Nanoporous microspheres: from controllable synthesis to healthcare applications

Fan, Jun; Huang, Chao; Jiang, Lei; Wang, Shutao

doi:10.1039/c3tb00021d

Cited by 83 publications

(50 citation statements)

References 168 publications

(135 reference statements)

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“…In addition, the effects of drug chemistry and structure have been studied while maintaining the highly eccentric morphology (Supplementary Figure 4), evaluating the possibility of using this morphology for other drug-polymer combinations to treat various diseases. Due to higher interconnectivity, the highly eccentric drug clusters in polyethylene enabled the reduction of the drug percolation threshold from very high drug loading (40–60%) [23] to 6–8 wt% (Supplementary Figures 1 and 2, Figure 3a). The interconnected morphology also resulted in drug elution sustained for a longer duration (Figure 2d–f) and higher mechanical strength (Figure 2b–c) than those of drug eluting polyethylene with spherical drug clusters.…”

Section: Discussionmentioning

confidence: 99%

“…The antibiotic concentration in BC is limited by the minimum allowed mechanical properties, but results in low interconnectivity of drug clusters (Figure 1; [22]). In fact, for drug-eluting polymers with spherical drug clusters [23], it has been shown that 40–60 % (w/w) drug content is required to reach complete interconnectivity. Our goal was to develop load-bearing joint implant materials with efficient antibiotic release for at least 3 weeks and high mechanical strength and wear resistance within that of clinically used UHMWPE (Supplementary Discussion 1), to allow direct replacement of infected prosthetics with a new implant (Figure 1) without the complications and morbidity associated with a two-stage procedure.…”

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confidence: 99%

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A fully functional drug-eluting joint implant

et al. 2017

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Despite advances in orthopedic materials, the development of drug-eluting bone and joint implants that can sustain the delivery of the drug and maintain the necessary mechanical strength in order to withstand loading has remained elusive. Here, we demonstrate that modifying the eccentricity of drug clusters and the percolation threshold in ultrahigh molecular weight polyethylene (UHMWPE) results in maximized drug elution and in the retention of mechanical strength. The optimized UHMWPE eluted antibiotic at a higher concentration for longer than the clinical gold standard antibiotic-eluting bone cement while retaining the mechanical and wear properties of clinically used UHMWPE joint prostheses. Treatment of lapine knees infected with Staphylococcus aureus with the antibiotic-eluting UHMWPE led to complete bacterial eradication and to the absence of detectable systemic effects. We argue that the antibiotic-eluting UHMWPE joint implant is a promising candidate for clinical trials.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

A fully functional drug-eluting joint implant

et al. 2017

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“…Silica gel, zeolite, activated carbon, porous metal, and porous polymeric materials have been widely used as stationary phase of chromatographic separation, ion exchange resin, catalyst support, and aerospace research has been done to study various properties of monodisperse polystyrene microspheres with porous structures [5][6][7][8][9]. Different kinds of multistage methods, such as activated swelling [10,11], seeded emulsion polymerization [12], precipitation polymerization [13], template imprinting [14,15], and membrane techniques [16,17] have been developed to prepare the monodisperse porous polystyrene particles.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of monodisperse poly(styrene-co-divinylbenzene) microspheres with binary porous structures and application in high-performance liquid chromatography

Tian

Cong

et al. 2016

J Mater Sci

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Monodisperse poly(styrene-co-divinylbenzene) (PS-DVB) microspheres with binary porous structures were synthesized using a modified seeded polymerization method. The microspheres had small pores on the surface and big pores in the middle. Using the binary porous PS-DVB (BPPSD) microspheres as packing materials for high-performance liquid chromatography, several benzene analogs were effectively separated in a column as short as 75 mm due to the high surface areas of the stationary phase. Because of the p-p affinity interaction between BPPSD particles and analytes, the separation performance of the BPPSD column was better than commercialized C 18 column at the same conditions. Compared to column filled with non-porous PS-DVB particles, the back pressure of BPPSD column could be maintained at especially low level even at high flow rates due to the excellent permeability of the fillers. In addition, approximate baseline separation of C 60 and C 70 was also achieved in the 75 mm BPPSD column.

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“…For irregularly shaped defects, injectable scaffolds are more desirable for bone repair and regeneration [2][3][4]. Calcium phosphate (CaP) ceramics often used as bone graft substitutes (as opposed to biopolymer scaffolds [5][6][7][8][9][10][11][12]) as they show favorable biocompatibility, bioactivity, and bonelike chemical composition [13]; their unique chemical composition and structure afford them osteoinductivity, as evidenced by research on animal models [14].…”

Section: Introductionmentioning

confidence: 98%