Nanofibrous scaffolds with biomimetic structure

Khalili, Shahla; Khorasani, Saied Nouri; Razavi, Mohammad; Beni, Batol Hashemi; Heydari, Farhad; Tamayol, Ali

doi:10.1002/jbm.a.36246

Cited by 33 publications

(23 citation statements)

References 18 publications

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“…By contrast, the scaffolds with a higher content of cellulose acetate and a lower content of gelatin (ratio 75:25) appeared to be suitable for low-adherent wound dressings [208]. Other cellulose acetate-based scaffolds with potential for skin tissue engineering include composite 3D electrospun cellulose acetate/pullulan scaffolds, which promoted the adhesion and growth of mouse L929 fibroblasts [209], and composite biomimetic nanofibrous gelatin/cellulose acetate/elastin scaffolds, which promoted the adhesion and growth of human gingival fibroblasts [210]. CNCs have a very large elasticity modulus (about 130 GPa), which is similar to that of Kevlar, and they have high strength (about 7 GPa).…”

Section: Plant-and Algae-derived Nanocellulose In Skin Tissue Engineementioning

confidence: 99%

Nanocellulose in Biotechnology and Medicine: Focus on Skin Tissue Engineering and Wound Healing

Bacakova¹,

Pajorová²,

Bačáková³

et al. 2018

Preprint

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Nanocellulose is cellulose in the form of nanostructures, i.e. features not exceeding 100 nm at least in one dimension. These nanostructures include nanofibrils, e.g. in bacterial cellulose; nanofibers, e.g. in electrospun matrices; nanowhiskers and nanocrystals. These structures can be further assembled into bigger 2D and 3D nano-, micro- and macro-structures, such as nanoplatelets, membranes, films, microparticles and porous macroscopic matrices. There are four main sources of nanocellulose: bacteria (Gluonacetobacter), plants (trees, shrubs, herbs), algae (Cladophora) and animals (Tunicata). Nanocellulose has emerged for a wide range of industrial, technology and biomedical applications, e.g. for adsorption, ultrafiltration, packaging, conservation of historical artifacts, thermal insulation and fire retardation, energy extraction and storage, acoustics, sensorics, controlled drug delivery, and particularly for tissue engineering. Nanocellulose is promising for use in scaffolds for engineering of blood vessels, neural tissue, bone, cartilage, liver, adipose tissue, urethra and dura mater, for repairing connective tissue and congenital heart defects, and for constructing contact lenses and protective barriers. This review is focused on applications of nanocellulose in skin tissue engineering and wound healing as a scaffold for cell growth, for delivering cells into wounds, and as a material for advanced wound dressings coupled with drug delivery, transparency and sensorics. Potential cytotoxicity and immunogenicity of nanocellulose are also discussed.

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Section: Plant-and Algae-derived Nanocellulose In Skin Tissue Engineementioning

confidence: 99%

Nanocellulose in Biotechnology and Medicine: Focus on Skin Tissue Engineering and Wound Healing

Bacakova¹,

Pajorová²,

Bačáková³

et al. 2018

Preprint

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“…The largest organ in human is skin with an area of about 2 m 2 . The skin has three different layers: including epidermis, dermis, and hypodermis, which intrinsically are self‐renewable and have various functions .…”

Section: Introductionmentioning

confidence: 99%

Wound dressings: Current advances and future directions

Ghomi

Khalili

Khorasani

et al. 2019

J of Applied Polymer Sci

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608

247

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Wound healing is a complicated and continuous process affected by several factors, which needs an appropriate surrounding to achieve accelerated healing. Wound healing process recruits three different phases: inflammation, proliferation, and maturation. Due to the different types of wounds, as well as the advancement in medical technology, various products have been developed to repair different skin lesions. Our objective is to investigate the advancement in wound dressings from traditional to the current methods of treatment. The article presents the characteristics of an ideal wound dressing, the requirements for the appropriate selection of different types of wounds, and a detailed classification of wound dressings. Animal origin, herbal origin, and synthetic dressings are firstly introduced and reviewed. Then, nonmedicated dressings including alginate, hydrogel, and hydrocolloid dressings, as well as medicated dressings are discussed. Finally, the developmental prospectives of the new generations of wound dressings for future researches are presented. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47738.

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“…Therefore, the nanofibers from gelatin/cellulose acetate (CA) with 0 to 10% (wt/wt) elastin were prepared using electrospinning technique. The formulations and processing condition were set according to the published research . Scaffolds were then cross‐linked using glutaraldehyde vapor at 40°C for 6 hours.…”

Section: Introductionmentioning

confidence: 99%

“…The formulations and processing condition were set according to the published research. 3 Scaffolds were then cross-linked using glutaraldehyde vapor at 40°C for 6 hours.…”

Section: Introductionmentioning

confidence: 99%