Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer

Chen, Xiao; Hu, Zeping; Yang, Xiao; Huang, Min; Gao, Yihuai; Tang, Wenbo; Chan, Sui Yung; Dai, Xihu; Ye, Jinxian; Ho, P.; Duan, Wei; Yang, Hongyuan; Zhu, Yi‐Zhun; Zhou, Shu Feng

doi:10.1016/j.intimp.2005.08.026

Cited by 116 publications

(62 citation statements)

References 34 publications

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“…A proprietary extract (D-Fraction) of Grifola frondosa, also called Maitake, caused small changes in CD4þ and CD8þ counts while increasing NK cell activity in all 10 advanced cancer patients [96]. Oral polysaccharides from Ganoderma lucidum, also known as Ling zhi or Reishi, when given in a dose of 5.4 g per day for 12 weeks, improved the mitogenic reactivity to phytohemagglutinin, increased CD3, CD4, CD8, and CD56 lymphocyte counts, and increased NK activity, while elevating plasma concentrations of interleukin (IL)-2, IL-6, and gamma interferon, and decreasing tumor necrosis factor alpha and IL-3 in 46 subjects with a variety of advanced stage cancers [97,98]. However, a study in 30 advanced lung cancer patients showed marked variability in immune response to the Ganoderma extract, suggesting that certain subgroups of patients may be more responsive than others [99].…”

Section: Immune Modulationmentioning

confidence: 99%

Dietary Supplement Use in Cancer Care: Help or Harm

Hardy

2008

Hematology/Oncology Clinics of North America

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Section: Immune Modulationmentioning

confidence: 99%

Dietary Supplement Use in Cancer Care: Help or Harm

Hardy

2008

Hematology/Oncology Clinics of North America

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“…(3) Usually, immunomodulators are used clinically in patients with impaired immunity to cope with cases of malignancy, HIV/ AIDS, malnutrition and allergies. (4) A …”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory Effect of Momordica charantia L. Fruit Ethanol Extract on Phagocytic Activity and Capacity of Mice Peritoneal Macrophages

et al. 2018

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B ACKGROUND:The purpose of this research is to understand the secondary metabolites of Momordica charantia L. extract, as well as to disclose the potential of M. charantia extract in the phagocytic activity and capacity of peritoneum macrophages. METHODS:Examination of immunomodulatory effect was done by giving M. charantia ethanol extract on 5 treatment groups, given intra-peritoneally to mice daily. Echinacea extract as positive control and double distilled water as negative control were also given. On the 8 th day, mice were infected with Staphylococcus epidermidis. After 30 minutes, peritoneum fluid was obtained to observe the activity and capacity of macrophage cells. RESULTS:The results showed significant phagocytic activity (p<0.05) at a concentration of 1,200 ppm compare to the other groups. Meanwhile the macrophage cell capacity was found statistically insignificant (p>0.05). The highest phagocytic activity was the group treated with 1,200 ppm (62%), significantly higher than other groups. CONCLUSION:The secondary metabolite content of M. charantia is alkaloids, flavonoids, tannins, saponins, and triterpenoids. The 1,200 ppm M. charantia ethanol extract is potential in inducing phagocytic activity and capacity. These results indicate that the M. charantia can be suggested as a natural immunomodulator. KEywORDS

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“…8 Furthermore, THM have been shown to possess immunopharmaceutical effects by modulating lymphocyte functions and immune effector cells. 9 Some traditional herbal components have also been shown to have antitumor effects by improving immune functions in vitro and in vivo. 10,11 572881I CTXXX10.1177/1534735415572881Integrative Cancer TherapiesKim et al Recently, much research is being conducted to determine the effect of THM on cancer, and several articles have already been published demonstrating the effects of THM on a variety of cancers.…”

Section: Introductionmentioning

confidence: 99%

Traditional Herbal Medicine as Adjunctive Therapy for Nasopharyngeal Cancer

Kim

Lee

et al. 2015

Integr Cancer Ther

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The effectiveness of traditional herbal medicine (THM) as treatment for nasopharyngeal cancer (NPC) has not been clearly demonstrated. The aim of this study is to assess the effectiveness of THM as adjunctive therapies for NPC using the results of randomized controlled trials (RCTs). Five electronic databases, including English and Chinese databases, were systematically searched up to February 2014. All RCTs involving traditional herbal medicine in combination with conventional cancer therapy for NPC were included. Twenty-two RCTs involving 2,298 NPC patients were systematically reviewed. Of these 22 studies, 15 on 1482 patients reported a significant increase in the number surviving patients with survivals of more than 1, 3, or 5 years. Seven studies on 595 patients reported a significant increase in immediate tumor response, and three studies on 505 patients reported a significant decrease in distant metastasis. This meta-analysis of 22 studies suggests that THM combined with conventional therapy can provide an effective adjunctive therapy for NPC. More research and well-designed, rigorous, large clinical trials are required to address these issues

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Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer

Cited by 116 publications

References 34 publications

Dietary Supplement Use in Cancer Care: Help or Harm

Dietary Supplement Use in Cancer Care: Help or Harm

Immunomodulatory Effect of Momordica charantia L. Fruit Ethanol Extract on Phagocytic Activity and Capacity of Mice Peritoneal Macrophages

Traditional Herbal Medicine as Adjunctive Therapy for Nasopharyngeal Cancer

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