Multilayer adsorption of amino acids on oxidized cellulose

Zimnitsky, Dmitry S.; Yurkshtovich, T. L.; Bychkovsky, Pavel M.

doi:10.1016/j.jcis.2004.12.021

Cited by 23 publications

(9 citation statements)

References 21 publications

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“…There has been significant effort to stimulate the bioactivity of cellulose. The substitution of functional groups (e.g., -COOH, -NH 2 ) was found to improve the bone-bonding ability of the cellulose derivates at the implant/tissue interface (27)(28)(29).…”

Section: Discussionmentioning

confidence: 99%

Proliferation and Osteoblastic Differentiation of hMSCs on Cellulose-Based Hydrogels

Raucci

Álvarez-Pérez

Demitri

et al. 2012

Journal of Applied Biomaterials & Functional Materials

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Section: Discussionmentioning

confidence: 99%

Proliferation and Osteoblastic Differentiation of hMSCs on Cellulose-Based Hydrogels

Raucci

Álvarez-Pérez

Demitri

et al. 2012

Journal of Applied Biomaterials & Functional Materials

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“…The concentration of these groups modulates not only the degradation time of cellulose, but also its pH, its swelling in a water environment, mechanical stability, drug loading efficiency and other behavior of the material (Zhu et al 2001). In addition, the -COOH groups, which are polar and negatively charged, can be used for functionalizing the oxidized cellulose with various biomolecules (Zimnitsky et al 2005(Zimnitsky et al , 2006.…”

Section: Introductionmentioning

confidence: 99%

Cellulose-based materials as scaffolds for tissue engineering

et al. 2013

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Two types of cellulose-based materials, 6-carboxycellulose with 2.1 or 6.6 wt% of -COOH groups, were prepared and tested for potential use in tissue engineering. The materials were functionalized with arginine, i.e. an amino acid with a basic side chain, or with chitosan, in order to balance the relatively acid character of oxidized cellulose molecules, and were seeded with vascular smooth muscle cells (VSMC). The cell adhesion and growth were then evaluated directly on the materials, and also on the underlying polystyrene culture dishes. Of these two types of studied materials, 6-carboxycellulose with 2.1 wt% of -COOH groups was more appropriate for cell colonization. The cells on this material achieved an elongated shape, while they were spherical in shape on the other materials. The number of cells and the concentration (per mg of protein) of contractile proteins alpha-actin and SM1 and SM2 myosins, i.e. markers of the phenotypic maturation of VSMC, were also significantly higher on this material. Functionalization of the material with arginine and chitosan further improved the phenotypic maturation of VSMC. Chitosan also improved the adhesion and growth of these cells. In comparison with the control polystyrene dishes, the proliferation of cells on our cellulose-based materials was relatively low. This suggests that these materials can be used in applications where high proliferation activity of cells is not desirable, e.g. proliferation of VSMC on vascular prostheses. Alternatively, the cell proliferation might be enhanced by another more efficient modification, which would require further research.

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“…This is connected with the fact that OC exchange capacity has not been reached during adsorption from dilute solutions. The adsorption from concentrated solutions of AA is characterized by the effect of multilayer adsorption, which was reported in [19].…”

Section: Mechanism Of Adsorption and Adsorption Isothermmentioning

confidence: 99%

“…However, these studies were primarily devoted to AA adsorption onto synthetic ion exchangers from aqueous solutions. The adsorption of some drugs onto OC was also studied [19][20][21][22]; however, the effect of important OC characteristics (exchange capacity, degree of crystallinity and swelling, surface area, etc.) on adsorption and adsorption from binary water/organic solutions remain unstudied.…”

Section: Introductionmentioning

confidence: 99%