Morphological studies of cell death in Mongolian gerbil parotid and submandibular gland acinar cells during aging.

Miyamoto, Hisatsugu; Qiu, Wenjuan

doi:10.2330/joralbiosci1965.39.641

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…This feature is comparable to that in the human study (9). Ischemic change of the vascularity has been suggested to be a causative factor for aging atrophy of the parenchyma (6, 7), and increase of the apoptotic cell death with age in the acini was assumed, as well (13). In this regard, the increased connective tissues around the blood vessels encountered for the old group in the present study seem to be responsible for the degenerative process in the acini, suggesting the subsequent replacement of the acinar tissue by connective and/or fatty tissues.…”

Section: Discussionsupporting

confidence: 83%

“…This evidence suggests that age-related fibrotic changes of the glandular tissues result in functional disorder of the salivary gland. The degeneration of acinar cells, cell death, and increased collagen fibers of connective tissues in Mongolian gerbil salivary gland has been reported (3,13). It is known that heat shock protein 47 (HSP47) plays an important role in the synthesis of collagen fibers by fibroblasts.…”

Section: Introductionmentioning

confidence: 99%

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Immunohistochemical Identification of HSP47 and Type I Procollagen-expressing Cells in Mongolian Gerbil Salivary Glands: Correlation with Age-related Fibrotic Changes

et al. 2004

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Identification of HSP47 and Type I Procollagen-expressing Cells in Mongolian Gerbil Salivary Glands: Correlation with Age-related Fibrotic Changes

et al. 2004

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The role of estrogen and Cu, Zn-SOD on histological changes after menopause in female rat parotid

Kusunoki¹,

Shiraishi²,

Murata³

2006

Auris Nasus Larynx

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Morphological Changes in the Rat Sublingual Gland Parenchyma with Aging

Kikuchi¹,

Aiyama²,

Ikeda³

et al. 2006

Gerontology

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Background: The characteristics of mucous cells in the aging rat sublingual gland were investigated in this study. Particular attention was paid to accumulated amyloid protein and changes of the properties of the secretory granules at the histochemical and ultrastructural level. Objective: This study was designed to examine age-related morphological changes in the sublingual gland of male Wistar rats from 12 to 27 months. Methods: For light microscopy, the sublingual glands were fixed with 10% neutral-buffered formalin, embedded in paraffin, and processed for Alcian blue, Congo red, and TUNEL staining. For transmission electron microscopy, some of the samples were fixed with Karnovsky solution, postfixed with 2% osmium tetroxide, and embedded in epoxy resin for pronase treatment. Results: The sublingual gland showed slight shrinkage after 21 months. After 24 months, Congo red staining showed positive reaction to the intralobular connective tissue surrounding the terminal portions and to the interlobular connective tissue around the blood vessels and the excretory ducts. At 27 months, some of the granules in the serous demilunes had difficulty in digesting with pronase treatment. The appearance rate of TUNEL-positive cells was low in both mucous and serous portions during the observation period, though the positive cell number was higher in the serous than in the mucous portion. Conclusions: These findings indicate that the rat sublingual gland accumulates amyloid protein in the parenchyma and changes the properties of secretory granules of the acinar cells in the serous demilune with aging, though apoptosis of the parenchymal cells and the decrease of the gland weight are slight.

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Morphological studies of cell death in Mongolian gerbil parotid and submandibular gland acinar cells during aging.

Cited by 3 publications

References 30 publications

Immunohistochemical Identification of HSP47 and Type I Procollagen-expressing Cells in Mongolian Gerbil Salivary Glands: Correlation with Age-related Fibrotic Changes

Immunohistochemical Identification of HSP47 and Type I Procollagen-expressing Cells in Mongolian Gerbil Salivary Glands: Correlation with Age-related Fibrotic Changes

The role of estrogen and Cu, Zn-SOD on histological changes after menopause in female rat parotid

Morphological Changes in the Rat Sublingual Gland Parenchyma with Aging

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