Nano Au@Cu2-xS with near-infrared photothermal and peroxidase catalytic activities redefines efficient antibiofilm-oriented root canal therapy

Cao, Jun; Sun, Qing; Shen, Aiguo; Fan, Bing; Hu, Jiming

doi:10.1016/j.cej.2021.130090

Cited by 31 publications

(21 citation statements)

References 39 publications

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“…Recent advancements in the field of nanozymes have been significantly enhanced because of their mass manufacturing and low cost compared to natural enzymes. Reportedly, iron oxide nanoparticles, because of their peroxidase activity, may be used in endodontic disinfection to increase the antibacterial activity of root canal surfaces against Enterococcus faecalis . Moreover, it was also discovered that magnetic nanoparticles accelerated H 2 O 2 -induced oxidative cleavage of Pseudomonas aeruginosa biofilm components .…”

Section: Nanozymes As Antibacterial and Antibiofilm Agentmentioning

confidence: 99%

Recent Advancements in the Formulation of Nanomaterials-Based Nanozymes, Their Catalytic Activity, and Biomedical Applications

Singh,

Rai,

Tiwari

et al. 2023

ACS Appl. Bio Mater.

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Nanozymes are nanoparticles with intrinsic enzyme-mimicking properties that have become more prevalent because of their ability to outperform conventional enzymes by overcoming their drawbacks related to stability, cost, and storage. Nanozymes have the potential to manipulate active sites of natural enzymes, which is why they are considered promising candidates to function as enzyme mimetics. Several microscopy- and spectroscopy-based techniques have been used for the characterization of nanozymes. To date, a wide range of nanozymes, including catalase, oxidase, peroxidase, and superoxide dismutase, have been designed to effectively mimic natural enzymes. The activity of nanozymes can be controlled by regulating the structural and morphological aspects of the nanozymes. Nanozymes have multifaceted benefits, which is why they are exploited on a large scale for their application in the biomedical sector. The versatility of nanozymes aids in monitoring and treating cancer, other neurodegenerative diseases, and metabolic disorders. Due to the compelling advantages of nanozymes, significant research advancements have been made in this area. Although a wide range of nanozymes act as potent mimetics of natural enzymes, their activity and specificities are suboptimal, and there is still room for their diversification for analytical purposes. Designing diverse nanozyme systems that are sensitive to one or more substrates through specialized techniques has been the subject of an in-depth study. Hence, we believe that stimuli-responsive nanozymes may open avenues for diagnosis and treatment by fusing the catalytic activity and intrinsic nanomaterial properties of nanozyme systems.

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Section: Nanozymes As Antibacterial and Antibiofilm Agentmentioning

confidence: 99%

Recent Advancements in the Formulation of Nanomaterials-Based Nanozymes, Their Catalytic Activity, and Biomedical Applications

Singh,

Rai,

Tiwari

et al. 2023

ACS Appl. Bio Mater.

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“…As shown in Figure e and Figure S18, the BTO@Au nanoparticles were clearly observed on the surface of piezoGP. Enterococcus faecalis ( E. faecalis ), an opportunistic pathogen associated with root canal infection, , was selected to establish a root canal infection model. The E.…”

Section: Resultsmentioning

confidence: 99%

Surface-Confined Piezocatalysis Inspired by ROS Generation of Mitochondria Respiratory Chain for Ultrasound-Driven Noninvasive Elimination of Implant Infection

et al. 2023

ACS Nano

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Implant-associated infections (IAI) are great challenges to medical healthcare and human wellness, yet current clinical treatments are limited to the use of antibiotics and physical removal of infected tissue or the implant. Inspired by the protein/membrane complex structure and its generation of reactive oxygen species in the mitochondria respiration process of immune cells during bacteria invasion, we herein propose a metal/piezoelectric nanostructure embedded on the polymer implant surface to achieve efficient piezocatalysis for combating IAI. The piezoelectricity-enabled local electron discharge and the induced oxidative stress generated at the implant−bacteria interface can efficiently inhibit the activity of the attachedStaphylococcus aureusby cell membrane disruption and sugar energy exhaustion, possess high biocompatibility, and eliminate the subcutaneous infection by simply applying the ultrasound stimulation. For further demonstration, the treatment of root canal reinfection with simplified procedures has been achieved by using piezoelectric gutta-percha implanted in ex vivo human teeth. This surface-confined piezocatalysis antibacterial strategy, which takes advantage of the limited infection interspace, easiness of polymer processing, and noninvasiveness of sonodynamic therapy, has potential applications in IAI treatment.

