The micelle structure of surfactant is easy to be destroyed in the flow process resulting in a decrease in its drag reduction (DR) efficiency; therefore, how to strengthen the stability of the micelle structure during the flow process and thus improve the drag reduction efficiency deserves intensive research. In this work, by comparing a variety of nanoparticles, hydrophobic silica nanoparticles were selected as the best additive to enhance the turbulence drag reduction efficiency of surfactant solution with spherical micelle structure. The experimental results also demonstrated that the hydrophobic silica nanoparticles had a reinforcing effect on anionic, cationic, nonionic, and zwitterionic surfactant solutions with the same concentration (dominated by spherical micelles), and the optimal nanoparticle addition concentration and maximum drag reduction rate were obtained. Meanwhile, the effect of silica nanoparticles on the turbulence drag reduction efficiency of surfactant solutions with different micelle structures was evaluated by inducing the surfactant micelle structure change. It was shown that the hydrophobic silica nanoparticles had a strengthening effect on the turbulence drag reduction performance of surfactant solutions with spherical micelle structure, while they had an inhibiting effect on the turbulence drag reduction performance of surfactant solutions with worm-like micelle structure. The change in solution viscoelasticity indicated that the decrease in viscoelasticity was the main reason for the decrease in drag reduction efficiency of surfactant solution with worm-like micelle structure when silica nanoparticles were added. A mechanism for the interaction of hydrophilic/hydrophobic silica nanoparticles with spherical micelles and wormlike micelle structures was finally discussed and proposed.