Mucosa-associated lymphoid tissue lymphoma of the thyroid with abundant IgG4-positive plasma cells

Miki, K.; Orita, Yorihisa; Sato, Yasuharu; Sugitani, Iwao; Noyama, Misato; Fuji, Sayaka; Domae, Shuhei; Nose, Soichiro; Hamaya, Kazuo; Yoshino, Tadashi; Nishizaki, Kazunori

doi:10.1016/j.anl.2012.12.004

Cited by 18 publications

(19 citation statements)

References 14 publications

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“…reported a case of MALT lymphoma involving the thyroid with abundant IgG4‐positive plasma cells. However, the neoplastic plasma cells in their case were IgG4‐negative . To the best of our knowledge, the case presented here represents the first case of an IgG4‐producing MALT lymphoma arising in a background of IgG4 thyroiditis, highlighting the importance of recognizing a distinctive subtype of MALT lymphoma that has rapid clinical progression and an absence of mass formation.…”

Section: Discussionmentioning

confidence: 81%

IgG4‐positive extranodal marginal zone lymphoma arising in Hashimoto's thyroiditis: clinicopathological and cytogenetic features of a hitherto undescribed condition

et al. 2015

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This represents the first case of IgG4-producing MALT lymphoma associated with IgG4 thyroiditis. IGH translocation with an unknown partner gene was identified. We suggest the performance of serum and immunohistochemical investigations for IgG and IgG4 in all cases of Hashimoto's thyroiditis to diagnose IgG4 thyroiditis. In addition, clonality assays and light chain studies are useful to exclude a low-grade lymphoma arising in this context.

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Section: Discussionmentioning

confidence: 81%

IgG4‐positive extranodal marginal zone lymphoma arising in Hashimoto's thyroiditis: clinicopathological and cytogenetic features of a hitherto undescribed condition

et al. 2015

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“…Concerning our patients, we didn't notice any antecedent of Hashimot's thyroiditis, but we suggest a pre-existing chronic thyroiditis within 3 patients having a biologic hypothyroidism. The most common clinical presentation is an enlarging painless neck mass, growing rapidly between 1 and 3 months at about 70% of cases (5,7,15) and causing an obstruction of the upper airway tract in an approximately 30% of cases (12) , most often we notice a dysphagia, dyspnea, rarely it's about stridor, hoarseness, dysphonia, or vena cava obstruction (11,12,13,14,16) . In our cases, the prevalent clinical presentation was a rapid enlarging goiter causing an obstruction of the upper airway revealing by dysphonia (paralysis of vocal cord) in one case of DLBCL, and dyspnea in another two cases ; first one was about a women aged 81 years consulting with dyspnea requiring an urgent intervention of desobstruction by tracheotomy, it was a DLBCL ; and for the second case we practice a CT that objective a huge goiter associated to a bilateral lymph nodes, there were a resolution of dyspnea after treatment by corticoids and chemotherapie, it was a rare case of MCL (mantle cell lymphoma).…”

Section: Discussionmentioning

confidence: 99%

Primary Thyroid Lymphoma : An Uncommon Etiology of Compressive Goiter

Meherzi¹,

Bellakhdher²,

Khaireddine³

et al. 2017

IAM

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Primary thyroid non-Hodgkin's lymphoma is a rare entity. It is defined as a lymphoma occurring in the thyroid gland with or without the involvement of regional lymph nodes. Diffuse large B-cell lymphoma is the predominant subtype, followed by the extranodal marginal zone B-cell lymphoma of MALT, mantle cell lymphoma, SLL, and follicular lymphoma. Hashimoto's thyroiditis is considering as a causal factor. Diffuse large B-cell lymphoma and mantle cell lymphoma are known by an aggressive course while MALT lymphoma and small lymphocytic lymphoma (SLL) are characterized by an indolent clinical course. The most common clinical presentation is an enlarging painless neck mass, growing rapidly and causing an obstruction of the upper airway. Differential diagnosis is an anaplastic carcinoma, squamous cell carcinoma, metastasis of unknown primary and thyroiditis. The sensitivity and the specificity of the FNAC can be increased if consolidated by the use of the flow cytometry, the immunohistochemistry (IHC) and PCR.Three modalities of treatment could be proposed: surgery, radiotherapy, and chemotherapy-dependent on the histologic subtype.

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“…Primary lymphoma of the thyroid gland is a rare pathology reported in few publications [1]- [3]. It is strongly associated with chronic lymphocytic thyroiditis [4].…”

Section: Discussionmentioning

confidence: 99%

“…NHL is characterized by clinical features and histological polymorphism inducing a lateness of the diagnosis and worsening the prognosis [1] [2]. NHL is not rare, and can be encountered in different specialties.…”

Section: Introductionmentioning

confidence: 99%

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Primary Thyroid Non-Hodgkin’s Lymphoma

Mahfoudhi¹,

Khammassi²,

Gorsane³

et al. 2015

OJPathology

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Primary non-Hodgkin's lymphoma of the thyroid gland was rarely described. We report the case of a 44-year-old man admitted for an anterior neck swelling, hoarseness and dyspnea. The chest radiograph showed a trachea deviation. He had no clinical, biological or radiological sign of other lymphoma locations. Ultrasound examination of the neck revealed a bilateral heterogeneous thyroid lesion. Cytology revealed lymphoid cells having high nuclear-cytoplasmic ratio with multiple and irregular nucleoli. An urgent thyroid surgery consisting of total thyroidectomy had been performed since the presence of compressive signs due to the tumor. The histopathological examination of a biopsy from the thyroid tissue confirmed a high-grade non-Hodgkin's lymphoma. Then, L-thyroxin substitution therapy, chemotherapy and radiotherapy were initiated. A prolonged remission was noted.

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Mucosa-associated lymphoid tissue lymphoma of the thyroid with abundant IgG4-positive plasma cells

Cited by 18 publications

References 14 publications

IgG4‐positive extranodal marginal zone lymphoma arising in Hashimoto's thyroiditis: clinicopathological and cytogenetic features of a hitherto undescribed condition

IgG4‐positive extranodal marginal zone lymphoma arising in Hashimoto's thyroiditis: clinicopathological and cytogenetic features of a hitherto undescribed condition

Primary Thyroid Lymphoma : An Uncommon Etiology of Compressive Goiter

Primary Thyroid Non-Hodgkin’s Lymphoma

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