Molecularly imprinted thin film surfaces in sensing: Chances and challenges

Unger, Christine; Lieberzeit, Peter A.

doi:10.1016/j.reactfunctpolym.2021.104855

Cited by 54 publications

(25 citation statements)

References 32 publications

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“…In order to confine the templated sites exclusively to the polymer surface, several techniques have been exploited, such as soft lithography [ 6 , 22 , 23 ], micro-contact imprinting [ 24 – 26 ], and sacrificial template support methods [ 27 , 28 ]. In this respect, in the field of electrochemical sensing, one alternative is the deposition of MIP layers directly on the electrode surface, which represents a suitable approach for achieving ultrathin polymers only partially embedding the target protein.…”

Section: Approaches For Imprinting Of Macromolecules In Electrochemic...mentioning

confidence: 99%

“…One of the most fascinating aspects of electrochemical polymerization, which justifies its large use in sensing schemes, is the possibility for easy integration of the MIP layer with the transducer surface, even in the case of substrates with unconventional geometry [ 114 , 115 ], affording a low-cost and easy-to-use setup. The resulting MIP thickness, which plays a vital role in both template removal and rebinding steps [ 24 , 35 , 116 ], can be easily controlled by simply monitoring the amount of circulated charge during the electropolymerization process and, related to this, the scan rate, specifically when electropolymerization is carried out by cyclic voltammetry [ 14 , 117 ]. Other properties of the resulting MIP possibly critically influencing the imprinting process can be tuned by varying different electropolymerization experimental conditions, as in the case of polymer porosity, which can be modified by the supporting electrolyte properties [ 118 ].…”

Section: Mip Format Suitable For the Electrochemical Sensing Of Macro...mentioning

confidence: 99%

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Electrochemical sensing of macromolecules based on molecularly imprinted polymers: challenges, successful strategies, and opportunities

2022

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Looking at the literature focused on molecularly imprinted polymers (MIPs) for protein, it soon becomes apparent that a remarkable increase in scientific interest and exploration of new applications has been recorded in the last several years, from 42 documents in 2011 to 128 just 10 years later, in 2021 (Scopus, December 2021). Such a rapid threefold increase in the number of works in this field is evidence that the imprinting of macromolecules no longer represents a distant dream of optimistic imprinters, as it was perceived until only a few years ago, but is rapidly becoming an ever more promising and reliable technology, due to the significant achievements in the field. The present critical review aims to summarize some of them, evidencing the aspects that have contributed to the success of the most widely used strategies in the field. At the same time, limitations and drawbacks of less frequently used approaches are critically discussed. Particular focus is given to the use of a MIP for protein in the assembly of electrochemical sensors. Sensor design indeed represents one of the most active application fields of imprinting technology, with electrochemical MIP sensors providing the broadest spectrum of protein analytes among the different sensor configurations. Graphical abstract

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Section: Approaches For Imprinting Of Macromolecules In Electrochemic...mentioning

confidence: 99%

Section: Mip Format Suitable For the Electrochemical Sensing Of Macro...mentioning

confidence: 99%

Electrochemical sensing of macromolecules based on molecularly imprinted polymers: challenges, successful strategies, and opportunities

2022

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“…Molecularly imprinted polymers (MIPs) constitute a possible strategy to obtain the artificial receptors needed for that purpose [20,21]. MIPs rely on-usually-highly cross-linked polymers that are able to bind their target species based on a key-lock mechanism [22,23].…”

Section: Introductionmentioning

confidence: 99%

Development of a MIP-Based QCM Sensor for Selective Detection of Penicillins in Aqueous Media

et al. 2021

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Pharmaceuticals wastes have been recognized as emerging pollutants to the environment. Among those, antibiotics in the aquatic environment are one of the major sources of concern, as chronic, low-dose exposure can lead to antibiotic resistance. Herein, we report on molecularly imprinted polymers (MIP) to recognize penicillin V potassium salt (PenV-K), penicillin G potassium salt (PenG-K), and amoxicillin sodium salt (Amo-Na), which belong to the most widespread group of antibiotics worldwide. Characterization and optimization led to two MIPs comprising methacrylic acid as the monomer and roughly 55% ethylene glycol dimethacrylate as the crosslinker. The obtained layers led to sensitive, selective, repeatable, and reusable sensor responses on quartz crystal microbalances (QCM). The LoD for PenV-K, PenG-K, and Amo-Na sensors are 0.25 mM, 0.30 mM, and 0.28 mM, respectively; imprinting factors reach at least around three. Furthermore, the sensors displayed relative selectivity factors of up to 50% among the three penicillins, which is appreciable given their structural similarity.

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“…Furthermore, the production is versatile and can be adjusted easily towards the respective target analyte. There are many examples for MIPs used for sensing [ 19 , 20 , 21 ]. For actual commercialization, it is important to access the ability of the MIPs to perform in real samples.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Sensors to Detect Bioanalytes in Real-Life Samples Using Molecularly Imprinted Polymers: A Review

Bräuer

Unger

Werner

et al. 2021

Sensors

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Molecularly imprinted polymers (MIPs) come with the promise to be highly versatile, useful artificial receptors for sensing a wide variety of analytes. Despite a very large body of literature on imprinting, the number of papers addressing real-life biological samples and analytes is somewhat limited. Furthermore, the topic of MIP-based sensor design is still, rather, in the research stage and lacks wide-spread commercialization. This review summarizes recent advances of MIP-based sensors targeting biological species. It covers systems that are potentially interesting in medical applications/diagnostics, in detecting illicit substances, environmental analysis, and in the quality control of food. The main emphasis is placed on work that demonstrates application in real-life matrices, including those that are diluted in a reasonable manner. Hence, it does not restrict itself to the transducer type, but focusses on both materials and analytical tasks.

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Molecularly imprinted thin film surfaces in sensing: Chances and challenges

Cited by 54 publications

References 32 publications

Electrochemical sensing of macromolecules based on molecularly imprinted polymers: challenges, successful strategies, and opportunities

Electrochemical sensing of macromolecules based on molecularly imprinted polymers: challenges, successful strategies, and opportunities

Development of a MIP-Based QCM Sensor for Selective Detection of Penicillins in Aqueous Media

Biomimetic Sensors to Detect Bioanalytes in Real-Life Samples Using Molecularly Imprinted Polymers: A Review

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