Theoretical cross‐link density of the nanofibrous scaffolds

Wound healing is a complicated and continuous process affected by several factors, which needs an appropriate surrounding to achieve accelerated healing. Wound healing process recruits three different phases: inflammation, proliferation, and maturation. Due to the different types of wounds, as well as the advancement in medical technology, various products have been developed to repair different skin lesions. Our objective is to investigate the advancement in wound dressings from traditional to the current methods of treatment. The article presents the characteristics of an ideal wound dressing, the requirements for the appropriate selection of different types of wounds, and a detailed classification of wound dressings. Animal origin, herbal origin, and synthetic dressings are firstly introduced and reviewed. Then, nonmedicated dressings including alginate, hydrogel, and hydrocolloid dressings, as well as medicated dressings are discussed. Finally, the developmental prospectives of the new generations of wound dressings for future researches are presented. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47738.

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“…Nanofibers fabricated from electrospinning method showed a promising approach in the tissue engineering applications . Therefore, Zhou et al .…”

Section: Classification Of Wound Dressingsmentioning

confidence: 99%

Wound dressings: Current advances and future directions

Ghomi

Khalili

Khorasani

et al. 2019

J of Applied Polymer Sci

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“…The pore size of the scaffold was increased from 2.6 to 5.5 µm during the crosslinking process, due to the fusion of the fibers together. Other researchers also reported an increase in the fiber diameter and pore size of the scaffolds during crosslinking with glutaraldehyde vapor [19,[33][34][35]. Increasing the pore size of the electrospun scaffolds for tissue engineering applications is an important issue that has received much consideration in the last decade.…”

Section: Morphology Of the Scaffolds After Crosslinkingmentioning

confidence: 99%

Cytocompatibility and Antibacterial Properties of Coaxial Electrospun Nanofibers Containing Ciprofloxacin and Indomethacin Drugs

et al. 2022

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A coaxial nanofibrous scaffold of poly (ε-caprolactone) and gelatin/cellulose acetate encapsulating anti-inflammatory and antibacterial drugs was co-electrospun for skin tissue regeneration. Indomethacin and ciprofloxacin as model drugs were added to the core and the shell solutions, respectively. The effect of the drugs’ presence and crosslinking on the scaffold properties was investigated. TEM images confirmed the core–shell structure of the scaffold. The fiber diameter and the pore size of the scaffold increased after crosslinking. The tensile properties of the scaffold improved after crosslinking. The crosslinked scaffold illustrated a higher rate of swelling, and a lower rate of degradation and drug release compared to the uncrosslinked one. Fitting the release data into the Peppas equation showed that Fickian diffusion was the dominant mechanism of drug release from the scaffolds. The results of biocompatibility evaluations showed no cytotoxicity and suitable adhesion and cell growth on the prepared core–shell structure. The antibacterial activity of the scaffolds was studied against one of the most common pathogens in skin wounds, where the existence of ciprofloxacin could prevent the growth of the Staphylococcus aureus bacteria around the scaffold. The obtained results suggested a new coaxial nanofibrous scaffold as a promising candidate for simultaneous tissue regeneration and controlled drug release.

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“…Since rapid biodegradability and weak mechanical properties are considered as the key drawbacks of Ge, it is normally used for tissue engineering combined with artificial polymers such as PCL to fulfill the mechanical properties requirement [23,24]. Yao et al [25] fabricated PCL/Ge nanofibrous scaffolds containing various polymer ratios for tissue engineering application.…”

Section: Introductionmentioning

confidence: 99%

Development of a Highly Proliferated Bilayer Coating on 316L Stainless Steel Implants

et al. 2020

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In this research, a bilayer coating has been applied on the surface of 316 L stainless steel (316LSS) to provide highly proliferated metallic implants for bone regeneration. The first layer was prepared using electrophoretic deposition of graphene oxide (GO), while the top layer was coated utilizing electrospinning of poly (ε-caprolactone) (PCL)/gelatin (Ge)/forsterite solutions. The morphology, porosity, wettability, biodegradability, bioactivity, cell attachment and cell viability of the prepared coatings were evaluated. The Field Emission Scanning Electron Microscopy (FESEM) results revealed the formation of uniform, continuous, and bead-free nanofibers. The Energy Dispersive X-ray (EDS) results confirmed well-distributed forsterite nanoparticles in the structure of the top coating. The porosity of the electrospun nanofibers was found to be above 70%. The water contact angle measurements indicated an improvement in the wettability of the coating by increasing the amount of nanoparticles. Furthermore, the electrospun nanofibers containing 1 and 3 wt.% of forsterite nanoparticles showed significant bioactivity after soaking in the simulated body fluid (SBF) solution for 21 days. In addition, to investigate the in vitro analysis, the MG-63 cells were cultured on the PCL/Ge/forsterite and GO-PCL/Ge/forsterite coatings. The results confirmed an excellent cell adhesion along with considerable cell growth and proliferation. It should be also noted that the existence of the forsterite nanoparticles and the GO layer substantially enhanced the cell proliferation of the coatings.

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Theoretical cross‐link density of the nanofibrous scaffolds

Cited by 8 publications

References 5 publications

Wound dressings: Current advances and future directions

Wound dressings: Current advances and future directions

Cytocompatibility and Antibacterial Properties of Coaxial Electrospun Nanofibers Containing Ciprofloxacin and Indomethacin Drugs

Development of a Highly Proliferated Bilayer Coating on 316L Stainless Steel Implants

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