Molecular recognition of procainamide-imprinted polymer

Chen, Wen; Liu, Feng; Xu, Yitie; Li, Ke An; Tong, Shenyang

doi:10.1016/s0003-2670(00)01371-4

Cited by 19 publications

(8 citation statements)

References 20 publications

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“…628,865,910 However, MIPs can show effective recognition in solvents other than that used as porogen, including aqueous buffers; 911 in this case a switch in recognition mechanism from H-bonding to hydrophobic recognition can be demonstrated by a loss of recognition in intermediate aqueous-organic mixtures. 891,912 The effect of organic modifiers, such as acetic acid, on binding to MIPs in HPLC has been studied; 913 they function by reducing non-specific interactions with both MIP and control. The use of surfactants as modifiers in aqueous-based recognition studies and in SPE and chromatography has also been reported.…”

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confidence: 99%

Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003

Andersson²,

et al. 2006

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Over 1450 references to original papers, reviews and monographs have herein been collected to document the development of molecular imprinting science and technology from the serendipitous discovery of Polyakov in 1931 to recent attempts to implement and understand the principles underlying the technique and its use in a range of application areas. In the presentation of the assembled references, a section presenting reviews and monographs covering the area is followed by papers dealing with fundamental aspects of molecular imprinting and the development of novel polymer formats. Thereafter, literature describing attempts to apply these polymeric materials to a range of application areas is presented.

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confidence: 99%

Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003

Andersson²,

et al. 2006

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“…The growth of a threedimensional polymeric structure around the template produces binding sites with proper shape and charge distribution has greatly effected molecular recognition. It has been demonstrated that a significant contribution in the interaction between template molecules and functional groups on the surface of the binding sites is due to the hydrogen bond [13 -15] and ionexchange phenomena, [16] and the environment around the binding site, [17] For example, most MIPs are prepared by non-covalent imprinting and the common systems are based on commodity methacrylic monomers, such as methacrylic acid because its carboxyl group is the most common hydrogen bonding and acidic functional group in molecular imprinting, cross-linked with ethyleneglycol dimethacrylate. [18,19] In this work, the monolithic MIP column was prepared by a simple, one step, in-situ, free-radical polymerization "molding" process directly within the chromatographic column, without the tedious procedures of grinding, sieving, and column packing.…”

Section: Special Selectivity Of Molecularly Imprinted Monolithic Statmentioning

confidence: 99%

Special Selectivity of Molecularly Imprinted Monolithic Stationary Phase

Yan

Jin

Row

2005

Journal of Liquid Chromatography & Related Technologies

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A monolithic, molecularly imprinted column was prepared by an in situ therm-initiated copolymerization process; the essential conditions of forming a noncovalent molecular imprinting stationary phase are discussed and illustrated with caffeine and theophylline as examples from the angle of molecular construction, and examined by experiments. The results showed that the theophylline-imprinted monolithic column has high selectivity to theophylline; baseline separation of caffeine and theophylline was achieved. However, only weak specific selectivity to the template molecule was observed for the caffeine imprinted monolithic column.

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“…In general, most of the research on MIP have used very high portion of crosslinking monomer to maintain the three-dimensional shapes for the template. [10][11][12][13][14] As a consequence of the use of high concentration of crosslinking monomer, an extremely rigid polymer were obtained. The rigidity makes MIP very difficult to remove the template.…”

Section: Introductionmentioning

confidence: 99%

Separation of hydroxybenzoic acid isomers using the molecular imprinting technique

Park¹,

Yoon²,

Lee³

et al. 2007

J of Applied Polymer Sci

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Molecular imprinting polymers (MIPs) for salicylic acid (SA), 3-hydroxybenzoic acid (3HBA), and 4-hydroxybenzoic acid (4HBA) were synthesized using styrene and 4-vinylpyridine (4-VPy) as functional monomer and divinylbenzene (DVB) as crosslinker. The adsorption characteristics of hydroxybenzoic acid (HBA) isomers on each MIP were investigated. The materials used for the polymerization of each 3HBA and 4HBA-MIPs were adsorbed relatively well. This verifies that the MIPs that can adsorb template selectively were synthesized. However, SA-MIP had no molecular imprinting effect. SA has intramolecular hydrogen bond and it is difficult to adsorb on recognition site of SA-MIP, because its structure differs from that of recognition site of SA-MIP. It indicates that SA-MIP had no recognition effect. 1,2,3,4-Tetrahydro-1-naphthol (THN)-MIP was synthesized, which is similar to SA with intramolecular hydrogen bond. SA was separated selectively using THN-MIP.

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Molecular recognition of procainamide-imprinted polymer

Cited by 19 publications

References 20 publications

Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003

Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003

Special Selectivity of Molecularly Imprinted Monolithic Stationary Phase

Separation of hydroxybenzoic acid isomers using the molecular imprinting technique

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