Myxoinflammatory Fibroblastic Sarcoma: A Radiographical, Pathological, and Immunohistochemical Report of Rare Malignancy

Abstract

Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare, painless, and intermediate (rarely metastasizing) fibroblastic tumor, which commonly occurs in the extremities, with an equal sex predilection. This sarcoma is composed of a mixed inflammatory infiltrate along with spindled, epithelioid, and bizarre tumor cells in a background of hyaline and myxoid areas. In spite of such a distinctive morphology, the tumor can be a diagnostic challenge, simulating inflammatory conditions as well as neoplastic nature. For accurate diagnosis, the tumor requires extensive clinical, radiological, and pathological investigations. We present a case of MIFS in a 19-year-old female who presented with a mass in the left ankle. After appropriate excision and postoperative radiation therapy, she is free of disease, including recurrence and metastasis, at 12 years postoperatively.

Establishment of a spontaneously transformed cell line (JU-PI) from a myxoinflammatory fibroblastic sarcoma

“…MIFS most frequently arises as a painless slow-growing tumor in the distal extremities of adults in their 40s with no obvious gender predominance. [1][2][3] The histology of MIFS may be pleomorphic, which makes initial diagnostics challenging. The tumor consists of spindle cells and epithelioid cells with abundant cytoplasm.…”

Myxoinflammatory fibroblastic sarcoma of the submandibular gland

“…Malignant fibrous histiocytoma and liposarcoma contain myxoid focus and dispersed multivacuolated cells, and therefore they may cause confusion. [14] Myxoinf lammatory fibroblastic sarcoma is a malignant situation that can exhibit local recurrence. Regional recurrence rates have been reported to be between 22% and 67% within three months to five years.…”

“…Distant metastases generally occur in the inguinal lymph nodes, lungs, and livers, but mortality rates are substantially low. [14,15] There is no known clinical or pathological parameter that could be used to determine the biological behavior of the tumor. The best approach involves a large resection, follow-up, and a systemic oncological examination with workups including the chest to detect any metastasis.…”