Multifunctional Antioxidants for the Treatment of Age-Related Diseases

Abstract

Analogs of N,N-dimethyl-4-(pyrimidin-2-yl)-piperazine-1-sulfonamide possessing either a free radical scavenger group (FRS), chelating groups (CHL), or both (FRS+CHL) have been synthesized. Electrospray ionization mass spectrometry studies indicate that select members of this series bind ions in the relative order of Cu 1+ = Cu 2+ > Fe 2+ = Fe 3+ >Zn 2+ with no binding of Ca 2+ or Mg 2+ observed. In vitro evaluation of these compounds in human lens epithelial, human retinal pigmented epithelial, and human hippocampal astrocyte cell lines indicates that all analogs possessing the FRS group as well as the water soluble vitamin E analog 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid protect these cells against decreased cell viability and glutathione levels induced by hydrogen peroxide. In addition, those compounds possessing CHL groups also protected these cells against hydroxyl radicals generated by the Fenton reaction. These compounds are good candidates for the preventive treatment of cataract, age-related macular degeneration (AMD), and Alzheimer's dementia (AD).

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