Nanoparticle formation of lycopene/β-cyclodextrin inclusion complex using supercritical antisolvent precipitation

Nerome, Hazuki; Machmudah, Siti; Diono, Wahyu; Fukuzato, Ryuichi; Higashiura, Takuma; Youn, Yong-Suk; Lee, Youn-Woo; Goto, Motonobu

doi:10.1016/j.supflu.2013.08.014

Cited by 87 publications

(37 citation statements)

References 30 publications

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“…6. This trend has also been observed in a previous work [29]. When the process was carried out at a lower pressure, the particles tended to be larger and plate-like.…”

Section: Effect Of Pressure and Temperaturesupporting

confidence: 88%

“…The solution-enhanced dispersion by supercritical fluids (SEDS) process is one of the modified SAS processes. In this process, the solution and SC-CO 2 are sprayed into a precipitator by a coaxial nozzle [11,[24][25][26][27][28] Water-soluble nanoparticles of the carotenoid/cyclodextrin complex were produced for synthesizing medicines by the SEDS process [29]. In this study, the organic solvent used was N,N-dimethylformamide (DMF), which is not approved anywhere in the world for use in food or supplement products.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Solvent on Nanoparticle Production of β‐Carotene by a Supercritical Antisolvent Process

et al. 2016

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Production of micro-to nano-sized particles of b-carotene was investigated by means of solution-enhanced dispersion by supercritical fluids (SEDS). b-Carotene was dissolved in dichloromethane (DCM), N,N-dimethylformamide (DMF), n-hexane, or ethyl acetate, and supercritical CO 2 served as an antisolvent. The effects of the organic solvents, operating pressure, and temperature were examined. The morphologies of the particles produced by the SEDS were observed by field emission-scanning electron microscopy and particle sizes were determined by image analysis. Irregularly shaped microparticles were produced in the system with DCM and DMF solution. Plate-like microparticles were generated by using n-hexane solution and irregular nanoparticles by ethyl acetate solution. The optimum operating conditions were found to be ethyl acetate as solvent in a defined pressure and temperature range.

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“…6. This trend has also been observed in a previous work [29]. When the process was carried out at a lower pressure, the particles tended to be larger and plate-like.…”

Section: Effect Of Pressure and Temperaturesupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Effect of Solvent on Nanoparticle Production of β‐Carotene by a Supercritical Antisolvent Process

et al. 2016

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“…Indeed, some authors attempted SAS polymer/drug coprecipitation; but, the obtained particles were generally irregular [37] or coalescing [38,39], with broad particle size distributions [40,41], low drug loadings [12,42] and, in most cases, the demonstration of the effective coprecipitation was at least questionable [43][44][45][46]. In general, the authors had difficulties in demonstrating that a coprecipitate was formed and that drug properties were improved.…”

Section: Introductionmentioning

confidence: 99%

Folic acid–PVP nanostructured composite microparticles by supercritical antisolvent precipitation

Prosapio

Marco

Scognamiglio

et al. 2015

Chemical Engineering Journal

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“…1 Among all the SAS-based particle fabrication techniques available, the SEDS process holds numerous advantages such as production of ultrafine particles with a narrow and uniform particle size distribution enhancing the dissolution rates of the APIs, high yields of polymer-based micro-and nano-sized composites, minimal agglomeration of particles, acceptable limits of residual solvents when operated at a reduced drying time, and ease of polymer coating over various particulate forms of APIs resulting in core-shell composites with sustained drug release ability, among others. [47][48][49][50] Moreover, this process is highly suitable for operating the water-soluble compounds by spraying the aqueous solutions along with the organic solvent separately through a coaxial three-compartment nozzle. 10,[51][52][53][54][55] However, there still exist some problems such as small processing capacity and easy blockage of the nozzle.…”

Section: Seds Processmentioning

confidence: 99%

Solution-enhanced dispersion by supercritical fluids: an ecofriendly nanonization approach for processing biomaterials and pharmaceutical compounds

Kankala¹,

Chen²,

Liu³

et al. 2018

IJN

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In recent years, the supercritical fluid (SCF) technology has attracted enormous interest from researchers over the traditional pharmaceutical manufacturing strategies due to the environmentally benign nature and economically promising character of SCFs. Among all the SCF-assisted processes for particle formation, the solution-enhanced dispersion by supercritical fluids (SEDS) process is perhaps one of the most efficient methods to fabricate the biomaterials and pharmaceutical compounds at an arbitrary gauge, ranging from micro- to nanoscale. The resultant miniature-sized particles from the SEDS process offer enhanced features concerning their physical attributes such as bioavailability enhancement due to their high surface area. First, we provide a brief description of SCFs and their behavior as an anti-solvent in SCF-assisted processing. Then, we aim to give a brief overview of the SEDS process as well as its modified prototypes, highlighting the pros and cons of the particular modification. We then emphasize the effects of various processing constraints such as temperature, pressure, SCF as well as organic solvents (if used) and their flow rates, and the concentration of drug/polymer, among others, on particle formation with respect to the particle size distribution, precipitation yield, and morphologic attributes. Next, we aim to systematically discuss the application of the SEDS technique in producing therapeutic nano-sized formulations by operating the drugs alone or in combination with the biodegradable polymers for the application focusing oral, pulmonary, and transdermal as well as implantable delivery with a set of examples. We finally summarize with perspectives.

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Nanoparticle formation of lycopene/β-cyclodextrin inclusion complex using supercritical antisolvent precipitation

Cited by 87 publications

References 30 publications

Effect of Solvent on Nanoparticle Production of β‐Carotene by a Supercritical Antisolvent Process

Effect of Solvent on Nanoparticle Production of β‐Carotene by a Supercritical Antisolvent Process

Folic acid–PVP nanostructured composite microparticles by supercritical antisolvent precipitation

Solution-enhanced dispersion by supercritical fluids: an ecofriendly nanonization approach for processing biomaterials and pharmaceutical compounds

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