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“…However, after laser irradiation, there was a significant decrease in cell viability 7 min afterward at 0.7 W/cm 2 laser power density. Another report revealed that Au@Cu 2– x S was biocompatible and guaranteed biosafety at a concentration of 128 μg/mL, with MC3T3-E1 cell viability exceeding 95% . Liu et al also reported that MCF-7 cells exposed to Au@Cu 2 S nanocrystals at concentrations of 720 and 45 ppm had a viability of approximately 20 and 70%, respectively, after 24 h. The enhanced surface area and the inhibition of the assembly of AuCu and Cu 2 –S in the composite material are significant factors for heightening cytotoxic effects .…”

Section: Cytotoxicity Study Of Aucu–cu2smentioning

confidence: 99%

Cytotoxicity of AuCu–Cu₂S Nanocomposites: Implications for Biological Evaluation of the Nanocomposite Effect on Bombyx mori Silkworms and Cell Lines

Andoh,

Shi,

et al. 2023

ACS Biomater. Sci. Eng.

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AuCu–Cu2S nanocomposites are unique materials with exceptional properties that have recently received a lot of interest. However, little is known about their potential toxicity in terrestrial organisms and their subsequent effects on the environment. Therefore, it is essential to develop effective methodologies for evaluating AuCu–Cu2S nanocomposites in biological systems. This study reports the biological evaluation of the AuCu–Cu2S nanocomposite from animal and cell entity levels. The Bombyx mori silkworm was used as a model organism to study the effects of different concentrations of AuCu–Cu2S on silkworm development. Transcriptome analysis was also carried out to examine the genetic modulation exerted by the treatment. Moreover, biocompatibility and cytotoxicity of AuCu–Cu2S were evaluated in human bronchial epithelial cells 16HBE, human lung adenocarcinoma, and the insect Spodoptera frugiperda cell sf9 cell lines. The results showed that although AuCu–Cu2S at ≤400 ppm can prolong the eating habit of silkworms and promote the weight of the cocoon layer, there was an increase in silkworm mortality and a decrease in moth formation at a concentration of ≥800 ppm. The genetic regulation by AuCu–Cu2S treatment showed varying effects in the silkworm, primarily related to functions such as transport and catabolism, metabolism of cofactors and vitamins, xenobiotic biodegradation, amino acid, and carbohydrate. 16HBE, PC-9, and sf9 treated with 300 ppm of AuCu–Cu2S showed viability percentages of 60, 20, and 90%, respectively. Thus, AuCu–Cu2S at low concentrations serves as a safe and biocompatible material for the sf9 cell lines but is lethal to 16HBE and PC-9. This research could aid in understanding the biological effects and biocompatibility of AuCu–Cu2S nanocomposites, particularly in the field of biochemistry; however, the mechanisms involved need further exploration.

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Nano Au@Cu2-xS with near-infrared photothermal and peroxidase catalytic activities redefines efficient antibiofilm-oriented root canal therapy

Cited by 31 publications

References 39 publications

Recent Advancements in the Formulation of Nanomaterials-Based Nanozymes, Their Catalytic Activity, and Biomedical Applications

Recent Advancements in the Formulation of Nanomaterials-Based Nanozymes, Their Catalytic Activity, and Biomedical Applications

Surface-Confined Piezocatalysis Inspired by ROS Generation of Mitochondria Respiratory Chain for Ultrasound-Driven Noninvasive Elimination of Implant Infection

Cytotoxicity of AuCu–Cu₂S Nanocomposites: Implications for Biological Evaluation of the Nanocomposite Effect on Bombyx mori Silkworms and Cell Lines

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Nano Au@Cu2-xS with near-infrared photothermal and peroxidase catalytic activities redefines efficient antibiofilm-oriented root canal therapy

Cited by 31 publications

References 39 publications

Recent Advancements in the Formulation of Nanomaterials-Based Nanozymes, Their Catalytic Activity, and Biomedical Applications

Recent Advancements in the Formulation of Nanomaterials-Based Nanozymes, Their Catalytic Activity, and Biomedical Applications

Surface-Confined Piezocatalysis Inspired by ROS Generation of Mitochondria Respiratory Chain for Ultrasound-Driven Noninvasive Elimination of Implant Infection

Cytotoxicity of AuCu–Cu2S Nanocomposites: Implications for Biological Evaluation of the Nanocomposite Effect on Bombyx mori Silkworms and Cell Lines

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Cytotoxicity of AuCu–Cu₂S Nanocomposites: Implications for Biological Evaluation of the Nanocomposite Effect on Bombyx mori Silkworms and Cell Lines