16,17]. Products of Ancylostoma caninum [43,44], Hymenolepis diminuta [45], Schistosoma mansoni [44] and Trichinella spiralis [46] all contain immunomodulators which can suppress pathology in mouse models of colitis, while somatic constituents of Ascaris suum can inhibit allergic inflammation [47,48], as can secretions of Nippostrongylus brasiliensis [49]. Physiologically, active immunomodulators are most likely to be secreted from live parasites into their host environment [50], and in this report we focus on the H. polygyrus excretory-secretory (HES) products as potential modulators of airway allergy in a mouse model.…”

Section: Introductionmentioning

confidence: 99%

Suppression of type 2 immunity and allergic airway inflammation by secreted products of the helminthHeligmosomoides polygyrus

McSorley

O'Gorman

Blair³

et al. 2012

Eur J Immunol

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Allergic asthma is less prevalent in countries with parasitic helminth infections, and mice infected with parasites such as Heligmosomoides polygyrus are protected from allergic airway inflammation. To establish whether suppression of allergy could be mediated by soluble products of this helminth, we tested H. polygyrus excretory-secretory (HES) material for its ability to impair allergic inflammation. When HES was added to sensitising doses of ovalbumin, the subsequent allergic airway response was suppressed, with ablated cell infiltration, a lower ratio of effector (CD4 + CD25 + Foxp3 − ) to regulatory (CD4 + Foxp3 + ) T (Treg) cells, and reduced Th1, Th2 and Th17 cytokine production. HES exposure reduced IL-5 responses and eosinophilia, abolished IgE production and inhibited the type 2 innate molecules arginase-1 and RELM-α (resistin-like molecule-α). Although HES contains a TGF-β-like activity, similar effects in modulating allergy were not observed when administering mammalian TGF-β alone. HES also protected previously sensitised mice, suppressing recruitment of eosinophils to the airways when given at challenge, but no change in Th or Treg cell populations was apparent. Because heat-treatment of HES did not impair suppression at sensitisation, but compromised its ability to suppress at challenge, we propose that HES contains distinct heat-stable and heat-labile immunomodulatory molecules, which modulate pro-allergic adaptive and innate cell populations.Keywords: Allergy r Eosinophils r IgE r Infection r Macrophages IntroductionAllergic asthma has dramatically increased in prevalence in developing countries, exceeding 5% of the Western European and North American populations [1]. This contrasts with much lower asthma incidence in tropical countries that have significant levels of parasite infections, and these observations have stimulated research into the effects of parasitic organisms on human allergy [2][3][4]. From these studies, it has emerged that allergic diseases are least common in parts of the world with high helminth endemicity, and that within endemic populations the prevalence of atopy is significantly lower in individuals with chronic worm infections [5][6][7][8][9][10].Correspondence: Dr. Rick M. Maizels e-mail: rick.maizels@ed.ac.ukWhile a causal link between human helminth infections and reduced allergy has yet to be proven [2], chemotherapeutic clearance of intestinal helminths can result in accentuated atopic responsiveness [11][12][13] and helminth infection blocks overt allergy in a number of animal models [14][15][16][17]. The degree to which helminths may influence allergy, however, is clearly variable between different parasite species [18], and is probably dependent upon the duration and intensity of infection [2,19], each factors that need to be taken into account in assessing this interaction.The concept that helminths may act in a beneficial way for therapy of immunological disorders is one that has been gaining * These author contributed equally to this work. Eur. J. Immunol. 20...

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Section: Introductionmentioning

confidence: 99%

Suppression of type 2 immunity and allergic airway inflammation by secreted products of the helminthHeligmosomoides polygyrus

McSorley

O'Gorman

Blair³

et al. 2012

Eur J Immunol

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“…According to Miquel et al (2005) both systemic and mucosal A. suum-specific effector mechanisms are strongly stimulated in A. suum single infections and indicate that mucosal IgA may be an important mediator in the expulsion of A. suum. Itami et al (2005) have isolated two distinct components from Ascaris suum adult worms with different effects on the immune system: the allergenic protein of A. suum (APAS-3), which induces IgE antibody production, and suppressive protein of A. suum (PAS-1), which inhibits humoral and cellular immune responses induced by unrelated antigens. A reduced proliferative capacity of murine T-lymphocytes was caused by A. suum extracts (Boitelle et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

