Momordica charantia Constituents and Antidiabetic Screening of the Isolated Major Compounds.

Harinantenaina, Liva; Tanaka, Michi; Takaoka, Shigeru; Oda, Munehiro; Mogami, Orie; Uchida, Masayuki; Asakawa, Yoshinori

doi:10.1002/chin.200652188

Cited by 27 publications

(42 citation statements)

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“…Bitterness of fruit is controlled by a single gene, with more bitterness dominant to less (Suribabu et al, 1986). Saponins, momordicosides K and L, as well as momordicines I and II cause the bitter taste (Harinantenaina et al, 2006).…”

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confidence: 99%

Diversity Among a Wide Asian Collection of Bitter Gourd Landraces and their Genetic Relationships with Commercial Hybrid Cultivars

Dhillon¹,

Sanguansil²,

Schafleitner³

et al. 2016

J. Amer. Soc. Hort. Sci.

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We report here the genetic characterization of bitter gourd (Momordica charantia) based on polymorphisms of 50 simple sequence repeat (SSR) loci in 114 accessions that included landraces, breeding lines, and commercial open-pollinated and F1 hybrid cultivars widely grown in Asia. Neighbor-joining tree analysis revealed a high level of genetic variability in the collection. The 114 accessions formed three subpopulations represented by five clusters. Distribution of accessions across the five clusters reflected their geographic origin to a large extent. South Asian accessions originating from India, Bangladesh, and Pakistan were more closely related to each other than to any other geographical group. Likewise, southeast Asian accessions that originated from Cambodia, Vietnam, Indonesia, and Philippines were grouped together. Accessions that originated from Taiwan were genetically distinct and grouped separately. A landrace from Laos was genetically close to the accessions from Thailand and genetically distinct from the rest of the accessions. White-fruited genotypes were genetically distinct from green- and dark green–fruited genotypes. Low- and medium-bitter accessions were more similar to each other than to the high-bitter genotypes. Accessions with cylindrical fruit were genetically distinct from those with spindle or elongated fruit. Commercial cultivars in each cluster were closely related, which indicated a narrowing of the bitter gourd genetic base in Asia in response to market demands for uniformity and yield. Use of diverse germplasm resources in bitter gourd breeding will help in sustainable breeding and production.

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confidence: 99%

Diversity Among a Wide Asian Collection of Bitter Gourd Landraces and their Genetic Relationships with Commercial Hybrid Cultivars

Dhillon¹,

Sanguansil²,

Schafleitner³

et al. 2016

J. Amer. Soc. Hort. Sci.

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“…Studies have tested new drugs for the treatment of skin wounds in patients with DM in an attempt to minimize inflammation and to accelerate the repair process by increasing the production of fibroblasts and collagen fibers, factors that are important for wound healing 9 . Medicinal plants such as Strychnos pseudoquina…”

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confidence: 99%

“…and Momordica charantia have been used for the treatment of DM as coadjuvants in the anti-inflammatory process 9,10 .…”

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confidence: 99%

Cenostigma macrophyllum Tul. on the healing of skin wounds in rats with Diabetes mellitus

et al. 2013

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“…The phytochemical studies reported earlier indicate that alkaloids, steroids and steroidal lactones isolated from other plant sources are responsible for their hypoglycemic activity (Sofowora 1982;Adebajo et al 2006;Hrinantenaina et al 2006;Pries et al 2006;Veiga et al 2006). A number of steroidal lactones have also been reported from W. coagulans (Ramaiah et al 1984;Choudhary et al 1995;Rahman et al 1998Rahman et al , 1999Nur-e-Alam et al 2003).…”

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confidence: 97%

Hypoglycemic and Antidiabetic Effects of Withania Coagulans Fruit Ethanolic Extract in Normal and Streptozotocin-Induced Diabetic Rats

Jaiswal

Kumar

Watal³

2010

Journal of Food Biochemistry

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The study deals with the effect of ethanolic extract of Withania coagulans fruits on normal and streptozotocin‐induced diabetic models. The maximum reduction of 39.2% in fasting blood glucose at 4 h and 39.9% during oral glucose tolerance test at 2 h was observed with the dose of 750 mg/kg in normal rats, whereas the reduction observed was 47.1 and 42.7% in blood glucose levels of sub‐ and mild diabetic rats, respectively, at 2 h during oral glucose tolerance test with the same dose. Long‐term study of severely diabetic rats showed reduction of 48.5 and 52.6% in fasting blood glucose and postprandial glucose levels, respectively, after 30 days of treatment. In addition 75% decrease in urine sugar and 13.08% increase in body weight of treated group was found at the end of the experiment. Trace elements present in the text were identified through laser‐induced breakdown spectroscopy. PRACTICAL APPLICATIONS The Withania coagulans has been shown to possess varied medicinal properties. The aqueous extract of the fruits has been shown to exert hepatoprotective, antiinflammatory and antidiabetic activity. Recently, it has been reported by our research group that the aqueous extract of W. coagulans has hypoglycemic potential. The present communication is an endeavor in the direction of evaluating the in vivo hypoglycemic as well as antidiabetic effect from ethanolic extract W. coagulans fruits in streptozotocin‐induced diabetic rats so that it can be used as a value added agent for managing diabetes.

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Momordica charantia Constituents and Antidiabetic Screening of the Isolated Major Compounds.

Cited by 27 publications

References 1 publication

Diversity Among a Wide Asian Collection of Bitter Gourd Landraces and their Genetic Relationships with Commercial Hybrid Cultivars

Diversity Among a Wide Asian Collection of Bitter Gourd Landraces and their Genetic Relationships with Commercial Hybrid Cultivars

Cenostigma macrophyllum Tul. on the healing of skin wounds in rats with Diabetes mellitus

Hypoglycemic and Antidiabetic Effects of Withania Coagulans Fruit Ethanolic Extract in Normal and Streptozotocin-Induced Diabetic Rats

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