Nanoscale topography of the basement membrane underlying the corneal epithelium of the rhesus macaque

Abrams, George A.; Goodman, Steven L.; Nealey, Paul F.; Franco, M.; Murphy, Christopher J.

doi:10.1007/s004419900074

Cited by 115 publications

(77 citation statements)

References 36 publications

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“…For example, basement membranes that provide the surrounding structure for most cells are composed of a dense meshwork of three-dimensional topography, featuring pores and fibers with dimensions ranging from tens to hundreds of nanometers. [294] Therefore it seems logical to us that NEs should have scale of at least some features in the same nanometer range.…”

Section: Basic Electrode Designmentioning

confidence: 99%

“…[257,326,340,341] Topographic stimuli appear to affect both neural and nonneuronal cell types, and different topographies exert varying effects on adherent cells. [294,328,[330][331][332][333][334][335] An approach toward topographic patterning that often proves effective is to mimic the REVIEW www.advmat.de physiological structures that normally interact with the cell type of interest.…”

Section: Topographymentioning

confidence: 99%

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Nanomaterials for Neural Interfaces

et al. 2009

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This review focuses on the application of nanomaterials for neural interfacing. The junction between nanotechnology and neural tissues can be particularly worthy of scientific attention for several reasons: (i) Neural cells are electroactive, and the electronic properties of nanostructures can be tailored to match the charge transport requirements of electrical cellular interfacing. (ii) The unique mechanical and chemical properties of nanomaterials are critical for integration with neural tissue as long‐term implants. (iii) Solutions to many critical problems in neural biology/medicine are limited by the availability of specialized materials. (iv) Neuronal stimulation is needed for a variety of common and severe health problems. This confluence of need, accumulated expertise, and potential impact on the well‐being of people suggests the potential of nanomaterials to revolutionize the field of neural interfacing. In this review, we begin with foundational topics, such as the current status of neural electrode (NE) technology, the key challenges facing the practical utilization of NEs, and the potential advantages of nanostructures as components of chronic implants. After that the detailed account of toxicology and biocompatibility of nanomaterials in respect to neural tissues is given. Next, we cover a variety of specific applications of nanoengineered devices, including drug delivery, imaging, topographic patterning, electrode design, nanoscale transistors for high‐resolution neural interfacing, and photoactivated interfaces. We also critically evaluate the specific properties of particular nanomaterials—including nanoparticles, nanowires, and carbon nanotubes—that can be taken advantage of in neuroprosthetic devices. The most promising future areas of research and practical device engineering are discussed as a conclusion to the review.

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Section: Basic Electrode Designmentioning

confidence: 99%

Section: Topographymentioning

confidence: 99%

Nanomaterials for Neural Interfaces

et al. 2009

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“…[9] The control of the chemical structure of artificial materials in the bulk, however, is only the preliminary step for controlling the evolution of cellular structures on their surface, since cell-substrate signalling is regulated by topographical and chemical patterns organized on scales ranging from the nanometer to the micrometer, [1,10] as observed for the extracellular matrix where cells are aligned and guided via micro and nanotopographies formed by the hierarchical organization of collagen molecules. [11] Cells interact with topographical cues through a phenomenon known as contact guidance, [12,13] regulating cell shape and motility and playing an essential role for several homeostatic processes, such as wound healing and tissue repair. [14] Contact guidance is particularly important for the organization of neural cell networks in the developing brain: these networks are formed during development as maturing neurons extend processes to reach synaptic targets.…”

Section: Introductionmentioning

confidence: 99%

Direct Microfabrication of Topographical and Chemical Cues for the Guided Growth of Neural Cell Networks on Polyamidoamine Hydrogels

Reis

Fenili

Gianfelice

et al. 2010

Macromolecular Bioscience

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Cell patterning is an important tool for organizing cells in surfaces and to reproduce in a simple way the tissue hierarchy and complexity of pluri-cellular life. The control of cell growth, proliferation and differentiation on solid surfaces is consequently important for prosthetics, biosensors, cell-based arrays, stem cell therapy and cell-based drug discovery concepts. We present a new electron beam lithography method for the direct and simultaneous fabrication of sub-micron topographical and chemical patterns, on a biocompatible and biodegradable PAA hydrogel. The localized e-beam modification of a hydrogel surface makes the pattern able to adsorb proteins in contrast with the anti-fouling surface. By also exploiting the selective attachment, growth and differentiation of PC12 cells, we fabricated a neural network of single cells connected by neuritis extending along microchannels. E-beam microlithography on PAA hydrogels opens up the opportunity of producing multifunctional microdevices incorporating complex topographies, allowing precise control of the growth and organization of individual cells.

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“…Among these properties, the topographic feature has been considered a critical factor for cell attachment and growth. The effects of surface features (such as pores, pits and random surface roughness) on cell behavior have been demonstrated to be important for anchorage-dependent cells to adhere to the surface and consequently spread on the surface [21,25,26]. Therefore, surface modification created by facile treatment appears to be a promising approach.…”

Section: Cell Adhesion and Proliferationmentioning

confidence: 98%

“…Many articles have reported the interactions between surfaces and cells, because cell-compatible materials are thought to be very important in many biomedical applications, such as the development of tissue engineering [21][22][23][24][25]. In the design of microcarriers for cell attachment and growth, surface properties (e.g., topographic feature, roughness, rigidity and so on) are important considerations.…”

Section: Cell Adhesion and Proliferationmentioning

confidence: 99%