Molecular and Structural Insights into COVID-19 Pandemic

Kadam, Swapnil; Sukhramani, Geetika S.; Bishnoi, Pratibha; Pable, Anupama A.; Barvkar, Vitthal T.

doi:10.20944/preprints202005.0519.v1

Cited by 8 publications

(6 citation statements)

References 116 publications

(143 reference statements)

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“…This is due to several factors, including the relatively small size of the peptide and differences in MHC processing; they therefore may require carrier proteins or adjuvants [136,137]. Several groups are exploring the use of multi-epitope peptide vaccines against SARS-CoV-2; following bioinformatic and immune-informatic-based predictions of immunogenic epitopes [138][139][140][141], the studies are focusing upon T rather than B cell epitopes. OSE Immunotherapeutics have used a multiepitope peptide approach to induce T cell responses in mice [142].…”

Section: Peptide Vaccinesmentioning

confidence: 99%

Vaccines for COVID-19

Tregoning

Brown

Cheeseman

et al. 2020

Clinical and Experimental Immunology

220

204

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The spread of the virus SARS‐CoV‐2, the cause of COVID‐19 has triggered a tidal wave of vaccine development. In the first 9 months since the virus emerged over 200 vaccines have begun pre‐clinical development, 36 of which have entered clinical trials. This review will cover the platforms under assessment, the immune responses underpinning the vaccines, the results so far and the considerations for the next steps.

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Section: Peptide Vaccinesmentioning

confidence: 99%

Vaccines for COVID-19

Tregoning

Brown

Cheeseman

et al. 2020

Clinical and Experimental Immunology

220

204

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“…Severe acute respiratory syndrome coronavirus 2 is a singleand positive-strand RNA virus with an envelope. As a highly pathogenic coronavirus, it belongs to Betacoronavirus (Kadam et al, 2021). The genome sequence of SARS-CoV-2 (approximately 29.9 kb in size) has approximately 80 and 50% homology to those of SARS-CoV and MERS-CoV, respectively (Arya et al, 2021).…”

Section: Genomic Organization Of Sars-cov-2mentioning

confidence: 99%

Novel receptor, mutation, vaccine, and establishment of coping mode for SARS-CoV-2: current status and future

et al. 2023

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Since the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its resultant pneumonia in December 2019, the cumulative number of infected people worldwide has exceeded 670 million, with over 6.8 million deaths. Despite the marketing of multiple series of vaccines and the implementation of strict prevention and control measures in many countries, the spread and prevalence of SARS-CoV-2 have not been completely and effectively controlled. The latest research shows that in addition to angiotensin converting enzyme II (ACE2), dozens of protein molecules, including AXL, can act as host receptors for SARS-CoV-2 infecting human cells, and virus mutation and immune evasion never seem to stop. To sum up, this review summarizes and organizes the latest relevant literature, comprehensively reviews the genome characteristics of SARS-CoV-2 as well as receptor-based pathogenesis (including ACE2 and other new receptors), mutation and immune evasion, vaccine development and other aspects, and proposes a series of prevention and treatment opinions. It is expected to provide a theoretical basis for an in-depth understanding of the pathogenic mechanism of SARS-CoV-2 along with a research basis and new ideas for the diagnosis and classification, of COVID-19-related disease and for drug and vaccine research and development.

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“…Pandemi Covid disebabkan oleh SARS-CoV-2 (Kadam et al, 2021). Pandemi ini menyebabkan dampak yang besar (Dubey et al, 2020).…”

Section: Pendahuluanunclassified

Pemberdayaan Petugas Kebersihan di Rumah Sakit sebagai Media Transfer Pengetahuan tentang Pencegahan Infeksi kepada Keluarga

Masfiyah

Rahayu²

2022

abdimasku

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Pandemi Covid-19 telah menelan korban yang tidak sedikit. Petugas kebersihan di Rumah Sakit merupakan individu berisiko terpapar karena pekerjaannya. Manusia adalah mahluk sosial, yang selalu berinteraksi terhadap orang lain, terutama keluarganya. Tujuan pengabdian ini untuk menilai apakah ada transfer pengetahuan setelah diadakan pelatihan mengenai pencegahan infeksi pada petugas kebersihan yang bekerja di rumah sakit kepada keluarganya. Pengabdian masyarakat ini dilaksanakan pada September 2020 - Desember 2020. Sampel adalah 25 petugas kebersihan yang bekerja di RS Islam Sultan Agung dan 25 keluarganya. Petugas kebersihan diberi pelatihan tentang pencegahan infeksi meliputi alat pelindung diri, desinfektan, kebersihan lingkungan, etika batuk, dan cuci tangan, kemudian keluarganya dibagikan kuesioner dengan materi yang sama untuk menilai pengetahuan mereka. Hasilnya, sebagian besar responden adalah perempuan (68%) dengan pendidikan terakhir SMA (68%), pekerjaan swasta dan ibu rumah tangga (96%). Skor pengetahuan yang diujikan antara 0-100. Pengetahuan tentang Alat pelindung diri (skor 100), kebersihan lingkungan (skor 70-100), desinfektan (skor 84-100), etika batuk (skor 76-100), dan cuci tangan (skor 80-100). Sebanyak 72% mendapat informasi pengetahuan dari keluarganya yang bekerja sebagai petugas kebersihan di rumah sakit Islam Sultan Agung. Dapat disimpulkan bahwa terdapat transfer pengetahuan antara petugas kebersihan kepada keluarganya tentang pencegahan infeksi.The Covid-19 pandemic has claimed many victims. Cleaning workers in hospitals are individuals who are at risk of exposure due to their work. Humans are social creatures, who always interact with other people, especially their families. The purpose of this service is to assess whether there is a transfer of knowledge after training on infection prevention for janitors who work in hospitals to their families. This community service was carried out in September 2020 - December 2020. The sample was 25 cleaners who worked at Sultan Agung Islamic Hospital and 25 of their families. The cleaning staff were given training on infection prevention including personal protective equipment, disinfectants, environmental hygiene, cough etiquette, and hand washing, then their families were distributed questionnaires with the same material to assess their knowledge. As a result, most of the respondents were women (68%) with a high school education (68%), private jobs and housewives (96%). The knowledge score tested is between 0-100. Knowledge of personal protective equipment (score 100), environmental hygiene (score 70-100), disinfectants (score 84-100), cough etiquette (score 76-100), and hand washing (score 80-100). As many as 72% received information about knowledge from their families who work as janitors at Sultan Agung Islamic Hospital. It can be concluded that there is a transfer of knowledge between janitors and their families about infection prevention.

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Molecular and Structural Insights into COVID-19 Pandemic

Cited by 8 publications

References 116 publications

Vaccines for COVID-19

Vaccines for COVID-19

Novel receptor, mutation, vaccine, and establishment of coping mode for SARS-CoV-2: current status and future

Pemberdayaan Petugas Kebersihan di Rumah Sakit sebagai Media Transfer Pengetahuan tentang Pencegahan Infeksi kepada Keluarga

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