Morphologic changes in the anterior and posterior subregions of V1 and V2 and the V5/MT+ in patients with primary open-angle glaucoma

Yu, Longhua; Yin, Xuntao; Dai, Chao; Liang, Minglong; Wei, Luqing; Li, Chuanming; Zhang, Jiuquan; Xie, Bing; Wang, Jian

doi:10.1016/j.brainres.2014.09.005

Cited by 30 publications

(35 citation statements)

References 60 publications

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“…Decreased cortical thickness was detected in the V5/MTþ area in patients with early glaucoma, while in advanced cases it was present in both V5/MTþ and anterior subregions of V1. 31 This finding is consistent with the concept that the magnocellular pathway may be affected earlier than the parvocellular pathway in glaucoma. 12 Although a primary neurodegenerative process in the brain cannot be excluded, the retinotopic and disease severity-related cortical changes in glaucoma suggest a type of secondary anterograde transsynaptic degeneration, or cortical plasticity, primed by the death of RGCs and absence of stimulation from the areas of visual field defects in glaucoma.…”

Section: Discussionsupporting

confidence: 81%

Retinotopic Changes in the Gray Matter Volume and Cerebral Blood Flow in the Primary Visual Cortex of Patients With Primary Open-Angle Glaucoma

Zhang

Wang

Xie

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionsupporting

confidence: 81%

Retinotopic Changes in the Gray Matter Volume and Cerebral Blood Flow in the Primary Visual Cortex of Patients With Primary Open-Angle Glaucoma

Zhang

Wang

Xie

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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“…Previous studies with low vision patients with glaucoma and macular degeneration reported reduced gray matter volume in occipital cortex consistent with the visual field scotomata (Bogorodzki et al, 2014, Boucard et al, 2009, Burge et al, 2016, Chen et al, 2013, Gupta et al, 2006, Hernowo et al, 2014, Kitajima et al, 1997, Kitsos et al, 2009, Olivo et al, 2015, Plank et al, 2011, Prins et al, 2016a, Prins et al, 2016b, Yu et al, 2014, Yu et al, 2013, Zikou et al, 2012). Retinal ganglion cell degeneration in glaucoma, and also in macular degeneration after photoreceptors death, may cause transneuronal degeneration along visuo-cortical pathways, leading to neuronal atrophy in visual cortex.…”

Section: Discussionmentioning

confidence: 62%

“…Additionally, the majority of reports on structural changes combine several ophthalmological conditions involving distinct mechanisms, which may hinder the understanding of specific brain changes triggered by a particular disease (Anurova et al, 2014, Boldt et al, 2014, Dietrich et al, 2013, Erika et al, 2014, Lee et al, 2014, Lewald and Getzmann, 2013, Park et al, 2009, Plank et al, 2011, Renier et al, 2013, Wang et al, 2014, Weaver et al, 2013, Xie et al, 2012). Previous studies with advanced stage patients with glaucoma and macular degeneration (Bogorodzki et al, 2014, Boucard et al, 2009, Chen et al, 2013, Hernowo et al, 2014, Plank et al, 2011, Yu et al, 2014, Zikou et al, 2012) and blind participants (Anurova et al, 2014, Jiang et al, 2009, Pan et al, 2007, Park et al, 2009, Ptito et al, 2008) reported reduced gray matter volume in the occipital cortex.…”

Section: Introductionmentioning

confidence: 83%

Primary visual cortical remapping in patients with inherited peripheral retinal degeneration

Ferreira

Pereira

Quendera

et al. 2017

NeuroImage: Clinical

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Human studies addressing the long-term effects of peripheral retinal degeneration on visual cortical function and structure are scarce. Here we investigated this question in patients with Retinitis Pigmentosa (RP), a genetic condition leading to peripheral visual degeneration. We acquired functional and anatomical magnetic resonance data from thirteen patients with different levels of visual loss and twenty-two healthy participants to study primary (V1) visual cortical retinotopic remapping and cortical thickness. We identified systematic visual field remapping in the absence of structural changes in the primary visual cortex of RP patients. Remapping consisted in a retinotopic eccentricity shift of central retinal inputs to more peripheral locations in V1. Importantly, this was associated with changes in visual experience, as assessed by the extent of the visual loss, with more constricted visual fields resulting in larger remapping. This pattern of remapping is consistent with expansion or shifting of neuronal receptive fields into the cortical regions with reduced retinal input. These data provide evidence for functional changes in V1 that are dependent on the magnitude of peripheral visual loss in RP, which may be explained by rapid cortical adaptation mechanisms or long-term cortical reorganization. This study highlights the importance of analyzing the retinal determinants of brain functional and structural alterations for future visual restoration approaches.

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“…15,16 Another study however only found trends of reduced area and volume of V1 area and volume in glaucoma, but head size was not taken into account as a covariate. 32 Accounting for head size is likely important to detect differences as has been shown to be the case in the analysis of Alzheimer’s disease. 33 A possible explanation for the gray matter degeneration is that the loss of visual function in glaucoma leads to fewer neural signals to the visual cortex from the retina and other brain regions, resulting in the disuse-driven atrophy or shrinkage of neurons.…”

Section: Discussionmentioning

confidence: 99%

MRI Study of the Posterior Visual Pathways in Primary Open Angle Glaucoma

Zhou

Muir

Chalfin

et al. 2017

Journal of Glaucoma

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Purpose To evaluate neurodegeneration along brain visual pathways in primary open angle glaucoma (POAG) using improved analysis methods of volumetric and diffusion-tensor MRI data. Methods Eleven POAG patients (60.0±9.2yo) with primarily mild to moderate POAG and eleven age-matched controls (55.9±7.5yo) were studied using structural and diffusion-tensor MRI. Surface-based segmentation was applied to structural MRI to obtain visual cortical area and volume. Fiber tracking was applied to diffusion-tensor data to obtain diffusion parameters along the optic tract and optic radiation. MRI parameters in glaucoma patients were compared with the corresponding left and right visual fields and retinal nerve fiber layer thicknesses, instead of with the left and right eye. Results Area and volume of the primary visual cortex were significantly reduced in POAG patients compared to controls (P<0.05) but did not correlate with visual field loss. Fractional anisotropy was reduced at multiple locations along the optic tracts and optic radiations in POAG patients compared to controls. Axial and radial diffusivity along the fiber tracts showed trends but were not significantly different between POAG patients and controls when averaged over the whole structures. Only fractional anisotropy (P<0.05) of the optic radiations were significantly correlated with visual field loss. No MRI parameters were correlated with retinal nerve fiber layer thickness. Conclusions Improved analysis techniques of MRI data improves delineation of degeneration in the brain visual pathways and further supports the notion that neurodegeneration is involved with glaucoma pathogenesis.

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Morphologic changes in the anterior and posterior subregions of V1 and V2 and the V5/MT+ in patients with primary open-angle glaucoma

Cited by 30 publications

References 60 publications

Retinotopic Changes in the Gray Matter Volume and Cerebral Blood Flow in the Primary Visual Cortex of Patients With Primary Open-Angle Glaucoma

Retinotopic Changes in the Gray Matter Volume and Cerebral Blood Flow in the Primary Visual Cortex of Patients With Primary Open-Angle Glaucoma

Primary visual cortical remapping in patients with inherited peripheral retinal degeneration

MRI Study of the Posterior Visual Pathways in Primary Open Angle Glaucoma

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