Myoclonic status epilepticus following repeated oral ingestion of colloidal silver

Mirsattari, Seyed M.; Hammond, Rob; Sharpe, Michael D.; Leung, F Y; Young, G. Bryan

doi:10.1212/01.wnl.0000120671.73335.ec

Cited by 81 publications

(54 citation statements)

References 9 publications

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“…To our knowledge, this is the first report of corticobasal degeneration and myoclonic seizures associated with high levels of silver in serum. Our case differs from a previous report of myoclonic seizures in association with silver ingestion, 1 where the patient had used a homemade colloidal silver for four months. Our patient developed a slowly progressive neurodegenerative disorder over a period of four years, the onset of his symptoms following the commencement of his self-medication with a colloidal silver preparation.…”

Section: Discussioncontrasting

confidence: 99%

Unintentional silver intoxication following self-medication: an unusual case of corticobasal degeneration

Stępień¹,

Morris

Brown³

et al. 2009

Ann Clin Biochem

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Silver toxicity is a rare condition. The most notable feature is a grey-blue discoloration of the skin, argyria, although harmful effects on the liver and kidney may be seen in severe cases. Neurological symptoms are an unusual consequence of silver toxicity. So far no effective treatment has been described for this metal overdose. We report the case of a 75-year-old man who had a history of self-medication with colloidal silver and presented with myoclonic seizures. 2009; 46: 520-522. DOI: 10.1258 46: 520-522. DOI: 10. /acb.2009 Case A 75-year-old male, former electronic engineer, was admitted to hospital with fever, a chest infection and myoclonic seizures. He had a four-year history of a gradually progressive neurodegenerative disorder characterized by asymmetrical parkinsonism and myoclonic jerks initially affecting the left upper limb. There had been some progression of the akinetic-rigid symptoms to the right side and he had developed some alien limb phenomena in the left arm accompanied by a prominent grasp reflex. On the basis of these clinical findings, a diagnosis of corticobasal degeneration had been made. Although he had been treated with a combination of dopamine agonists and levodopa, there had been little clinical response. In the 12 months prior to this admission, he had increasing difficulty swallowing and was hospitalized on several occasions with probable aspiration pneumonia. Other significant past medical history included ischaemic heart disease, mild asthma and non-insulin-dependent diabetes mellitus. His medications at presentation included co-beneldopa (levadopa and benserazide), ropirinole, simvastatin, aspirin and ramipril. Ann Clin BiochemAt admission to hospital, signs of a highly asymmetric ( predominantly left sided) akinetic-rigid syndrome were confirmed. In addition, frequent and sustained myoclonic jerky movements of the left upper limb were noted. There were signs of a right-sided lower respiratory tract infection but examination of the cardiovascular and gastrointestinal systems were essentially unremarkable. An inconsistent failure of ocular pursuit movements was noted later in the course of his admission and apart from his dysphagia, no other cranial nerve abnormalities were apparent. There was no pyramidal weakness and there was no discoloration of the patient's skin. The sclerae and mucosae were normal in appearance.A series of analytical investigations were performed. The majority were within reference ranges except for the serum selenium of 0.58 mmol/L (reference range: 0.89 -1.65). A chest X-ray confirmed that there was patchy air space and peribronchial shadowing in the right mid and upper zones consistent with infective change. The results of computed tomography of the head showed generalized brain volume loss and mild periventricular chronic ischaemic changes. Magnetic resonance imaging of the brain showed changes consistent with moderate global cerebral atrophy, with more pronounced widening of parietal sulci. Signal changes were noted in the pons and the pos...

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Section: Discussioncontrasting

confidence: 99%

Unintentional silver intoxication following self-medication: an unusual case of corticobasal degeneration

Stępień¹,

Morris

Brown³

et al. 2009

Ann Clin Biochem

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“…38 Although there is a lack of evidence regarding the relationship between NPs and CNS diseases in human studies to date, animal research suggests possible links. For example, Mirsattari et al 39 reported a case of a 71-year-old man who developed myoclonic status epilepticus and went into a coma after daily ingestion of colloidal silver for 4 months. High levels of silver were found in the plasma, erythrocytes, and CSF of the patient.…”

Section: Relationship Between Nms and Cns Dysfunctionmentioning

confidence: 99%

Central nervous system toxicity of metallic nanoparticles

Feng¹,

Chen²,

Zhang³

et al. 2015

IJN

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Nanomaterials (NMs) are increasingly used for the therapy, diagnosis, and monitoring of disease- or drug-induced mechanisms in the human biological system. In view of their small size, after certain modifications, NMs have the capacity to bypass or cross the blood–brain barrier. Nanotechnology is particularly advantageous in the field of neurology. Examples may include the utilization of nanoparticle (NP)-based drug carriers to readily cross the blood–brain barrier to treat central nervous system (CNS) diseases, nanoscaffolds for axonal regeneration, nanoelectromechanical systems in neurological operations, and NPs in molecular imaging and CNS imaging. However, NPs can also be potentially hazardous to the CNS in terms of nano-neurotoxicity via several possible mechanisms, such as oxidative stress, autophagy, and lysosome dysfunction, and the activation of certain signaling pathways. In this review, we discuss the dual effect of NMs on the CNS and the mechanisms involved. The limitations of the current research are also discussed.

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“…In the alternative medicine world, use of e.g. colloidal silver for oral intake is increasingly popular although the users might run a serious health risk (Mirsattari et al 2004).…”

Section: Introductionmentioning

confidence: 99%

In vivo liberation of silver ions from metallic silver surfaces

Danscher

Locht

2009

Histochem Cell Biol

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In vivo liberation of electrically charged silver atoms/silver ions from metallic silver pellets, silver grids and silver threads placed in the brain, skin and abdominal cavity was proved by way of the histochemical technique autometallography (AMG). A bio-film or "dissolution membrane" inserted between the metallic surface and macrophages was recognized on the surface of the implanted silver after a short period of time. Bio-released silver ions bound in silver-sulphur nanocrystals were traced within the first 24 h in the "dissolution membrane" and the "dissolucytotic" macrophages. In animals that had survived 10 days or more, silver nanocrystals were detected both extra- and intracellularly in places far away from the implant including regional lymph nodes, liver, kidneys and the central nervous system (CNS). The accumulated silver was always confined to lysosome-like organelles. Dissolucytotic silver was extracellularly related to collagen fibrils and fibres in connective tissue and basement membranes. Our study demonstrates that (1) the number of bio-released silver ions depends on the size of the surface of the implanted silver, (2) the spread of silver ions throughout the body takes place primarily not only through the vascular system, but also by retrograde axonal transport. It is concluded that implantation of silver or silver-plated devices is not recommendable.

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Myoclonic status epilepticus following repeated oral ingestion of colloidal silver

Cited by 81 publications

References 9 publications

Unintentional silver intoxication following self-medication: an unusual case of corticobasal degeneration

Unintentional silver intoxication following self-medication: an unusual case of corticobasal degeneration

Central nervous system toxicity of metallic nanoparticles

In vivo liberation of silver ions from metallic silver surfaces

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