The effect of chronic lead acetate trihydrate intoxication in Wistar rats on experimental Ascaris suum infestation and immunity

et al. 2008

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SummarySPF male Wistar rats were exposed for four months to lead acetate trihydrate present in drinking water (100 mg/l) and subsequently infested with 1000 ± 100 infective A. suum eggs. Metabolic activity of phagocytes and proliferative activity of T-lymphocytes were investigated on Day 4 and 8 after A. suum eggs infestation (Day 130 and 134 of lead acetate trihydrate exposition). The results demonstrated that treatment with lead acetate trihydrate led to increased susceptibility to infestation, manifested by increased average number of A. suum larvae in the lungs of exposed rats compared to unexposed ones. Moreover, migration of A. suum larvae on Day 8 was associated with significant increase in index of metabolic activity of phagocytes in unexposed rats in comparison with controls. In contrast, in rats exposed to the lead and infested by A. suum eggs a non-significant increase in the studied immunological parameters was recorded. Significant differences in immunological parameters were observed between unexposed, infested and infested and exposed groups of rats. In the unexposed group of animals Ascaris suum infestation caused a significant increase in the index of metabolic activity of phagocytes and stimulation index of lymphocytes in comparison with lead exposed rats.

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“…Se supone que Ascaris tiene varios componentes inmunomoduladores dada la homología con proteí-nas reconocidas como supresores, pero es poco lo que se ha investigado (76). La mayoría de las molé-culas que se le han purificado han tenido la finalidad de estudiar sus propiedades alergénicas (56,77).…”

Section: Inmunomodulación Producida Por Ascarisunclassified

“…PAS-1 es el componente purificado de este helminto más estudiado como inmunomodulador. Se sabe que inhibe la respuesta inmunológica hacia otros componentes del mismo parásito o de una fuente distinta (76). PAS-1 aumenta el número de Treg y de linfocitos T CD8+ γδTCR+ en ratones, los cuales son fuentes de IL-10 y TGF-β (78).…”

Section: Inmunomodulación Producida Por Ascarisunclassified

Inmunorregulación inducida por helmintos: una actualización

Zakzuk

2016

iatreia

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Las helmintiasis, que han desaparecido o disminuido en las regiones más desarrolladas del mundo, producen cambios notables en el sistema inmunológico, y usualmente, cuando son crónicas o intensas, causan inmunosupresión. Aunque deterioran la salud, también parecen proteger del desarrollo de enfermedades inflamatorias crónicas al proveer estímulos inmunorreguladores. Promueven el desarrollo de linfocitos B o T reguladores que inhiben la proliferación de clones autorreactivos o específicos de alérgeno. Cada vez se conoce más la modulación de la respuesta innata por parásitos; se destaca que además de aumentar en número células claves en la defensa contra estos, también pueden usarlas como blanco de evasión. Algunas poblaciones importantes en la defensa contra bacterias y otros patógenos también responden a los helmintos, pero sufren una programación genética diferente a las formas asociadas a la respuesta tipo 1. Paralelamente a la inmunosupresión, las helmintiasis inducen una respuesta tipo 2. Por esto, es preocupante lo que sucede en algunas poblaciones en donde se controlan parcialmente estas parasitosis y predominan los ciclos de infestación ligera/reinfección. En estos contextos, algunos helmintos, como Ascaris lumbricoides, parecen promover el desarrollo de alergias; esta es la helmintiasis más común en el planeta, pero de la que menos se sabe sobre su capacidad inmunorreguladora. PALABRAS CLAVEAscaris lumbricoides; Helmintiasis; Inmunomodulación; Inmunosupresión SUMMARY Helminth-induced immunoregulation: an updateHelminth infections, which have been reduced or eradicated from most developed countries, produce important changes in the immune system. Especially, when chronic and intense, they 1 MD, PhD. Doctorado en Ciencias Biomédicas.

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Modulation of murine experimental asthma by Ascaris suum components

Cited by 60 publications

References 32 publications

Suppression of type 2 immunity and allergic airway inflammation by secreted products of the helminthHeligmosomoides polygyrus

Suppression of type 2 immunity and allergic airway inflammation by secreted products of the helminthHeligmosomoides polygyrus

The effect of chronic lead acetate trihydrate intoxication in Wistar rats on experimental Ascaris suum infestation and immunity

Inmunorregulación inducida por helmintos: una actualización

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