Mono‐ and Divalent Electrolyte Patterns, pCO<sub>2</sub> and pH in Relation to Flow Rate in Normal Human Parotid Saliva*

Kreußer, W.; Heidland, A.; Hennemann, H; Wigand, M. E.; Knauf, H.

doi:10.1111/j.1365-2362.1972.tb00668.x

Cited by 61 publications

(25 citation statements)

References 26 publications

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“…This is also in contrast with the results presented here. The present study confirms the finding of Kreusser et al [1972] showing a pH in crease with flow rate. Since the ionized cal cium concentration decreases slightly with increasing salivary pH value [Lagerlof, 1980], a decrease in the ratio ionized cal cium/total calcium could be expected and was subsequently found in our study.…”

Section: Discussionsupporting

confidence: 81%

The Effect of Flow Rate on the Ionized Calcium Concentration of Human Parotid Saliva

Lagerlöf

Ekstrand²

1982

Caries Res

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The ionized calcium concentration of parotid saliva collected at six preselected flow rates ranging from 0.13 to 2.00 ml/min was determined using an ionselective electrode. Total calcium, protein, pH value and ionic strength were also measured. Three experiments were carried out on each of 5 subjects. Increases of total calcium from 0.70 to 1.17mmol/l and ionized calcium from 0.31 to 0.50 mmol/l were noted. Concentrations of ionized calcium and total calcium were significantly correlated (r = 0.83), and the ratio ionized calcium/total calcium decreased from 0.48 to 0.43 in the flow rate range 0.13–2.00 ml/min. This ratio was affected by the pH value and found to be independent of the flow rate at pH 5.7. The protein concentration, which increased with flow rate, was significantly correlated to the calcium concentration.

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Section: Discussionsupporting

confidence: 81%

The Effect of Flow Rate on the Ionized Calcium Concentration of Human Parotid Saliva

Lagerlöf

Ekstrand²

1982

Caries Res

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“…It is well known that the protein concentration increases at most twofold as parotid flow increases from the resting state to 1 ml/min (6). In contrast, sodium levels can increase over 30-fold, from a resting 2 to 60 meq/liter or more (6,14). The increase in sodium levels in stimulated secretion is due to the reduced reabsorption of this ion in the ductal system under these conditions.…”

Section: Fig 4 Candidacidal Activities Of Undialyzed Parotid Secretmentioning

confidence: 94%

Dialysis Unmasks the Fungicidal Properties of Glandular Salivary Secretions

et al. 2004

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Several salivary proteins exhibit fungicidal activity against the opportunistic oral pathogen Candida albicans when they are tested as pure proteins in vitro. However, salivary secretions that are examined by the same assays either lack or exhibit very low candidacidal activity. Since ionic strength is known to have an inhibitory effect on the fungicidal activities of some proteins, parotid secretion was subjected to dialysis with membranes having molecular weight cutoffs (MWCOs) of 500, 1,000, 10,000, and 25,000. Dialysis with membranes with MWCOs of >1,000 promoted fungicidal activity of parotid secretion, and this activity was dose dependent. The addition of sodium chloride to dialyzed, fungicidal parotid secretion abolished this activity, indicating that the fungicidal component was salt sensitive. Similar results were obtained with submandibular and sublingual secretions. Polyacrylamide gel electrophoresis under native and denaturing conditions was used to analyze the composition of the dialysate. Unexpectedly, proteins with MWs much lower than the nominal MWCOs of the membranes were not lost during dialysis. Among the retained proteins, the two fractions with MWs of approximately 17,000 and 4,000 exhibited fungicidal activity. These results are consistent with the presence of lysozyme and histatins, respectively, which may represent the major candidacidal capacity of dialyzed parotid secretion.

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“…With respect to phosphate concentration, the group presenting the highest rate was that of patients with SSs. However, we note that the levels increase in SSp, which is discordant since it has been shown that phosphate concentration varies inversely with salivary flow rate (16,17). In all groups, differences were statistically significant in relation to controls.…”

Section: Discussionmentioning

confidence: 57%

Assessing the determination of salivary electrolytes and anti-Ro and anti-La antibodies for the diagnosis of Sjogren s syndrome (SS)

Busamia¹,

Gonzales-Moles²,

Mazzeo³

et al. 2010

Med Oral

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The aim of this study was to assess changes in salivary electrolyte flow and composition and the presence of anti-Ro/SSA and anti-La/SSB serum and saliva antibodies and their implications for the non-invasive diagnosis of SS. Study design: 73 patients were studied, divided into the following experimental groups: primary Sjögren syndrome (SSp) (n=15), secondary SS (SSs) (n=17), dry mouth, dry eye without Sjögren's syndrome (BO) (n=20) and healthy controls (C) (n=21). We conducted a baseline assessment of salivary flow and saliva sampling for the measurement of sodium, chlorine, potassium, calcium and phosphate electrolytes, and the determination of antiRo/SSA and La/SSB antibodies; a serum sampling was made to assess antibody positivity. Results: Salivary flow in SSp, SSs and BO was significantly lower (p<0.001) relative to C. The salivary composition of SS showed an increase of inorganic components. Anti-Ro/SSA and anti-La/SSB antibodies occurred more frequently in serum and saliva in SS patients compared with BO and C, with higher frequency of positivity in serum compared with saliva. Conclusion: Our results suggest new tools that could aid the non-traumatic diagnosis of the origin of hyposalivation.

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Mono‐ and Divalent Electrolyte Patterns, pCO₂ and pH in Relation to Flow Rate in Normal Human Parotid Saliva*

Cited by 61 publications

References 26 publications

The Effect of Flow Rate on the Ionized Calcium Concentration of Human Parotid Saliva

The Effect of Flow Rate on the Ionized Calcium Concentration of Human Parotid Saliva

Dialysis Unmasks the Fungicidal Properties of Glandular Salivary Secretions

Assessing the determination of salivary electrolytes and anti-Ro and anti-La antibodies for the diagnosis of Sjogren s syndrome (SS)

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Mono‐ and Divalent Electrolyte Patterns, pCO2 and pH in Relation to Flow Rate in Normal Human Parotid Saliva*

Cited by 61 publications

References 26 publications

The Effect of Flow Rate on the Ionized Calcium Concentration of Human Parotid Saliva

The Effect of Flow Rate on the Ionized Calcium Concentration of Human Parotid Saliva

Dialysis Unmasks the Fungicidal Properties of Glandular Salivary Secretions

Assessing the determination of salivary electrolytes and anti-Ro and anti-La antibodies for the diagnosis of Sjogren s syndrome (SS)

Contact Info

Product

Resources

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Mono‐ and Divalent Electrolyte Patterns, pCO₂ and pH in Relation to Flow Rate in Normal Human Parotid Saliva*