Multifocal motor neuropathy, type 1 diabetes and asymptomatic Hashimoto's thyroiditis: an unusual association

Reisin, Ricardo; Zurrú, Cristina; Buso, Carlos; Marchesoni, Cintia; Pardal, Ana; Jadzinsky, Mauricio

doi:10.1016/j.nmd.2005.01.008

Cited by 5 publications

(4 citation statements)

References 23 publications

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“…Autonomic neuropathy, cranial neuropathy and multifocal motor neuropathy have been documented to present asymptomatically. 13,14,15 The incidence of diabetic foot is higher in patients with poor glycaemic control. Early detection of peripheral neuropathy and appropriate management of the same will reduce the incidence of amputations due to diabetic foot.…”

Section: Discussionmentioning

confidence: 99%

A Cross-Sectional Study on the Prevalence of Distal Sensory Neuropathy in Asymptomatic Type 2 Diabetes Patients in a Tertiary Care Centre

Anbarasu¹,

Kumaresan²,

Vijayakumar³

et al. 2016

jemds

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OBJECTIVETo determine the prevalence of Distal Sensory neuropathy in asymptomatic Type 2 Diabetes mellitus. METHODOLOGYPatients with type 2 diabetes mellitus attending outpatient Department of Government Vellore Medical College Hospital without symptoms of peripheral neuropathy were included in this study. The presence of diabetic neuropathy was diagnosed using Michigan Neuropathy Screening Instrument (MNSI) Score. RESULTSA total of 400 patients with type 2 diabetes mellitus were studied of which 216 (54%) were males and 184 (46%) were females. Mean age of males was significantly higher than females (51±9.1 years vs. 44±7.6 years, p<0.05). The mean BMI of females was significantly higher for females than males (28.4±4.2 vs. 25.3±2.9, p<0.05). In our study, 72 patients (18%) had asymptomatic peripheral neuropathy. CONCLUSIONPeripheral neuropathy is common in asymptomatic diabetic patients. All patients with diabetes mellitus needs active screening for peripheral neuropathy to reduce the morbidity associated with it.

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Section: Discussionmentioning

confidence: 99%

A Cross-Sectional Study on the Prevalence of Distal Sensory Neuropathy in Asymptomatic Type 2 Diabetes Patients in a Tertiary Care Centre

Anbarasu¹,

Kumaresan²,

Vijayakumar³

et al. 2016

jemds

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“…[2][3][4][5][6][7][8][9][10] Immunoglobulin responsive motor neuropathy with multifocal conduction blocks with or without elevated GM1 antibodies in patients with Hashimoto's thyroiditis has also been noted. 11,12 Association of Hashimoto's thyroiditis with immune mediated renal pathology [13][14][15][16][17] , skin lesions 7,14,17 and encephalopathy 18 has been recognized earlier. The association of Hashimoto's thyroiditis, CIDP and membranous nephropathy has not been previously reported.…”

Section: Discussionmentioning

confidence: 99%

CIDP, Hashimoto’s Thyroiditis and Nephropathy: Autoimmune Syndrome Complex?

Raghavendra

Saran

Somashekar

et al. 2009

Can. J. Neurol. Sci

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BRIEF COMMUNICATIONS Figure: 1A-Fine needle aspirate from the thyroid shows dense lymphoid aggregate and islands of epithelial cells suggestive of disruption of thyroid acini in a case of Hashimoto's thyroiditis (HE X 160). 1B-Renal glomerulus showing focal mesangial prominence and prominent capillary basement membrane (HE X 200). Insert-a single afferent arteriole which showed perivascular infiltrate of lymphocytes and histiocytes (HE-320).

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“…multifocal motor neuropathy). [5][6][7] The diagnosis of amyotrophic lateral sclerosis (ALS) was not made because the El Escorial criteria (1998) were not fulfilled as signs of both upper and lower motor neuron lesions in the same body region were not found by clinical and paraclinical means. As typical features like positive familiar history, gynecomastia, testicular atrophy, gigantism or hyperglycemia were absent, cognitive impairment was obvious, and cranial MRI was abnormal, Kennedy disease was not 6 considered.…”

Section: Discussionmentioning

confidence: 99%

“…Another case of muscle weakness and atrophy due to multifocal motor conduction blocks and Hashimoto's thyroiditis in a 17-year-old man has been reported 2 years later. [6] In addition, an association of lymphocytic thyroiditis and peripheral neuropathy in 6 of 53 cases and of lymphocytic thyroiditis and encephalopathy in 2 of 53 cases has been described in 1990. [7] Here we report a patient with cognitive impairment associated with a lower motor neuron disease, which coincided with extremely high serum titers of antithyroid peroxidase (TPO) antibodies.…”

Section: Introductionmentioning

confidence: 99%

Hashimoto′s encephalopathy and motor neuron disease: A common autoimmune pathogenesis?

et al. 2006

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Hashimoto's encephalopathy is a rare complication of autoimmune thyroiditis not associated with thyroidal function decline. We report a 50-year-old man presenting with lower motor neuron symptoms evolving over 3 years and changes in behavior associated with attentive and cognitive impairment occurring in the last few months. Memory deficits, emotional instability, marked dysarthria, mild symmetric weakness of the lower extremities and fasciculations were the most striking clinical features. EEG was diffusely slow, cranial MRI revealed multiple subcortical white matter lesions, CSF protein was slightly elevated, electromyographic recordings showed acute and chronic denervation and extremely high TPO antibody titers were found in the serum. Hashimoto's encephalopathy and lower motor neuron disease were diagnosed. As repeated high-dose intravenous methylprednisolone administration followed by oral tapering improved both central nervous system and lower motor neuron symptoms, the question was raised whether there was a common autoimmune pathogenesis of both clinically distinct diseases.

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Multifocal motor neuropathy, type 1 diabetes and asymptomatic Hashimoto's thyroiditis: an unusual association

Cited by 5 publications

References 23 publications

A Cross-Sectional Study on the Prevalence of Distal Sensory Neuropathy in Asymptomatic Type 2 Diabetes Patients in a Tertiary Care Centre

A Cross-Sectional Study on the Prevalence of Distal Sensory Neuropathy in Asymptomatic Type 2 Diabetes Patients in a Tertiary Care Centre

CIDP, Hashimoto’s Thyroiditis and Nephropathy: Autoimmune Syndrome Complex?

Hashimoto′s encephalopathy and motor neuron disease: A common autoimmune pathogenesis?

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