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Objective: to study the incidence of cervical cancer in women in urban and rural areas of the Republic of Buryatia.Materials and methods. The material of registered cases of cervical cancer for 30 years (1987–2019) is taken from the documentation of the Republican Oncological Dispensary, and calculations are carried out in intensive indicators of morbidity per 100,000 women in the whole Republic, in cities, in rural areas using data from the annual population. The prognostic assessment of the incidence of cervical cancer was carried out using the method of regression analysis by extrapolating the trend. All materials were processed using the programs Statistica 8.0 and Excel 2003 with a statistically significant level of p <0.05.Results. In the region, during the analyzed period, the incidence of cervical cancer among women is high, mainly in urban than in rural areas. However, the latter also have an upward trend. The most susceptible to this pathology is the age group active in the labor and social plan – 35–54 years. Conclusions. A feature of the morbidity process of women in the city was its earlier age, 25–29 years, and its peakthe period of 45–49 years. When forming high-risk groups, it is necessary to pay close attention to the category of rural women and take into account the age group most susceptible to this pathology.
Objective: to study the incidence of cervical cancer in women in urban and rural areas of the Republic of Buryatia.Materials and methods. The material of registered cases of cervical cancer for 30 years (1987–2019) is taken from the documentation of the Republican Oncological Dispensary, and calculations are carried out in intensive indicators of morbidity per 100,000 women in the whole Republic, in cities, in rural areas using data from the annual population. The prognostic assessment of the incidence of cervical cancer was carried out using the method of regression analysis by extrapolating the trend. All materials were processed using the programs Statistica 8.0 and Excel 2003 with a statistically significant level of p <0.05.Results. In the region, during the analyzed period, the incidence of cervical cancer among women is high, mainly in urban than in rural areas. However, the latter also have an upward trend. The most susceptible to this pathology is the age group active in the labor and social plan – 35–54 years. Conclusions. A feature of the morbidity process of women in the city was its earlier age, 25–29 years, and its peakthe period of 45–49 years. When forming high-risk groups, it is necessary to pay close attention to the category of rural women and take into account the age group most susceptible to this pathology.
The degree of morbidity of the population of the Republic of Buryatia with malignant neoplasms without subdivision by localization from 1996 to 2019 was analyzed according to the data of the Republican Clinical Oncological Dispensary. Material and methods. The data on the incidence of malignant neoplasms in the population of municipalities of the Buryat Republican Clinical Oncological Dispensary, expressed in intensive («rough») indicators (PI) per 100 thousand population (ppm, 0/0000) have been analyzed. The zoning of the incidence of the population has been based on the approach of medico-geographical typification of the territory. The range of indicators of the incidence of cancer in the population served as the basis for identifying four types of territories by the levels of cancer pathology: low – medium – high – very high. The dynamics of morbidity was analyzed by the average indicators of four 5-year periods (1996–2000, 2001–2005, 2006–2010, 2011–2015) and one 4-year period (2016–2019). Cartographic processing of the material was performed using Paint.NET. The comparison of morbidity in 21 municipal districts has been carried out. In period 1, there were 4 districts with low pathology (90–134 people): Okinsky, Muisky, Tunkinsky, Zakamensky districts, and with very high pathology (225–277 cases) – 4 districts: Pribaikalsky, Kabansky, Zaigraevsky, Bauntovsky. In the second period, the Okinsky, Tunkinsky, Dzhidinsky districts had low rates (100–158 cases), and the North-Baikalsky, Ivolginsky, Selenginsky, Kurumkansky, Mukhorshibirsky districts had very high level (257 and more). In the third period: low incidence rate (100–150 cases) has been determined in Muisky, Kizhinginsky districts, very high rate (274–331 cases) – in Bauntovsky, Kabansky, Zaigraevsky, Tarbagataisky districts. In the fourth period: low pathology rate (155–212 people) was in Okinsky, Zakamensky, Muisky, Eravninsky, Ivolginsky districts, very high level (329 cases) was in Bauntovsky district. In the last four years: low case rate (138–204) was only in Okinsky district, very high pathology level (339–405 people) was in 5 districts, to Bauntovsky, Kabansky, Pribaikalsky districts were added the northern districts: Severo-Baikalsky and Barguzinsky. Territories with high indicators of malignant neoplasms include: Pribaikalsky (393.5 ± 39.9 0/0000), Kabansky (397.5 ± 21.9 0/0000), Zaigraevsky (318.2 ± 13.6 0/0000), Bauntovsky (403.6 ± 51.6 0/ 0000); with reduced ones – Zakamensky (241.1 ± 17.4 0/0000), Tunkinsky (215.9 ± 6.8 0/0000), Eravinsky (214.3 ± 16.5 0/0000), Okinsky (137.8 ± 6.1 0/0000) districts. The malignant neoplasms incidence of the population of the Republic Buryatia is high, and it is growing every year.
