Monoterpene phenolic compound thymol promotes browning of 3T3-L1 adipocytes

Choi, Jae Heon; Kim, Sang Woo; Yu, Rina; Yun, Jong Won

doi:10.1007/s00394-016-1273-2

Cited by 67 publications

(42 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…confirmed that phytol (acyclic diterpene) increases the number of adipocytes and prevent obesity. Moreover , many investigators suggested that a dietary monoterpene phenolic compound of thymol and monoterpene of limonene plays a role in the browning of white adipocytes, augmentation of lipolysis, fat oxidation, and thermogenesis …”

Section: Discussionmentioning

confidence: 99%

Amelioration of experimental metabolic syndrome induced in rats by orlistat and Corchorus olitorius leaf extract; role of adipo/cytokines

Gomaa

Elsers

Al-Zokeim

et al. 2019

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

Objectives To determine the efficacy of Corchorus olitorius (C. olitorius) leaf extract in the prevention of metabolic syndrome induced in rats by high‐fat diet (HFD) and compare it with that of orlistat. Methods Phytochemical analysis was performed. Effect of orlistat and C. olitorius extract on lipase activity and acute food intake were investigated. Body weight, biochemical parameters and histopathological examination were demonstrated. Key findings Corchorus olitorius extract inhibited the pancreatic lipase activity, but orlistat was more potent. Cumulative food intake has not changed by the tested agents. In obese rats, C. olitorius or orlistat significantly decreased weight gain and visceral white adipose tissue. They exhibited a significant reduction in serum glucose, total cholesterol, triglycerides, low density lipoprotein cholesterol, free fatty acids, IL‐1β, tumour necrosis factor‐α (TNF‐α), insulin and leptin levels of obese rat groups while high density lipoprotein cholesterol and adiponectin levels were significantly increased by them. Histopathological examination of the liver revealed that C. olitorius was more effective than orlistat in the alleviating of steatosis and adipocyte hypertrophy shown in obese control rats. Conclusions Corchorus olitorius is effective as orlistat in preventing obesity, hyperlipidaemia, steatosis and insulin resistance. These actions may be mediated by inhibiting of lipase activity, TNF‐α, IL‐1β and leptin resistance along with increasing of adiponectin.

show abstract

Section: Discussionmentioning

confidence: 99%

Amelioration of experimental metabolic syndrome induced in rats by orlistat and Corchorus olitorius leaf extract; role of adipo/cytokines

Gomaa

Elsers

Al-Zokeim

et al. 2019

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

“…Findings have been consistent with each other, indicating that THY supplementation leads to a big increase in antioxidant enzyme activity involving glutathione peroxidase and superoxide dismutase and a decrease in malondialdehyde levels, associated with a greater concentration of PUFA precursors such as linoleic acid and α ‐linolenic acid as well as LC derivatives such as arachidonic acid and docosahexaenoic acid, as observed herein. Additionally, in vitro and in vivo studies have demonstrated that THY as well as EOs with THY supplementation may alter several lipid metabolic pathways, including bile acid, cholesterol synthesis and fatty acid metabolism, indicating that THY plays multiple modulatory roles in lipid metabolism . One of the mechanisms by which supplementation with THY or EOs containing THY would reflect an increase in the antioxidant capacity/status of supplemented females is based on its inhibitory effect on lipogenesis and its hypolipidemic actions .…”

Section: Discussionmentioning

confidence: 99%

Thymol feed supplementation in quail alters the percentages of nutritionally relevant egg yolk fatty acids: effects throughout incubation

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Thymol promotes the expressions of brown fat-specific markers including PPARγ via activation of AMPK signalling [37]. Pretreatment with AMPK agonist AICAR significantly prevented the increased TLR4 protein expressions (Fig.…”

Section: Resultsmentioning

confidence: 99%

Interactions of TLR4 and PPARγ, Dependent on AMPK Signalling Pathway Contribute to Anti-Inflammatory Effects of Vaccariae Hypaphorine in Endothelial Cells

Sun¹,

Zhu²,

Lin³

et al. 2017

Cell Physiol Biochem

View full text Add to dashboard Cite

Background /Aims: Accumulating evidence indicates that endothelial inflammation is one of the critical determinants in pathogenesis of atherosclerotic cardiovascular disease. Our previous studies had demonstrated that Vaccariae prevented high glucose or oxidative stress-triggered endothelial dysfunction in vitro. Very little is known about the potential effects of hypaphorine from Vaccariae seed on inflammatory response in endothelial cells. Methods: In the present study, we evaluated the anti-inflammatory effects of Vaccariae hypaphorine (VH) on lipopolysaccharide (LPS)-challenged endothelial EA.hy926 cells. The inflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), monocyte chemoattractant protein 1 (MCP-1) and vascular cellular adhesion molecule-1 (VCAM-1) were measured by real-time PCR (RT-PCR). The expressions of adenosine monophosphate-activated protein kinase (AMPK), acetyl-CoA carboxylase (ACC), toll-like receptor 4 (TLR4), peroxisome proliferator-activated receptor γ (PPARγ) were detected by Western blotting or immunofluorescence. Results: We showed that LPS stimulated the expressions of TNF-α, IL-1β, MCP-1, VCAM-1 and TLR4, but attenuated the phosphorylation of AMPK and ACC as well as PPARγ protein levels, which were reversed by VH pretreatment. Moreover, we observed that LPS-upregulated TLR4 protein expressions were inhibited by PPARγ agonist pioglitazone, and the downregulated PPARγ expressions in response to LPS were partially restored by knockdown of TLR4. The negative regulation loop between TLR4 and PPARγ response to LPS was modulated by AMPK agonist AICAR (5-Aminoimidazole-4-carboxamide riboside or acadesine) or A769662. Conclusions: Taken together, our results suggested that VH ameliorated LPS-induced inflammatory cytokines production in endothelial cells via inhibition of TLR4 and activation of PPARγ, dependent on AMPK signalling pathway.

show abstract

Monoterpene phenolic compound thymol promotes browning of 3T3-L1 adipocytes

Cited by 67 publications

References 43 publications

Amelioration of experimental metabolic syndrome induced in rats by orlistat and Corchorus olitorius leaf extract; role of adipo/cytokines

Amelioration of experimental metabolic syndrome induced in rats by orlistat and Corchorus olitorius leaf extract; role of adipo/cytokines

Thymol feed supplementation in quail alters the percentages of nutritionally relevant egg yolk fatty acids: effects throughout incubation

Interactions of TLR4 and PPARγ, Dependent on AMPK Signalling Pathway Contribute to Anti-Inflammatory Effects of Vaccariae Hypaphorine in Endothelial Cells

Contact Info

Product

Resources

About