Nanoformulated alpha-mangostin ameliorates Alzheimer's disease neuropathology by elevating LDLR expression and accelerating amyloid-beta clearance

α-Mangostin-encapsulated PLGA nanoparticles inhibit pancreatic carcinogenesis by targeting cancer stem cells in human, and transgenic (KrasG12D, and KrasG12D/tp53R270H) mice

“…α-Mangostin encapsulated Gold/polyethyleneimine/cyclodextrin (AuNPs/PEI/CD) nanoparticles inhibited prostate cancer PC-3 and DU-145 cell viability 46 . Furthermore, α-Mangostin encapsulated poly(ethylene glycol)-poly(l-lactide) (PEG-PLA) nanoparticles ameliorates Alzheimer’s disease neuropathology by elevating low density lipoprotein receptor (LDLR) expression in microglia and liver cells and accelerating amyloid-beta clearance 47 . A clinical trial with the 4-week-randomized, double-blind, placebo-controlled, split-face study in 10 acne patients demonstrated a significant improvement in acne vulgaris condition with cellulose-based α-mangostin nanoparticles 48 .…”

Neuronal mitochondria-targeted therapy for Alzheimer’s disease by systemic delivery of resveratrol using dual-modified novel biomimetic nanosystems

“…kg À1 of RSV. Next, after the last administration, the mice were trained and tested in the Morris water maze (MWM) as described previously (Yao et al, 2016). Briefly, the mice were trained three times a day for 5 days.…”

<p>Nanoparticle Drug Delivery Systems for α-Mangostin</p>

“…In vitro, the drug was rapidly released in the first 24 h (approximately 50%), followed by a slow, continuous release until 72 h and 100% release by 96 h. These results demonstrated a significant improvement of the pharmacokinetic and biodistribution profiles of nanoparticle compared to free α-mangostin. 76 Ethyl cellulose-methyl cellulose (EC-MC), a natural polymer from cellulose groups, was designed for αmangostin polymeric nanoparticle formulation as an antiacne therapy in a cosmeceutical form. The system was designed as a nanoreservoir system to achieve an extended release profile using a spray drying technique.…”

“…The nanomicelle uptake was mediated by endocytosis, a finding that indicated intracellular delivery of α-mangostin that could be associated with potential cytotoxicity (IC 50 of 8.9 ± 0.2 μg/mL). 82 Chitosan, PLGA Colloidal extraction solvent evaporation [75] PEG, PLA Emulsion/solvent evaporation techniques [76] PLGA Double emulsion solvent evaporation method [42] EC-MC Spray drying [77] Chitosan, alginate and genipin Ionotropic gelation method [78] β-cyclodextrin Inclusion complex technique [79] β-cyclodextrin-chitosan Inclusion complex [80] β-cyclodextrin Inclusion complex [81] Nanomicelles PVP Solvent evaporation method [82] MPEG and PLA Single-step self-assembly method [83] MPEG and PCL Self-assembly method [84] Liposome nanoparticles Transferrin Thin film hydration [85] Soya lecithin Phase separation coacervation method [86] Cholesterol, Tween 60 and ethanol Film hydration method [87] Solid lipid nanoparticles Lavender essential oil and cetyl palmitate Hot and high-pressure homogenisation techniques [88] PLGA and CD44 thioaptamer Nanoprecipitation combined with self-assembly [89] Nanofibres Thiolated chitosan Electrospinning [90] PVP Electrospinning [91] Metal nanoparticles Ag (silver) Chemical reaction by using silver nitrate (AgNO3) [92] Gold, PEI, cyclodextrin and tanshinone Chemical reaction using polyethyleneimine (PEI) [93] Emulsion nanoparticle Captex 200 P, Tween 80, carbopol 90 and silica Solid self-emulsification [94] Oleic acid, isopropyl myristate, Cremophor EL, Tween 80, carboxymethylcellulose sodium Self-microemulsion [31] In another study, α-mangostin nanomicelles with methoxypoly(ethylene glycol)-poly(lactide) (MPEG-PLA) were developed by a single-step self-assembly method for malignant glioma. In vitro and in vivo assays showed that the α-mangostin/MPEG-PLA nanoparticles inhibited cell growth and induced apoptosis-with cleaved caspase expression, DNA fragmentation, downregulation of antiapoptotic molecules and up-regulation of apoptotic molecules.…”