Introduction. Petrochemical and refinery enterprises generate up to 80 % of emissions from all stationary sources in Ufa. Air toxic pollution can threaten public health. The purpose of the study is to conduct hygienic impact assessment of emissions from petrochemical and refinery enterprises on cancer morbidity in Ufa. Materials and Methods. The authors examined the data on air carcinogen concentrations and indicators of general mortality, primary cancer morbidity, patient cohorts with malignant neoplasms and cancer mortality rate in Ufa between 2007 and 2017. They also calculated Pearson correlation coefficients and carcinogenic risks. Results. At some instants, benzene, gasoline, ethylbenzene and ethenylbenzene concentrations exceeded the maximum permissible concentration 5 times or more; concentrations of formaldehyde, benzo(a)pyrene and carbon (soot) were 2 times higher than the norm. In 2007–2017, the rate of newly diagnosed cancer morbidity increased by 6.0 %, the number of cancer patients – by 6.9 %. Over the last 4 years, cancer mortality rate reached its maximum during the given period, namely 200.1 per 100 000 people (mean value between 2007 and 2017 was 165.6±15.6). The authors revealed a close correlation between the patient cohort with malignant neoplasms and carbon (r=0.74) or ethylbenzene (r=0.63) emissions. The trichloromethane concentration was closely correlated with indicators of primary cancer morbidity (r=0.82) and mortality (r=0.78). The rate of carcinogenic risks due to air pollution was 9.0×10-4, i.e. unacceptably high. The rate of population aerogenic carcinogenic risks resulted in 1000 additional cases of malignant neoplasms. Conclusion. If there are no changes in the existing levels of air pollution in Ufa, further environmental aggravation associated with carcinogenic risks and reduction in life expectancy among Ufa residents can be possible. Keywords: air pollution, carcinogens, cancer morbidity and mortality, public health risks. В Уфе предприятия нефтехимии и нефтепереработки формируют до 80 % выбросов от всех стационарных источников. Загрязнение воздушного бассейна токсичными веществами может представлять опасность для здоровья населения мегаполиса. Цель исследования. Гигиеническая оценка влияния выбросов предприятий нефтехимии и нефтепереработки на онкологическую заболеваемость населения г. Уфы. Материалы и методы. Проанализированы данные о содержании в атмосферном воздухе г. Уфы химических веществ, обладающих канцерогенным действием, а также показатели общей смертности населения, первичной онкологической заболеваемости, контингента больных злокачественными новообразованиями и смертности от онкологических заболеваний за 2007–2017 гг. Рассчитаны коэффициенты корреляции Пирсона и уровни канцерогенного риска. Результаты. Содержание бензола, бензина, этилбензола и этенилбензола в отдельные периоды времени превышало предельно допустимую концентрацию в 5 и более раз; формальдегида, бенз(а)пирена и углерода (сажи) – в 2 раза. Уровень впервые выявленной онкологической заболеваемости за 2007–2017 гг. повысился на 6,0 %, уровень контингента онкобольных – на 6,9 %. Смертность от онкологических заболеваний за последние 4 года достигла максимума за весь рассматриваемый период – 200,1 на 100 тыс. населения (средний показатель за 2007–2017 гг. – 165,6±15,6). Выявлена тесная корреляционная связь между контингентом больных злокачественными новообразованиями и выбросами углерода (r=0,74), этилбензола (r=0,63). Содержание трихлорметана тесно коррелирует с показателями первичной онкологической заболеваемости (r=0,82) и смертности от онкологии (r=0,78). Уровень суммарного канцерогенного риска, обусловленного загрязнением атмосферного воздуха, составляет 9,0×10-4, что классифицируется как неприемлемый. Уровень популяционного аэрогенного канцерогенного риска составляет 1000 дополнительных (к фоновому) случаев злокачественных новообразований. Выводы. При сохранении существующих уровней загрязнения атмосферного воздуха г. Уфы возможно дальнейшее обострение экологических проблем, связанных с канцерогенными рисками, и сокращение продолжительности жизни жителей мегаполиса. Ключевые слова: загрязнение атмосферного воздуха, канцерогены, онкологическая заболеваемость и смертность, риски здоровью населения.
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