Multifocal aggressive angiomyxoma: a case report

Abstract

A case of aggressive angiomyxoma in a 25 year old woman is presented. The patient was admitted to hospital with a history of hesitancy of micturation and pain in the right iliac fossa. She was found to have a left labial mass, which was clinically diagnosed to be a Bartholin gland cyst. A pelvic ultrasound revealed an additional mass in the right paravesical region. At surgery, two distinct masses were removed, one from the right perivesical space and the other from the left labium. Both masses were rubbery, white, and gelatinous and showed similar histopathology findings of thick and thin walled vascular channels set in a loose myxoid stroma. A diagnosis of multifocal aggressive angiomyxoma was made. This is the first reported case of aggressive angiomyxoma occurring as two distinct masses in one patient (J Clin Pathol 2000;53:798-799)

Extragenital Aggressive Angiomyxoma of the Axilla and the Chest Wall

“…However, encapsulated AAMs have also been reported [1,6,7] .The present case was different, as the tumour was well circumscribed. The histopathological features include hypocellularity, hapahazardly arranged blood vessels of varying calibres, a myxoid stroma with collagen fibres and extravasated erythrocytes.…”

A solitary encapsulated pelvic aggressive angiomyxoma

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Its radiological features have been described, being a displacing mass rather than infiltrating, with high signal intensity on T2-weighted images, 1,14,15 but these features can be attributed to the myxoid component of the tumour, shown by many other soft tissue tumours of mesenchymal origin. On gross examination, it was different in being well circumscribed non-lobulated and encapsulated, [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] but the gelatinous appearance, greyish discoloration on cross section and the large size of the tumour are common features of AAMs. These findings are attributed to the myxoid stroma that is rich in collagen fibres.…”

“…In addition, sporadic reports of recurrences in sites different than the originally excised mass, and the reports of unusual locations or presentations of this tumour, e.g. multifocal AAM, 20 the bladder, 12 and the uterine cavity 13 (e.g. polypoidal mass in the last two sites, occasionally), etc., are all in favour of an isolated primitive mesenchymal cell origin.…”

“…4,18 Complete excision is the treatment of choice. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] We believe that 1-2 yearly intervals of follow-up with alternate MRI and sonography is sufficient in view of the slow growing and nonmetastasising nature of this tumour.…”

Rare Case of Aggressive Angiomyxoma of the Vulva: A Case Report

“…Hence, wide local excision with negative margins is the optimal treatment.It is associated with frequent recurrences, probably due to incomplete removal or multifocal occurrence of these neoplasms (Kaur et al, 2000). This emphasizes the need for long term followup.Meticulous monitoring with clinical examination and imaging techniques is necessary before the possibility of a recurrence can be dismissed.…”