Myocardial regeneration: Roles of stem cells and hydrogels

Ye, Zhaoyang; Zhou, Yan; Cai, Haibo; Tan, Wen‐Song

doi:10.1016/j.addr.2011.02.007

Cited by 78 publications

(53 citation statements)

References 136 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Glutaraldehyde was used to increase the stability of hydrogels. Considering its induction potential in in vivo vascularization and repair of damaged heart tissue (Li and Guan, 2011) as well as human myofibroblast proliferation and tissue regeneration and/or development (Ye et al, 2011), fibrinogen was preferred. HA is gaining popularity as a biomaterial for tissue engineering and tissue regeneration due to its high biocompatibility and low immunogenicity (Zheng et al, 2004;Leach et al, 2015) as well as its ability to promote cell migration (Yoo et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Cardiomyogenic differentiation potential of human lipoaspirate-derivedstem cells on hyaluronic acid/gelatin plasma gels

Göv¹,

Kenar²,

Halbutoğulları³

et al. 2016

Turk J Biol

View full text Add to dashboard Cite

Cardiomyogenic differentiation from mesenchymal stem cells has emerged as a novel approach for repair of damaged myocardium. Cell transplantation through direct cell injection is not an optimal method due to the lack of cell-extracellular matrix interactions. In the present study, differentiation potential of human adipose-derived stem cells (ASCs) to cardiomyocytes has been investigated by growing them on hyaluronic acid/gelatin (HA/G) plasma gels and coverslips and supplementing the growth medium with chemical modifiers (activin-a, BMP-4, insulin, valproic acid, and 5-azacytidine) in various combinations. The HA/G plasma gels were produced from human blood plasma-derived fibrinogen, gelatin, and human umbilical cord-derived hyaluronic acid. A networkbased approach was employed to select marker genes for cardiomyogenic differentiation, and the expression levels of three markers (GATA4, TBX5, and cTnI) were followed by RT-qPCR to investigate the cardiomyogenic differentiation potential of ASCs. Results indicated that each combination of chemical modifiers led to different expression levels in the aforementioned cardiac markers, and this was material-dependent, too. The cardiac gene expression on HA/G plasma gels in the presence of activin-a + BMP-4 or insulin + valproic acid was more pronounced than in the presence of 5-azacytidine only, and scaffold and chemical modifier combinations were crucial for cardiomyogenic differentiation.

show abstract

Section: Discussionmentioning

confidence: 99%

Cardiomyogenic differentiation potential of human lipoaspirate-derivedstem cells on hyaluronic acid/gelatin plasma gels

Göv¹,

Kenar²,

Halbutoğulları³

et al. 2016

Turk J Biol

View full text Add to dashboard Cite

show abstract

“…At the moment, polymers like collagen, fi brin, alginate, etc have been evaluated for their ability to form hydrogels in cardiac cell therapy/tissue engineering [5,17]. In table 1 are presented some examples of natural polymers and their principal properties.…”

Section: Natural Hydrogelsmentioning

confidence: 99%

“…Its role in the body is both structurally and functionally, as being involved in complex mechanisms regulating of tissue growth and recovery [3,17,25]. Collagen is wildly used in medical applications due its biocompatibility, biodegradability, weak antigenicity and mostly because can be mixed with therapeutic proteins and drugs [3,17,18]. This protein presents an environment conducive to cell viability, promoting cell attachment and proliferation [3].…”

Section: Collagenmentioning

confidence: 99%

See 1 more Smart Citation

Hydrogels for Cardiac Tissue Repair and Regeneration

Grigore¹

2017

J Cardiovasc Med Cardiol

View full text Add to dashboard Cite

The main cause of death in the world continues to be cardiovascular disease, which affects annually over 900,000 people and in the entire word approximately 50% of the people suffering myocardial infarction (MI) die within 5 years. MI causes a number of cardiac pathologies like hypertension, blocked coronary arteries and valvular heart diseases resulting ischemic cardiac injury. In the last years, cardiac tissue engineering has made considerable progress, because this progress have been made towards developing injectable hydrogels for the purpose of cardiac repair and/or regeneration. This study aims to provide an updated survey of the major progress in the fl ied of injectable cardiac tissue engineering, including biomaterials (natural, synthetic or hybrid hydrogels), their advantages or disadvantages and the main seeding cell sources. Also, this review focuses on the progress made in the fi eld of hydrogels for cardiac tissue repair and/or regeneration for MI over the last years.

show abstract

“…Cell-based approaches to increase the blood flow in the affected limb hold great promise in inducing therapeutic angiogenesis [1,3,4]. However, most current strategies of cell delivery result in very low engraftment efficiency and cell viability in ischemic tissues, limiting their therapeutic benefits [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%